Results 221 to 230 of about 360,625 (378)

Correction: Corrigendum: Rescue of neurophysiological phenotype seen in PRP null mice by transgene encoding human prion protein [PDF]

, 1995
Whittington, Miles A, Sidle, Katie CL, Gowland, Ian, Meads, Julie, Hill, Andrew F, Palmer, M, Jefferys, John GR, Collinge, John   +7 more
openalex   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Strong GAL4 expression compromises Drosophila fat body function. [PDF]

Genetics
Keith SA, Kalukin AA, Vargas Solivan DS, Smee MR, Lazzaro BP.   +4 more
europepmc   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Recent advances in site-specific transgene insertion into the maize genome using recombinases and genome editing endonucleases. [PDF]

Front Plant Sci
Basso MF, Pinto MS, Nonato JVA, Dante RA, Yassitepe JECT.   +4 more
europepmc   +1 more source

CRISPR/Cas9-Mediated Integration of Large Transgene into Pig CEP112 Locus [PDF]

, 2019
Guoling Li, Xianwei Zhang, Haoqiang Wang, Jianxin Mo, Cuili Zhong, Junsong Shi, Rong Zhou, Zicong Li, Huaqiang Yang, Zhenfang Wu, Dewu Liu   +10 more
openalex   +1 more source

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

Protocol for mapping insertion sites of Tol2 transgenes in zebrafish using TransTag. [PDF]

STAR Protoc
Wei X, Naidu V, Schneider P, Murphy PJ, Meng FW.   +4 more
europepmc   +1 more source

Ultrasound Backscatter Microscopy Image-Guided Intraventricular Gene Delivery at Murine Embryonic Age 9.5 and 10.5 Produces Distinct Transgene Expression Patterns at the Adult Stage [PDF]

, 2013
Jiwon Jang, Jyhyun Ahn, Nayeon Lee, Seong‐Tae Kim, Dae‐Hyuk Kweon, Jae Youl Cho, Kye Won Park, Sun‐Young Kim, Keejung Yoon   +8 more
openalex   +1 more source

Gene Therapy in Crohn's Disease: Current Preclinical Challenges and Future Translational Avenues. [PDF]

Biomedicines
Abdalla S, Brouquet A, Aron-Badin R, Bougnères P.   +3 more
europepmc   +1 more source