T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
A transgene carrying an A2G missense mutation in the SMN gene modulates phenotypic severity in mice with severe (type I) spinal muscular atrophy [PDF]
, 2003 Umrao R. Monani +11 more
openalex +1 more source
Side Effects of Single-Transgene or Pyramided Genetically Modified Maize on the Generalist Endoparasitoid Palmistichus elaeisis (Hymenoptera: Eulophidae) [PDF]
, 2023 Michael Willian Rocha de Souza +7 more
openalex +1 more source
Linear signaling in the Toll-Dorsal pathway of Drosophila: activated Pelle kinase specifies all threshold outputs of gene expression while the bHLH protein Twist specifies a subset [PDF]
, 2002 Differential activation of the Toll receptor leads to the formation of a broad Dorsal nuclear gradient that specifies at least three patterning thresholds of gene activity along the dorsoventral axis of precellular embryos.
Levine, Michael, Stathopoulos, Angelike
core
Polyphenol diet and exercise as neuroprotective factors in a Drosophila model of Alzheimer's disease
Animal Models and Experimental Medicine, EarlyView.Moderate exercise and low‐dose ellagic acid supplementation improved motor performance, learning, and longevity in a transgenic Drosophila model of Alzheimer's disease. Both interventions showed hormetic effects—that is, beneficial at low levels, but detrimental at higher intensities or doses.
Michelle Morgan +2 more
wiley +1 more source
PlantsThe WRKY gene family is ubiquitously distributed in plants, serving crucial functions in stress responses. Nevertheless, the structural organization and evolutionary dynamics of WRKY genes in cotton have not been fully elucidated.
Tianyu Dong +6 more
doaj +1 more source
Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9
Animal Models and Experimental Medicine, EarlyView.We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen +16 more
wiley +1 more source
Epigenetic Transcriptional Silencing and 5-Azacytidine-Mediated Reactivation of a Complex Transgene in Rice [PDF]
, 1997 Siva P. Kumpatla +3 more
openalex +1 more source
Annals of Neurology, EarlyView.Objective Mutations in TARDBP (encoding TDP‐43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.
Ziyaan A. Harji +10 more
wiley +1 more source