Results 101 to 110 of about 361,542 (380)

Environmental risk assessment of genetically modified plants - concepts and controversies [PDF]

, 2011
Background and purpose: In Europe, the EU Directive 2001/18/EC lays out the main provisions of environmental risk assessment (ERA) of genetically modified (GM) organisms that are interpreted very differently by different stakeholders. The purpose of this
A Hilbeck, A Hilbeck, A Hilbeck, A Hilbeck, A Hilbeck, A Hilbeck, A Lang, A Raps, A Raybould, A Raybould, AL Cerdeira, ANE Birch, B Lutz, C Hawes, C Zwahlen, C Zwahlen, CB Blackwood, CBD, Council of the European Union, D Saxena, DA Andow, DA Andow, DA Andow, DJ Baird, EC, EC, EFSA, EJ Rosi-Marshall, Environmental Protection Agency (EPA), EP Millstone, EPA Environmental Protection Agency OPPTS 7501P, EurActive, FAO/WHO, J Romeis, J Romeis, J Romeis, J Scheirs, JD Harwood, JD Harwood, KC Nelson, KC Nelson, KR Hayes, KR Hayes, LB Obrist, M Dolezel, M Douville, M Garcia-Alonso, M Mendelsohn, MC Arregui, MR Berenbaum, National Research Council (NRC), OECD, OECD (Organisation for Economic Cooperation and Development), PM Chapman, Royal Society of Canada, T Bøhn, VE Forbes, W Freese   +57 more
core   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Neuronal Transgene Expression in Dominant-Negative SNARE Mice

Journal of Neuroscience, 2014
Experimental advances in the study of neuroglia signaling have been greatly accelerated by the generation of transgenic mouse models. In particular, an elegant manipulation that interferes with astrocyte vesicular release of gliotransmitters via ...
T. Fujita, Michael J. Chen, Baoman Li, N. A. Smith, Weiguo Peng, Wei Sun, Michael J Toner, Benjamin T. Kress, Lin-Hui Wang, A. Benraiss, T. Takano, Su Wang, M. Nedergaard   +12 more
semanticscholar   +1 more source

Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones [PDF]

, 2011
Peer reviewedPublisher ...
Davidson, Scott, Lear, Marissa, MacKenzie, Alasdair, Ross, Ruth Alexandra, Shanley, Lynne   +4 more
core   +4 more sources

Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins

Advanced Science, EarlyView.
As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhäuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert J. Kittel, Alexander Gottschalk, Adam Claridge‐Chang, Shiqiang Gao   +14 more
wiley   +1 more source

Sec6 mutations and the Drosophila exocyst complex [PDF]

, 2005
To allow a detailed analysis of exocyst function in multicellular organisms, we have generated sec6 mutants in Drosophila. We have used these mutations to compare the phenotypes of sec6 and sec5 in the ovary and nervous system, and we find them to be ...
Denef, Natalie, Higashi, Misao E. L., Murthy, Mala, Ranjan, Ravi, Schupbach, Trudi, Schwarz, Thomas L.   +5 more
core   +2 more sources

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

Patient-derived tumoroids and proteomic signatures: tools for early drug discovery

Frontiers in Immunology
Onco-virotherapy is an emergent treatment for cancer based on viral vectors. The therapeutic activity is based on two different mechanisms including tumor-specific oncolysis and immunostimulatory properties.
Hélène Lê, Hélène Lê, Jules Deforges, Pasquale Cutolo, Anissa Lamarque, Guoqiang Hua, Véronique Lindner, Véronique Lindner, Shreyansh Jain, Jean-Marc Balloul, Nadia Benkirane-Jessel, Eric Quéméneur   +11 more
doaj   +1 more source

Fitness Impact and Stability of a Transgene Conferring Resistance to Dengue-2 Virus following Introgression into a Genetically Diverse Aedes aegypti Strain

PLoS Neglected Tropical Diseases, 2014
In 2006, we reported a mariner (Mos1)-transformed Aedes aegypti line, Carb77, which was highly resistant to dengue-2 virus (DENV2). Carb77 mosquitoes expressed a DENV2-specific inverted-repeat (IR) RNA in midgut epithelial cells after ingesting an ...
A. Franz, I. Sánchez-Vargas, Robyn R. Raban, W. Black, A. James, K. Olson   +5 more
semanticscholar   +1 more source

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

Advanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao, Matthew F. Yee, Chaitanya N. Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus Ruscetti, Shun‐Qing Liang, Wen Xue   +9 more
wiley   +1 more source