Results 231 to 240 of about 227,142 (341)

A novel transgenic reporter of extracellular acidification in zebrafish elucidates skeletal muscle T‐tubule pH regulation

Developmental Dynamics, EarlyView.
Abstract Disruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to
Leif R. Neitzel, Maya Silver, Aaron H. Wasserman, Samantha Rea, Charles C. Hong, Charles H. Williams   +5 more
wiley   +1 more source

RNA interference and turnover in plants -a complex partnership. [PDF]

Front Plant Sci
Krzyszton M, Kufel J, Zakrzewska-Placzek M.   +2 more
europepmc   +1 more source

Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori

Proceedings of the National Academy of Sciences of the United States of America, 2013
A. Tan, G. Fu, Li Jin, Q. Guo, Zhi-Qian Li, B. Niu, Z. Meng, N. Morrison, L. Alphey, Yongping Huang   +9 more
semanticscholar   +1 more source

A Practical Approach to Implementing ICH Q14: Tools for Analytical Quality by Design in Capillary Electrophoresis Method Development

ELECTROPHORESIS, EarlyView.
ABSTRACT The ICH Q14 guideline introduces a structured framework for analytical method development based on Analytical Quality by Design (AQbD) principles, aiming to ensure robust, reliable, and fit‐for‐purpose methods throughout the product lifecycle.
Ewoud van Tricht, Cari E. Sänger ‐ van de Griend   +1 more
wiley   +1 more source

Engineering tripartite gene editing machinery for highly efficient non-viral targeted genome integration. [PDF]

Nat Commun
Nam H, Xie K, Majumdar I, Wang J, Yang S, Starzyk J, Lee D, Shan R, Li J, Wu H.   +9 more
europepmc   +1 more source

Adeno-associated virus type 2-mediated transduction in primary human bone marrow-derived CD34+ hematopoietic progenitor cells: donor variation and correlation of transgene expression with cellular differentiation [PDF]

, 1997
Selvarangan Ponnazhagan, Pinku Mukherjee, Xiaolin Wang, Keyun Qing, Dagmar Marie Kube, Cathryn Mah, Chandrika Kurpad, Mervin C. Yöder, Edward F. Srour, Arun Srivastava   +9 more
openalex   +1 more source

Transgene-Free Genome Editing in Caenorhabditis elegans Using CRISPR-Cas

Genetics, 2013
Hui Chiu, H. Schwartz, I. Antoshechkin, P. Sternberg   +3 more
semanticscholar   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Regulation of Plant Genes with Exogenous RNAs. [PDF]

Int J Mol Sci
Dubrovina AS, Suprun AR, Kiselev KV.
europepmc   +1 more source

Adeno-Associated Virus Type 2-Mediated Gene Transfer: Role of Epidermal Growth Factor Receptor Protein Tyrosine Kinase in Transgene Expression [PDF]

, 1998
Cathryn Mah, Keyun Qing, Benjawan Khuntirat, Selvarangan Ponnazhagan, Xu-Shan Wang, Dagmar Marie Kube, Mervin C. Yöder, Arun Srivastava   +7 more
openalex   +1 more source