Results 181 to 190 of about 355,983 (382)

PDGFRα+DPP4+ Fibroblasts‐Macrophage Crosstalk Induces Orbital Fibrosis in Treatment‐Resistant Thyroid Eye Disease via the GAS6‐AXL Pathway

Advanced Science, EarlyView.
This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng, Jinwei Cheng, Guiling Liang, Xiaorui Wang, Yanwen Ge, Jiapei Liu, Luwei Cai, Hui Ying, Fenfen Wang, Jing Hu, Yufan Wang, Philipp E. Scherer, Ben Zhou, Mengle Shao, Fang Zhang   +14 more
wiley   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Induction of Interleukin 2‐Responsiveness in Thymocytes of the Transgenic Mice Carrying lck‐Transgene [PDF]

, 1993
Yoichi Moroi, Yasuhiro Koga, Kazuhiko Nakamura, Masumi Ohtsu, Genki Kimura, Kikuo Nomoto   +5 more
openalex   +1 more source

A Transmembrane Protein WAI‐B2 Confers Multiple Disease Resistance in Wheat by Activating Autoimmunity

Advanced Science, EarlyView.
Wheat production is under threat from multiple diseases. This study clones the wheat autoimmunity gene WAI‐B2 from an EMS‐induced mutant that encodes a distinct transmembrane protein conferring resistance to wheat rusts and powdery mildew ‐ two major diseases affecting wheat crops.
Wenling Li, Yongxing Chen, Lei Dong, Guanghao Guo, Huaizhi Zhang, Tao Shen, Gaojie Wang, Lingli Dong, Ping Lu, Miaomiao Li, Dan Qiu, Keyu Zhu, Beibei Li, Yikun Hou, Xuejia Cui, Baoge Huang, Fugang Yang, Hongkui Fu, Delin Li, Zhan Li, Jinghuang Hu, Yunfeng Qu, Huanhuan Lou, Shisheng Chen, Zaifeng Li, Ling Kang, Wuyun Yang, Chengguo Yuan, Hongjie Li, Yusheng Zhao, Zhiyong Liu, Haiyan Jia, Qiuhong Wu   +32 more
wiley   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

An HLA-DR1 Transgene Confers Susceptibility to Collagen-induced Arthritis Elicited with Human Type II Collagen [PDF]

, 1997
Edward F. Rosloniec, David Brand, Linda K. Myers, Karen B. Whittington, Marina L. Gumanovskaya, Dennis M. Zaller, Andrea Woods, Daniel M. Altmann, John Stuart, Andrew H. Kang   +9 more
openalex   +1 more source

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

Proceedings of the National Academy of Sciences of the United States of America, 1996
L. Naldini, U. Blömer, F. Gage, D. Trono, Inder M. Verma   +4 more
semanticscholar   +1 more source

Polo‐Like Kinase 1 Phosphorylation Tunes the Functional Viscoelastic Properties of the Centrosome Scaffold

Advanced Science, EarlyView.
To enable mitotic spindle assembly during cell division, centrosomes must bear tensile stresses generated by microtubule‐mediated pulling forces. Micro‐rheology reveals that PLK‐1 phosphorylation of the scaffold protein SPD‐5 tunes the viscoelasticity, size, and morphology of the centrosome scaffold in C. elegans.
Matthew Amato, June Ho Hwang, Manolo U. Rios, Nicole E. Familiari, Michael K. Rosen, Jeffrey B. Woodruff   +5 more
wiley   +1 more source

Precision Targeting of Myeloid Cells via Peptide Dendrimer‐Lipid Nanocarriers: A Novel Platform for Potent Cancer Immunotherapies

Advanced Science, EarlyView.
Precision targeting of the spleen and myeloid cells of the tumor microenvironment, with minimal hepatic delivery, is achieved using a modular peptide dendrimer‐lipid nanocarrier. Functional assays, transcriptomics, and rodent models validate this novel myeloid cell targeting nanocarrier as an efficacious immunotherapy, both as a cancer vaccine platform
Lawrence James Billing, Liam Martin, Tristan Henser‐Brownhill, Parisa Samangouei, Adam Leach, Phoebe Knight, Marina Apostolidou, Aaqib Ladak, Benita Nagel, Albert Kwok   +9 more
wiley   +1 more source

H-2Dp transgene alters natural killer cell specificity at the target and effector cell levels. Comparison with an H-2Dd transgene. [PDF]

, 1996
Charles L. Sentman, M Y Olsson-Alheim, Urban Lendahl, Klas Kärre   +3 more
openalex   +1 more source