Results 191 to 200 of about 176,088 (291)

5′ Transgenes drive leaky expression of 3′ transgenes in Cre-inducible bi-cistronic vectors

Yasuyuki Osanai, Yao Lulu Xing, Shinya Mochizuki, Kenta Kobayashi, Jihane Homman‐Ludiye, Amali Cooray, Jasmine Poh, Ayumu Inutsuka, Nobuhiko Ohno, Tobias D. Merson   +9 more
openalex   +1 more source

The transformer gene controls sexual development in Drosophila suzukii

Insect Science, EarlyView.
The transformer gene plays a key role in the genetic pathway for sexual development in Drosophila suzukii Abstract The genetic network of sex determination in the model organism Drosophila melanogaster was investigated in great detail. Such knowledge not only advances our understanding of the evolution and regulation of sexual dimorphism in insects ...
Ying Yan, Jing Zhao, Jonas Schwirz, Cristina Borghesi, Conghui Liu, Bo Liu, Wanqiang Qian, Fanghao Wan, Marc F. Schetelig   +8 more
wiley   +1 more source

Recent advances in site-specific transgene insertion into the maize genome using recombinases and genome editing endonucleases. [PDF]

Front Plant Sci
Basso MF, Pinto MS, Nonato JVA, Dante RA, Yassitepe JECT.   +4 more
europepmc   +1 more source

Genetic engineering for SIT application: a fruit fly‐focused review

Insect Science, EarlyView.
Abstract Sterile insect technique (SIT) has become a key component of efficient pest control. Fruit fly pests from the Drosophilidae and Tephritidae families pose a substantial and overwhelmingly increasing threat to the agricultural industry, aggravated by climate change and globalization among other contributors.
Serafima Davydova, Danheng Yu, Angela Meccariello   +2 more
wiley   +1 more source

Seeking stability for gene addition in inborn errors of metabolism. [PDF]

Mol Ther Nucleic Acids
von Beck T, Koeberl DD.
europepmc   +1 more source

Functional validation of a white pupae minimal gene construct in Ceratitis capitata (Diptera: Tephritidae)

Insect Science, EarlyView.
An intronless version of the white pupae (wp) gene was engineered to restore the wild type brown puparium color in white pupae phenotype mutants of the Mediterranean fruit fly, Ceratitis capitata. Functionality of the minimal gene version (mini‐wp) was verified in vivo, as one copy of mini‐wp successfully restored the wild type phenotype in homozygous ...
Lucas Henrique Figueiredo Prates, Roswitha A. Aumann, Inga Sievers, Tanja Rehling, Marc F. Schetelig   +4 more
wiley   +1 more source

Spatially controlled induction and regression of basal cell carcinoma, visualized by serial imaging in young and old mice. [PDF]

JID Innov
Pedersen EA, Grachtchouk M, Harms PW, Furgal AKC, Wilbert D, Hoover A, Hodgson DV, Fiehler K, Alam A, Lingam N, Wong SY, Verhaegen ME, Dlugosz AA.   +12 more
europepmc   +1 more source

AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo

, 2020
Chi Heon Kim, Colleen Oliver, Hamid Y. Dar, Hicham Drissi, Steven M. Presciutti   +4 more
openalex   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

Insect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li, Jin Cheng, Ya‐Ming Zou, Quan‐Chao Liu, Ding Zhu, Ce‐Jie Lan   +5 more
wiley   +1 more source

Enhancement of therapeutic transgene insertion for treatment of murine phenylketonuria. [PDF]

Mol Ther Nucleic Acids
Martinez MA, Richards DY, Winn SR, Baris AM, Vonada A, Harper L, Harding CO.   +6 more
europepmc   +1 more source