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Transforming growth factor betas in mammalian embryogenesis
Progress in Growth Factor Research, 1990Type beta transforming growth factors (TGF beta s) are members of a large superfamily of related proteins, each of which plays a pivotal role in embryonic processes. The TGF beta s per se are at least five in number, though only three isoforms have been identified in mammals.
Akhurst, Rosemary J. +4 more
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Transforming growth factor beta and the endometrium
Reviews of Reproduction, 1998During the oestrous or menstrual cycle and throughout much of pregnancy, the uterine endometrium undergoes rapid, as well as progressive, morphological and functional modification. During the preimplantation stage of pregnancy, the endometrium provides an environment that sustains embryonic development, and then participates in the nidation process ...
J D, Godkin, J J, Doré
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Urology, 2008
The mouse renal cell carcinoma line, Renca, is insensitive to transforming growth factor-beta (TGF-beta) in vitro. The present study was conducted to determine whether removal of TGF-beta from these tumor cells would inhibit tumor progression in vivo.TGF-beta elimination was accomplished either by administration of neutralizing TGF-beta antibody into ...
Kent, Perry +11 more
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The mouse renal cell carcinoma line, Renca, is insensitive to transforming growth factor-beta (TGF-beta) in vitro. The present study was conducted to determine whether removal of TGF-beta from these tumor cells would inhibit tumor progression in vivo.TGF-beta elimination was accomplished either by administration of neutralizing TGF-beta antibody into ...
Kent, Perry +11 more
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The Journal of Immunology, 1991
Abstract Participation of human polymorphonuclear neutrophils in the inflammatory response is mediated, in part, by soluble factors such as chemotactic peptides and cytokines. Although the cytokine, transforming growth factor beta (TGF-beta), has been shown to recruit monocytes and promote the inflammatory process, its effects on ...
M E, Brandes +3 more
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Abstract Participation of human polymorphonuclear neutrophils in the inflammatory response is mediated, in part, by soluble factors such as chemotactic peptides and cytokines. Although the cytokine, transforming growth factor beta (TGF-beta), has been shown to recruit monocytes and promote the inflammatory process, its effects on ...
M E, Brandes +3 more
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Transforming growth factor-beta (TGF-beta).
The international journal of biochemistry & cell biology, 1998The TGF-beta family of cytokines are ubiquitous, multifunctional and essential to survival. They play important roles in growth and development, inflammation and repair and host immunity. The mammalian TGF-beta isoforms (TGF-beta 1, beta 2 and beta 3) are secreted as latent precursors and have multiple cell surface receptors of which at least two ...
D A, Clark, R, Coker
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Transforming Growth Factor Beta and Prostate Cancer
2005The TGF-beta superfamily is the most versatile considering the ability of its members to regulate proliferation, growth arrest, differentiation, and apoptosis of prostatic stromal and epithelial cells as well as the formation of osteoblastic metastases.
Brian, Zhu, Natasha, Kyprianou
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Transforming Growth Factor-β Signal Transduction
Circulation Research, 1996The TGF-β superfamily of cytokines comprises an array of more than two dozen secreted peptides that have been implicated as multifunctional regulators of cell growth, differentiation, and function.1 2 Members of this family are pivotal for normal development in a variety of species, providing diffusible signals that influence pattern formation, body ...
T, Brand, M D, Schneider
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Transforming growth factor β and cancer
Cancer Treatment Reviews, 1995Udgivelsesdato: 1995 ...
Nørgaard, P +3 more
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Transforming Growth Factor-Beta Protocols
2000In Vitro Assays for Measuring TGFb Growth Stimulation and Inhibition. Measurements of Active TGFb Generated by Cultured Cells. Methods For iodination of TGFb, TGFb Receptor Crosslinking and Immunoprecipitation of TGFb-Receptor Complexes. Detection of TGFb in Body Fluids and Tissues. Analysis of TGFb-Mediated Synthesis of Extracellular Matrix Components.
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Growth regulation by transforming growth factor-β
1993The name transforming growth factor-s (TGF-s) has come to represent a family of highly homologous polypeptides with a wide range of biological activities. The first member of this gene family was identified nearly a decade ago as one of two essential factors, called TGF-α and TGF-s present in the conditioned medium of a murine sarcoma virus-transformed
B A, Arrick, R, Derynck
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