Local transgene expression and whole‐body transgenesis to model brain diseases in nonhuman primate [PDF]
, 2019 Lucie Chansel‐Debordeaux +1 more
openalex +1 more source
CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling
Med Research, EarlyView.CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li +8 more
wiley +1 more source
Rapid kinetics of AAV8 delivery of Vglut3 and hearing rescue shown day-by-day via matched IHC and ABR. [PDF]
Mol Ther Methods Clin DevPeters CWD, Hanlon K.
europepmc +1 more source
A novel imprinted transgene located near a repetitive element that exhibits allelic imbalance in
, 2014 Koji Uchiyama +3 more
openalex +1 more source
A conditional tissue-specific transgene expression system using inducible GAL4
Proceedings of the National Academy of Sciences of the United States of America, 2001 Thomas Osterwalder +3 more
semanticscholar +1 more source
Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids
Movement Disorders, EarlyView.Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley +1 more source
Characterization of NK603 transgene in a stacked maize variety
, 2015 Magali Castan
openalex +1 more source
S130 Exogenous Macrophages Are Retained in Mouse Lungs After Injury and Target Therapeutic Transgenes to the Injured Lung Parenchyma [PDF]
, 2012 Katrina McNulty +4 more
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Molecular genetics of development studied in the transgenic mouse. [PDF]
, 1989 Gruss, P., Westphal, H.
core +2 more sources
Modeling Obesity and Weight Loss in Mice Using Novel AAV Approaches
Obesity, EarlyView.ABSTRACT Objective This study utilized AAV gene delivery as an approach to induce and reverse hyperphagia in mice. We hypothesized that the delivery of orexigenic neuropeptides to the brain via AAV precipitates obesity and that the implementation of genetic switches to reverse transgene expression would elicit weight loss.
Hunter G. Sellers +12 more
wiley +1 more source