Results 241 to 250 of about 176,088 (291)

Plant‐produced encapsulin displays non‐typhoidal Salmonella enterica antigens and assembles into mosaic nanoparticles

The FEBS Journal, EarlyView.
This study investigates the potential of encapsulin as an antigen display platform for the development of a candidate Salmonella vaccine for poultry. Encapsulin constructs were transiently expressed in Nicotiana benthamiana where they accumulated to high levels.
Carly A. Charron, Angelo Kaldis, Shabnam Shamriz, Justin B. Renaud, Moussa S. Diarra, Christopher P. Garnham, Rima Menassa   +6 more
wiley   +1 more source

Reduced Cas9 transgene silencing by incorporation of intron sequences. [PDF]

Nat Commun
Arana S, Du PP, Vaughan-Jackson A, Enright N, Spees K, Valbuena R, Garcia CA, Nguyen T, Venida A, Seczynska M, Bintu L, Lehner PJ, Prolo LM, Bassik MC.   +13 more
europepmc   +1 more source

Multiple cis‐regulatory elements collaborate to control mdka expression in telencephalic neural stem cells of adult zebrafish during constitutive and regenerative neurogenesis

The FEBS Journal, EarlyView.
midkine‐a (mdka), a pan‐injury response gene in vertebrates, is precisely regulated in the zebrafish telencephalon by a modular cis‐regulatory architecture. This control ensures proper expression during development, adult brain homeostasis, and regeneration.
Jincan Chen, Masanari Takamiya, Agnes Hendriks, Tanja Beil, Csilla Várnai, Nicolas Diotel, Sepand Rastegar   +6 more
wiley   +1 more source

Rapid kinetics of AAV8 delivery of Vglut3 and hearing rescue shown day-by-day via matched IHC and ABR. [PDF]

Mol Ther Methods Clin Dev
Peters CWD, Hanlon K.
europepmc   +1 more source

Teleost‐specific ictacalcins exhibit similar structural organization, cation‐dependent activation, and transcriptional regulation as human S100 proteins

The FEBS Journal, EarlyView.
Calcium‐binding S100 proteins are important mediators of inflammation in humans. Distant members of this family have been recently discovered in teleost fish but their resemblance to human proteins has not been explored yet. This study demonstrates that zebrafish‐specific S100i1 and S100i2 (ictacalcins) possess identical structural organization and ...
Liz Hernández, Théo Paris, Maria Demou, Catherine Birck, Christina Begon‐Pescia, Juan Francisco Rodríguez Vidal, Sylwia D. Tyrkalska, Charlotte Bureau, Catherine Gonzalez, Juliette Gracia, Etienne Lelièvre, Victoriano Mulero, Mai Nguyen‐Chi, Laure Yatime   +13 more
wiley   +1 more source

Generation and characterization of a tamoxifen-inducible, Cre driver rat for transgene expression in microglia. [PDF]

Sci Rep
Glotfelty EJ, Coke LM, Hart EE, Rivell CA, Phan A, Greer BD, Svarcbahs R, Fielding E, Necarsulmer J, Fortuno LV, Vautier F, Gearhart PJ, Schoenbaum G, Richie CT, Harvey BK.   +14 more
europepmc   +1 more source

MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondria

The FEBS Journal, EarlyView.
Cells rely on mitochondria and peroxisomes to trigger antiviral defenses via the protein MAVS. This manuscript demonstrates that the robust production of antiviral effectors resulting from MAVS activation at peroxisomes is faster than at mitochondria due to a swifter oligomerization of this protein at peroxisomal membranes. These results underscore the
Bruno Ramos, Jéssica Sarabando, Mariana Marques, Jonathan C. Kagan, Daniela Ribeiro   +4 more
wiley   +1 more source

Advances in endothelial cell targeting by AAV vectors. [PDF]

Acta Biochim Pol
Cichon M, Jozkowicz A, Grochot-Przeczek A.   +2 more
europepmc   +1 more source

Limited roles of the miR‐17‐92 cluster in the regulation of T‐cell apoptosis

The FEBS Journal, EarlyView.
The pro‐apoptotic protein BIM shapes T‐cell survival and function, but how it is regulated remains unclear. In a mouse model lacking direct miR‐17‐92:Bim interactions, we observed a moderate reduction in Th17 CD4+ T cells. BIM levels were modestly increased in double‐positive thymocytes and naive CD8+ T cells, but this did not affect overall T‐cell ...
Katharina Hoppe, Johannes Woelk, Julia Benz, Sarah Spoeck, William J. Olson, Andreas Villunger, Natascha Hermann‐Kleiter, Verena Labi   +7 more
wiley   +1 more source

Transgene-free genome editing in citrus and poplar trees using positive and negative selection markers. [PDF]

Plant Cell Rep
Rocha DC, Omoregbee MO, Contiliani DF, Mandlik R, Li G, Mascoveto J, Coleman G, Culver JN, Leal DR, de Souza AA, Qi Y.   +10 more
europepmc   +1 more source