Results 251 to 260 of about 227,142 (341)

Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells

Nature Biotechnology, 2011
E. Papapetrou, Gabsang Lee, N. Malani, M. Setty, I. Rivière, Laxmi MS Tirunagari, K. Kadota, Shoshannah L. Roth, P. Giardina, A. Viale, C. Leslie, F. Bushman, L. Studer, M. Sadelain   +13 more
semanticscholar   +1 more source

Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing

Glia, EarlyView.
Hypothalamic astrocytes versus cortical astrocytes: are more glycolytic due to high Pkm2, Glut1 and Mct4 expression do not exhibit glutamate‐induced glycolysis detect glucose concentration variations via an AMPK sensor with altered lactate production. ABSTRACT In the hypothalamus, detection of energy substrates such as glucose is essential to regulate ...
Sarah Geller, Nadège Zanou, Sylviane Lagarrigue, Tamara Zehnder, Cathy Gouelle, Tania Santoro, Cendrine Repond, Paola Bezzi, Francesca Amati, Anne‐Karine Bouzier‐Sore, Ariane Sharif, Luc Pellerin   +11 more
wiley   +1 more source

Gender difference in pre-clinical liver-directed gene therapy with lentiviral vectors. [PDF]

Exp Biol Med (Maywood)
Guzman E, Khoo C, O'Connor D, Devarajan G, Iqball S, Souberbielle B, Mitrophanous K, Lad Y.   +7 more
europepmc   +1 more source

Systemic acquired silencing: transgene‐specific post‐transcriptional silencing is transmitted by grafting from silenced stocks to non‐silenced scions

EMBO Journal, 1997
J. Palauqui, T. Elmayan, J. Pollien, H. Vaucheret   +3 more
semanticscholar   +1 more source

Corrigendum: Building a Genetic Manipulation Tool Box for Orchid Biology: Identification of Constitutive Promoters and Application of CRISPR/Cas9 in the Orchid, Dendrobium officinale

Frontiers in Plant Science, 2017
Wen Wang, Wen Wang, Jing Cai, Jing Cai, Ling Kui, Ling Kui, Haitao Chen, Haitao Chen, Haitao Chen, Weixiong Zhang, Simei He, Zijun Xiong, Zijun Xiong, Yesheng Zhang, Yesheng Zhang, Yesheng Zhang, Liang Yan, Chaofang Zhong, Fengmei He, Junwen Chen, Peng Zeng, Guanghui Zhang, Shengchao Yang, Yang Dong, Yang Dong, Yang Dong   +25 more
doaj   +1 more source

Binding of Transcriptional Activator to Silent Loci Causes Their Detachment from the Nuclear Lamina in <i>Drosophila</i> Neurons and Salivary Gland Cells. [PDF]

Int J Mol Sci
Simonov RA, Olenkina OM, Nenasheva VV, Abramov YA, Lavrov SA, Fedotova AA, Shevelyov YY.   +6 more
europepmc   +1 more source

A clinician's guide to AAV production - How manufacturing platforms shape vector properties. [PDF]

Med Genet
Magnus J, Käsbach J.
europepmc   +1 more source

SOX10, MITF, and microRNAs: Decoding their interplay in regulating melanoma plasticity

International Journal of Cancer, EarlyView.
Abstract Recent studies show that the dysregulation of the transcription factor SOX10 is essential for the development and progression of melanoma. MicroRNAs (miRNAs) can regulate the expression of transcription factors at the post‐transcriptional level. The interactions between SOX10 and its targeting miRNAs form network motifs such as feedforward and
Xin Lai, Chunyan Luan, Zhesi Zhang, Anja Wessely, Markus V. Heppt, Carola Berking, Julio Vera   +6 more
wiley   +1 more source

Generation of transgene-free genome-edited carrot plants using CRISPR/Cas9-RNP complexes. [PDF]

Plant Cell Rep
Yarra R, Krysan PJ.
europepmc   +1 more source

Use of Mitochondrial Delayed Luminescence Measurements From Brain Tissue to Optimize Photobiomodulation Prarameters in Alzheimer's Disease Mice

Journal of Biophotonics, EarlyView.
Photobiomodulation (808 nm laser, optimized at 80 Hz, 30% duty cycle) significantly enhances mitochondrial function, reduces β‐amyloid deposition, and attenuates microglial activation in a 5XFAD Alzheimer's mouse model. Delayed luminescence serves as a novel bioenergetic marker, linking improved mitochondrial efficiency to cognitive and ...
Hong Bae Kim, Chang Kyu Sung
wiley   +1 more source