Results 131 to 140 of about 360,625 (378)

Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons.

Molecular Therapy, 2009
Therapeutic gene delivery to the whole spinal cord is a major challenge for the treatment of motor neuron (MN) diseases. Systemic administration of viral gene vectors would provide an optimal means for the long-term delivery of therapeutic molecules from
S. Duqué, B. Joussemet, C. Rivière, Thibaut Marais, L. Dubreil, A. Douar, J. Fyfe, P. Moullier, M. Colle, M. Barkats   +9 more
semanticscholar   +1 more source

A Set of Novel Venom Proteins Enables Parasitoid Wasps to Exploit Older Hosts and Coexist with Competitors

Advanced Science, EarlyView.
This study elucidates a molecular mechanism enabling species coexistence between parasitoid wasps, showing how Asobara japonica uses a set of novel venom proteins to delay host development and exploit older hosts, thereby achieving temporal niche partitioning with Leptopilina drosophilae. Abstract Interspecific competition can drive species coexistence
Junwei Zhang, Zhi Dong, Yifeng Sheng, Jieyu Shan, Ting Feng, Wenqi Shi, Zixuan Xu, Zeying Wang, Qichao Zhang, Ying Wang, Jianhua Huang, Jiani Chen   +11 more
wiley   +1 more source

The promoter from SlREO, a highly-expressed, root-specific Solanum lycopersicum gene, directs expression to cortex of mature roots [PDF]

, 2008
Root-specific promoters are valuable tools for targeting transgene expression, but many of those already described have limitations to their general applicability.
Abe, Andrew J. Thompson, Bassett, Benfey, Bird, Bradford, Bucher, Bucher, Butler, Cardon, Carole Wright, Chan, Chen, Diatchenko, Elmayan, Fester, Garoosi, Giritch, Giritch, Gittins, Grichko, Gubler, Hagen, Hans, Hausinger, Hertig, Higo, Hudson, Ian B. Taylor, Itzhaki, Jefferson, John Andrews, Karimi, Keller, Kenneth Manning, Klinedinst, Koyama, Krasnyanski, K�ck, Liang, Liedl, L�on-Kloosterziel, Marin, Matsuda, Matthew O. Jones, Mudge, Mudge, Okubara, Phillips, Prescott, Prescott, Radi, Ro, Saslowsky, Sobeih, Subramanian, Suzuki, Tang, Thompson, Tirajoh, Vaughan, von Schweinichen, White, Xiao, Xu, Yamamoto, Yoshimoto, Zhang, Zhang   +68 more
core   +1 more source

Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin

Journal of Experimental Medicine, 2005
The cytokine thymic stromal lymphopoietin (TSLP) has recently been implicated in the pathogenesis of atopic dermatitis (AD) and other allergic diseases in humans.
Jane Yoo, M. Omori, Dora Gyarmati, Baohua Zhou, Theingi Aye, A. Brewer, M. Comeau, D. Campbell, S. Ziegler   +8 more
semanticscholar   +1 more source

NUSAP1 Recruits DAXX to Suppress HIF‐Driven Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
A double‐negative feedback loop is identified in TNBC where NUSAP1 bridges HIF and DAXX via its microtubule‐associated domain (MAD) to recruit SETDB1, repressing HIF transcriptional activity by depositing the H3K9me3 repressive mark on HIF target genes, while HIF itself suppresses NUSAP1.
Yating Du, Jingjing Wang, Min Wang, Yao Zhang, Miaomiao Zheng, Huiyan Li, Xuemeng Wang, Huanran Sun, Kexin Tang, Changliang Shan, Qiang Zhao, Xiaoqian Meng, Yijie Wang, Jun Zhou, Yan Chen   +14 more
wiley   +1 more source

Global Screening of Antiviral Genes that Suppress Baculovirus Transgene Expression in Mammalian Cells

Molecular Therapy: Methods & Clinical Development, 2017
Although baculovirus has been used as a safe and convenient gene delivery vector in mammalian cells, baculovirus-mediated transgene expression is less effective in various mammalian cell lines.
Chia-Hung Wang, Nenavath Gopal Naik, Lin-Li Liao, Sung-Chan Wei, Yu-Chan Chao   +4 more
doaj   +1 more source

NIR‐Triggered Upconversion‐Perovskite Heterostructures for Non‐Genetic, Implant‐Free Optoelectronic Neuromodulation

Advanced Science, EarlyView.
The Single‐Nanostructured Optoelectronic Vehicle for neuromodulation Activation (SNOVA) establishes a paradigm for non‐genetic, implant‐free neuromodulation. By integrating NIR‐excitable UCNPs with broadband‐absorbing perovskite QDs, SNOVA efficiently converts deeply penetrating light into localized electric fields that modulate neuronal ion dynamics ...
Luyue Jiang, Chenguang Ma, Yiping Zhao, Jiazhi Li, Gen Li, Shuang Jin, Haoyang Su, Ye Tian, Yingkang Yang, Yunfu Luo, Lei Huang, Peijie Chen, Yiming Gao, Yi Wei, Yike Xiang, Lunming Qin, Kaihuan Zhang, Yifei Ye, Pengyi Tang, Liuyang Sun   +19 more
wiley   +1 more source

Effects of overexpression of jasmonic acid biosynthesis genes on nicotine accumulation in tobacco

Plant Direct, 2018
Nicotine is naturally synthesized in tobacco roots and accumulates in leaves as a defense compound against herbivory attack. Nicotine biosynthesis pathway has been extensively studied with major genes and enzymes being isolated and functionally ...
Hongxia Chen, Bingwu Wang, Sisi Geng, Consuelo Arellano, Sixue Chen, Rongda Qu   +5 more
doaj   +1 more source

Assembly of Two Transgenes in an Artificial Chromatin Domain Gives Highly Coordinated Expression in Tobacco [PDF]

, 2002
Ľudmila Mlynárová, Annelies E. H. M. Loonen, Elzbieta Mietkiewska, Ritsert C. Jansen, Jan‐Peter Nap   +4 more
openalex   +1 more source

Green Fluorescent Protein in the sea urchin: new experimental approaches to transcriptional regulatory analysis in embryos and larvae [PDF]

, 1997
The use of Green Fluorescent Protein (GFP) as a reporter for expression transgenes opens the way to several new experimental strategies for the study of gene regulation in sea urchin development.
Arnone, Maria I., Bogarad, Leonard D., Cameron, R. Andrew, Collazo, Andres, Davidson, Eric H., Gregorians, Armenia, Kirchhamer, Carmen V., Rast, Jonathan P.   +7 more
core