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Transforming growth factor beta.
Advances in cancer research, 1989Transforming growth factor beta (TGF-beta) stimulates fibrosis. We studied its possible role as a bioactive substance for inducing localized chorioretinal wound healing along the edge of a retinal tear. The TGF-beta was applied to induced retinal tears that were examined histopathologically.
A B, Roberts, M B, Sporn
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Liver international (Print), 2019
We assessed the activity of galunisertib, a small molecule inhibitor of the transforming growth factor beta (TGF‐β1) receptor I, in second‐line patients with hepatocellular carcinoma (HCC) in two cohorts of baseline serum alpha fetoprotein (AFP).
S. Faivre +11 more
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We assessed the activity of galunisertib, a small molecule inhibitor of the transforming growth factor beta (TGF‐β1) receptor I, in second‐line patients with hepatocellular carcinoma (HCC) in two cohorts of baseline serum alpha fetoprotein (AFP).
S. Faivre +11 more
semanticscholar +1 more source
Transforming growth factor‐beta 3.
Cell Biology International, 1995ABSTRACTTransforming Growth Factor‐Beta (TGF‐β) is the general name for a family of naturally‐occurring polypeptides which have multiple regulatory effects on cell proliferation and differentiation. Over the last decade it has become apparent that TGF‐βs can be produced by most cell types and exert a wide range of effects in a context‐dependent ...
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British Medical Bulletin, 1989
Since its discovery as a factor able to induce phenotypic transformation with transforming growth factor alpha, transforming growth factor beta (TGF beta) has been found to have unexpectedly widespread and frequently, seemingly paradoxical effects on a variety of cell types.
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Since its discovery as a factor able to induce phenotypic transformation with transforming growth factor alpha, transforming growth factor beta (TGF beta) has been found to have unexpectedly widespread and frequently, seemingly paradoxical effects on a variety of cell types.
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Transforming growth factor beta in Alzheimer's disease
Clinical Diagnostic Laboratory Immunology, 1994Alzheimer's disease (AD) has been hypothesized to be an inflammatory condition. We hypothesized that anti-inflammatory cytokines, such as transforming growth factor beta (TGF-beta), counteract the inflammatory process. In the present study, we found that TGF-beta levels were elevated in both cerebrospinal fluid and serum samples obtained from AD ...
C C, Chao +5 more
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Transforming Growth Factor Beta in Pancreatic Cancer
Current Pharmaceutical Biotechnology, 2011Pancreatic cancer has high incidence and mortality rates, and effective treatment remains a clinical challenge. As deregulation of the cytokine transforming growth factor beta (TGF-β) contributes to the progression of pancreatic carcinoma, the TGF-β pathway has been targeted using various strategies, including small molecule inhibitors of TGF-βRI, TGF ...
Andreas, Hilbig, Helmut, Oettle
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What is transforming growth factor-beta (TGF-β)?
British Journal of Plastic Surgery, 2004The TGF-beta superfamily of proteins produces a wide range of frequently opposing effects in different cells and tissues in the body. However, its activation and mode of action are only partially understood because of its complexity in structure and functions and the variability in its downstream targets.
Chin, David +3 more
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Transforming Growth Factor Beta in Fracture Repair
Clinical Orthopaedics and Related Research, 1998Transforming growth factor betas are a group of polypeptide growth factors that have a wide range of activities in the musculoskeletal and immunological systems. They are thought to play an important role in the development, induction, and repair of bone.
M P, Bostrom, P, Asnis
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Transforming growth factor beta: Relevance to radiotherapy
Clinical Oncology, 1995supporting evidence, both from animal work and from clinical findings, to implicate TGFfi in the pathogenesis of radiofibrosis. Animal studies have shown an association between TGFfi levels and radiation fibrosis. In rat liver, the percentage of hepatocytes staining strongly positive for TGFfi after radiation correlates with the extent of subsequent ...
C C, Parker, J R, Yarnold
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Transforming growth factor-beta.
Cancer surveys, 1992This chapter has described some of the most salient features of the biology of the TGF-beta s. The TGF-beta s are of great interest as growth inhibitors, regulators of cell phenotype and regulators of cell adhesion. The various TGF-beta isoforms are highly conserved and display a complex pattern of interactions with multiple membrane receptor ...
J, Massagué +5 more
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