Results 91 to 100 of about 360,625 (378)

3D bioprinted CRC model brings to light the replication necessity of an oncolytic vaccinia virus encoding FCU1 gene to exert an efficient anti-tumoral activity

Frontiers in Oncology
The oncolytic virus represents a promising therapeutic strategy involving the targeted replication of viruses to eliminate cancer cells, while preserving healthy ones. Despite ongoing clinical trials, this approach encounters significant challenges. This
Christophe A. Marquette, Emma Petiot, Anita Spindler, Caroline Ebel, Mael Nzepa, Baptiste Moreau, Philippe Erbs, Jean-Marc Balloul, Eric Quemeneur, Cécile Zaupa   +9 more
doaj   +1 more source

Sec6 mutations and the Drosophila exocyst complex [PDF]

, 2005
To allow a detailed analysis of exocyst function in multicellular organisms, we have generated sec6 mutants in Drosophila. We have used these mutations to compare the phenotypes of sec6 and sec5 in the ovary and nervous system, and we find them to be ...
Denef, Natalie, Higashi, Misao E. L., Murthy, Mala, Ranjan, Ravi, Schupbach, Trudi, Schwarz, Thomas L.   +5 more
core   +2 more sources

Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons

Molecular Brain, 2014
Adeno-associated virus (AAV) vectors can deliver transgenes to diverse cell types and are therefore useful for basic research and gene therapy. Although AAV has many advantages over other viral vectors, its relatively small packaging capacity limits its ...
Jun-Hyeok Choi, Nam-Kyung Yu, Gi-Chul Baek, Joseph Bakes, Daekwan Seo, Hye Jin Nam, S. H. Baek, C. Lim, Yong-Seok Lee, B. Kaang   +9 more
semanticscholar   +1 more source

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology [PDF]

, 2016
Peer ...
Drever, Benjamin D., Koss, David J., Platt, Bettina, Plucinska, Kaja, Riedel, Gernot, Robinson, Lianne, Stoppelkamp, Sandra, Veselcic, Peter   +7 more
core   +3 more sources

PHR‐Mediated Pi Starvation Response Mobile Messenger RNAs Represent Noncoding Transcripts in Recipient Tissues

Advanced Science, EarlyView.
Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong, Shuman Wang, Chao Liu, Lulu Qiao, Kai Liu, Qiongli Jin, Xiaorong Mo, Xingxing Shen, Keke Yi, Zhiye Wang   +9 more
wiley   +1 more source

Neuronal Transgene Expression in Dominant-Negative SNARE Mice

Journal of Neuroscience, 2014
Experimental advances in the study of neuroglia signaling have been greatly accelerated by the generation of transgenic mouse models. In particular, an elegant manipulation that interferes with astrocyte vesicular release of gliotransmitters via ...
T. Fujita, Michael J. Chen, Baoman Li, N. A. Smith, Weiguo Peng, Wei Sun, Michael J Toner, Benjamin T. Kress, Lin-Hui Wang, A. Benraiss, T. Takano, Su Wang, M. Nedergaard   +12 more
semanticscholar   +1 more source

BioCNTs Mediated Delivery of Systemically Mobile Small RNAs via Leaf Spray to Control Both Tomato DNA and RNA Viruses

Advanced Science, EarlyView.
A carbon nanotube‐based biopesticide system (BioCNTs) enables efficient delivery and systemic movement of RNAi molecules to control major tomato viruses. By integrating shRNA and tRNA‐like structures (TLS) with BioCNTs, this green and scalable approach achieves long‐term silencing and high antiviral efficacy through simple foliar spraying.
Xuedong Liu, Xiaofei Liang, Zipeng Cai, Zheng Liu, Xuefeng Wang, Changyong Zhou, Mengji Cao, Sijia Liu   +7 more
wiley   +1 more source

Patient-derived tumoroids and proteomic signatures: tools for early drug discovery

Frontiers in Immunology
Onco-virotherapy is an emergent treatment for cancer based on viral vectors. The therapeutic activity is based on two different mechanisms including tumor-specific oncolysis and immunostimulatory properties.
Hélène Lê, Hélène Lê, Jules Deforges, Pasquale Cutolo, Anissa Lamarque, Guoqiang Hua, Véronique Lindner, Véronique Lindner, Shreyansh Jain, Jean-Marc Balloul, Nadia Benkirane-Jessel, Eric Quéméneur   +11 more
doaj   +1 more source

Genome editing in potato via CRISPR-Cas9 ribonucleoprotein delivery [PDF]

, 2018
Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein-9 (CRISPR-Cas9) can be used as an efficient tool for genome editing in potato (Solanum tuberosum).
Andersson, Andersson, Cho, Clasen, Eriksson, Gorbunova, Hartung, Jinek, Jones, Kim, Kuipers, Kuipers, Larkin, Liang, Muthoni, Nelson, Sawai, Shepard, Svitashev, Visser, Woo, Xu, Zhang   +22 more
core   +1 more source