Results 201 to 210 of about 361,542 (380)

Technological breakthroughs in generating transgene-free and genetically stable CRISPR-edited plants

aBIOTECH, 2019
Yubing He, Yunde Zhao
semanticscholar   +1 more source

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

Clinical Pharmacology &Therapeutics, EarlyView.
We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker, Paul Matthias Diderichsen, Farina Hellmann, Timothy A. Yap, Ruth Plummer, Anthony W. Tolcher, Johann S. de Bono, Ioannis Gounaris, Zoltan Szucs, Astrid Zimmermann, Irina Kareva, Jayaprakasam Bolleddula, Annick Seithel‐Keuth, Giuseppe Locatelli, Marta Enderlin, Christine Hicking, Anup Zutshi, Wei Gao, Rainer Strotmann, Lisa Benincosa, Karthik Venkatakrishnan   +20 more
wiley   +1 more source

A General Approach to the Non-Invasive Imaging of Transgenes Using Cis-Linked Herpes Simplex Virus Thymidine Kinase

, 1999
Juri G. Gelovani, Arjun S. Joshi, James Callegari, Laura Lindsley, Revathi Joshi, Julius Balaton, Ronald Find, Steven M. Larso, Michel Sadelain, Ronald G. Blasberg   +9 more
openalex   +1 more source

Generation of Transgene-Free Semidwarf Maize Plants by Gene Editing of Gibberellin-Oxidase20-3 Using CRISPR/Cas9 [PDF]

, 2020
Jiaojiao Zhang, Xiaofeng Zhang, Rongrong Chen, Li Yang, Kaijian Fan, Yàn Liú, Guoying Wang, Zhenjing Ren, Yunjun Liu, Yunjun Liu, Yunjun Liu   +10 more
openalex   +1 more source

Effects of Human RelA Transgene on Murine Macrophage Inflammatory Responses [PDF]

, 2022
Stamatia Papoutsopoulou, Lorna Morris, Andrew Bayliff, Thomas Mair, Hazel England, Massimiliano Stagi, François Bergey, Mohammad Tauqeer Alam, Raheleh Sheibani‐Tezerji, Philip Rosenstiel, Werner Müller, Vítor A. P. Martins dos Santos, Barry J. Campbell   +12 more
openalex   +1 more source

Improvement of EPO Transgene Detection From Polymeric Dried Blood Spots for Antidoping Application

Drug Testing and Analysis, EarlyView.
This article presents an optimized protocol for gene doping detection. Starting from one spot DBS (20 μL), concentrated DNA was obtained and real‐time PCR parameters were adjusted for increased detection. Robust detection of 5000 copies/mL of transgene was validated for polymeric device TASSO M‐20.
Alexandre Marchand, Ingrid Roulland, Magnus Ericsson   +2 more
wiley   +1 more source

A novel imprinted transgene located near a repetitive element that exhibits allelic imbalance in DNA methylation during early development [PDF]

, 2014
Koji Uchiyama, Daisuke Watanabe, Michiko Hayasaka, Kazunori Hanaoka   +3 more
openalex   +1 more source

Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock‐ins

Developmental Dynamics, EarlyView.
Abstract Background The ability to generate endogenous Cre recombinase drivers using CRISPR‐Cas9 knock‐in technology allows lineage tracing, cell type‐specific gene studies, and in vivo validation of inferred developmental trajectories from phenotypic and gene expression analyses. This report describes endogenous zebrafish hand2 Cre and CreERT2 drivers
Zhitao Ming, Fang Liu, Hannah R. Moran, Robert L. Lalonde, Megan Adams, Nicole K. Restrepo, Parnal Joshi, Stephen C. Ekker, Karl J. Clark, Iddo Friedberg, Saulius Sumanas, Chunyue Yin, Christian Mosimann, Jeffrey J. Essner, Maura McGrail   +14 more
wiley   +1 more source

Promoter, transgene, and cell line effects in the transfection of mammalian cells using PDMAEMA-based nano-stars

, 2016
Alexander Raup, Valérie Jérôme, Ruth Freitag, Christopher V. Synatschke, Axel H. E. Müller   +4 more
openalex   +2 more sources

319. Improvement of Transgene Expression through the Direct Intrahepatic Injection of Adenoviral Vectors [PDF]

, 2004

openalex   +1 more source