Results 151 to 160 of about 227,142 (341)
Induction of Interleukin 2‐Responsiveness in Thymocytes of the Transgenic Mice Carrying lck‐Transgene [PDF]
, 1993 Yoichi Moroi +5 more
openalex +1 more source
Advanced Science, EarlyView.FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song +17 more
wiley +1 more source
Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina [PDF]
, 1999 Jean Bennett +15 more
openalex +1 more source
Advanced Science, EarlyView.Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil +12 more
wiley +1 more source
The risk of crop transgene spread [PDF]
, 1996 Thomas Raundahl Mikkelsen +2 more
openalex +1 more source
m6A Methylation‐Induced Autophagy Impairment by TFEB Regulation in SOD1‐G93A ALS Cell Model
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT We investigate the role of m6A RNA methylation in regulating transcription factor EB (TFEB) and its contribution to mitochondrial autophagy (mitophagy) dysfunction in amyotrophic lateral sclerosis (ALS). ALS cell models were used to analyse mitophagy markers and TFEB expression under METTL3 and TFEB modulation, using RT‐qPCR, Western blot ...
Di An +7 more
wiley +1 more source
Systemic gene therapy: biodistribution and long-term expression of a transgene in mice. [PDF]
, 1995 Alain R. Thierry +5 more
openalex +1 more source
Technological breakthroughs in generating transgene-free and genetically stable CRISPR-edited plants
aBIOTECH, 2019 Yubing He, Yunde Zhao
semanticscholar +1 more source
Animal Models and Experimental Medicine, EarlyView.In this study, we established a mouse model in which CAG repeats do not undergo microsatellite instability (MSI) across generations. A humanized ATXN2 cDNA with four CAA interruptions within 73 CAG expansions was inserted into the Rosa26 locus of C57BL/6J mice. At the same time, a 23 CAG control mouse model was also generated.
Yao Zhang +9 more
wiley +1 more source
An HLA-DR1 Transgene Confers Susceptibility to Collagen-induced Arthritis Elicited with Human Type II Collagen [PDF]
, 1997 Edward F. Rosloniec +9 more
openalex +1 more source