Results 301 to 310 of about 1,084,742 (347)

Distribution and Expression of Transforming Growth Factor-β and Platelet-derived Growth Factor in the Normal and Glaucomatous Monkey Optic Nerve Heads

Japanese Journal of Ophthalmology, 2001
Remodeling of the extracellular matrix occurs in the lamina cribrosa in progressed glaucomatous optic nerve damage including disc cupping. We examined immunohistochemical changes in the transforming growth factor (TGF)-beta and platelet-derived growth factor (PDGF) in the optic nerve head in an experimentally induced glaucoma model.We used 3 cynomolgus
T, Fukuchi, J, Ueda, T, Hanyu, H, Abe, S, Sawaguchi   +4 more
openaire   +2 more sources

Transforming growth factor-β2 regulates C3 secretion in monocytes through a protein kinase C-dependent pathway

Molecular Immunology, 1998
Previously, we reported that TGF-beta2 regulates the C3 gene expression in a dose- and time-dependent manner in monocytes. To extend these studies, we examined the role of PKC in the TGF-beta2-mediated induction of C3 expression by the human monocyte cell line, U937.
S M, Drouin, S C, Kiley, J A, Carlino, S R, Barnum   +3 more
openaire   +2 more sources

Transforming growth factor β signaling pathway: A promising therapeutic target for cancer

Journal of Cellular Physiology, 2019
Transforming growth factor β (TGF‐β) is part of the transforming growth factor β superfamily which is involved in many physiological processes and closely related to the carcinogenesis.
Yuhong Chen, C. Di, Xuetian Zhang, Jing Wang, F. Wang, Junfang Yan, Caipeng Xu, Jinhua Zhang, Qianjing Zhang, Hongyan Li, Hongying Yang, Hong Zhang   +11 more
semanticscholar   +1 more source

Physiological Responses to a Natural Antioxidant Flavonoid Mixture, Silymarin, in BALB/c Mice: I Induction of Transforming Growth Factor β1 and c-myc in Liver with Marginal Effects on Other Genes

Planta Medica, 2002
Silymarin, a mixture of flavonolignans isolated from Silybum marianum, is known for its hepatoprotective properties. We investigated the expression of cytokines in mouse liver following treatment with 0, 10, 50, and 250 mg/kg of silymarin once daily for 5 days.
Quanren, He, Marcin F, Osuchowski, Victor J, Johnson, Raghubir P, Sharma   +3 more
openaire   +2 more sources

Transforming growth factor-β in myocardial disease

Nature Reviews Cardiology, 2022
N. Frangogiannis
semanticscholar   +1 more source

Transforming growth factor‐β signaling: Tumorigenesis and targeting for cancer therapy

Journal of Cellular Physiology, 2018
Transforming growth factor (TGF)‐β is a multitasking cytokine such that its aberrant expression is related to cancer progression and metastasis. TGF‐β is produced by a variety of cells within the tumor microenvironment (TME), and it is responsible for ...
A. Ahmadi, M. Najafi, Bagher Farhood, K. Mortezaee   +3 more
semanticscholar   +1 more source

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

Nature, 1985
R. Derynck, J. A. Jarrett, E. Chen, D. Eaton, J. R. Bell, R. Assoian, A. Roberts, M. Sporn, D. Goeddel   +8 more
semanticscholar   +1 more source

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

Nature Immunology, 2007
Eva Acosta-Rodriguez, G. Napolitani, A. Lanzavecchia, F. Sallusto   +3 more
semanticscholar   +1 more source

Transforming Growth Factor β in Tissue Fibrosis

, 1994
W. A. Border, N. Noble
semanticscholar   +1 more source

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

Nature Immunology, 2008
M. Veldhoen, C. Uyttenhove, J. Snick, H. Helmby, A. Westendorf, J. Buer, Bruno Martin, C. Wilhelm, B. Stockinger   +8 more
semanticscholar   +1 more source