Results 251 to 260 of about 355,983 (382)

Systemic gene therapy: biodistribution and long-term expression of a transgene in mice. [PDF]

, 1995
Alain R. Thierry, Yanto Lunardi-Iskandar, Joseph Bryant, P Rabinovich, R C Gallo, L C Mahan   +5 more
openalex   +1 more source

Conserved Phosphorylation of the Myosin1e TH1 Domain Impacts Membrane Association and Function in Yeast and Worms

Cytoskeleton, EarlyView.
ABSTRACT Cells have an intrinsic ability to rapidly respond to environmental change to regulate cell cycle progression and membrane organisation, thereby affecting cell growth and division. The actin cytoskeleton is a highly dynamic complex of proteins that can rapidly reorganise to change the growth pattern of a cell.
Holly R. Brooker, Karen Baker, Marina Ezcurra, Philippe P. Laissue, Lin Wang, Michael A. Geeves, Jennifer M. Tullet, Daniel P. Mulvihill   +7 more
wiley   +1 more source

Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation. [PDF]

, 1995
Kalpit A. Vora, Tim Manser
openalex   +1 more source

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

Science, 2009
Junying Yu, Kejin Hu, Kimberley Smuga-Otto, Shulan Tian, R. Stewart, I. Slukvin, James A. Thomson   +6 more
semanticscholar   +1 more source

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

Clinical Pharmacology &Therapeutics, EarlyView.
We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker, Paul Matthias Diderichsen, Farina Hellmann, Timothy A. Yap, Ruth Plummer, Anthony W. Tolcher, Johann S. de Bono, Ioannis Gounaris, Zoltan Szucs, Astrid Zimmermann, Irina Kareva, Jayaprakasam Bolleddula, Annick Seithel‐Keuth, Giuseppe Locatelli, Marta Enderlin, Christine Hicking, Anup Zutshi, Wei Gao, Rainer Strotmann, Lisa Benincosa, Karthik Venkatakrishnan   +20 more
wiley   +1 more source

A Preliminary Study on the Accuracy of MRI-Guided Thalamic Infusion of AAV2-GFP and Biodistribution Analysis Using Cryo-Fluorescence Tomography in Nonhuman Primates. [PDF]

Pharmaceutics
Salegio EA, Espinosa R, Smith GR, Shoshan D, Silva M, White E, McDonald J.   +6 more
europepmc   +1 more source

Transgene-induced production of IL-4 alters the development and collagen expression of T helper cell 1-type pulmonary granulomas. [PDF]

, 1997
Nicholas W. Lukacs, CL Addison, Jack Gauldie, Felicia L. Graham, K.J. Simpson, Robert M. Strieter, Kelly Warmington, Stephen W. Chensue, S L Kunkel   +8 more
openalex   +1 more source

Using translational enhancers to increase transgene expression in Drosophila

Proceedings of the National Academy of Sciences of the United States of America, 2012
B. Pfeiffer, J. Truman, G. Rubin
semanticscholar   +1 more source

Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock‐ins

Developmental Dynamics, EarlyView.
Abstract Background The ability to generate endogenous Cre recombinase drivers using CRISPR‐Cas9 knock‐in technology allows lineage tracing, cell type‐specific gene studies, and in vivo validation of inferred developmental trajectories from phenotypic and gene expression analyses. This report describes endogenous zebrafish hand2 Cre and CreERT2 drivers
Zhitao Ming, Fang Liu, Hannah R. Moran, Robert L. Lalonde, Megan Adams, Nicole K. Restrepo, Parnal Joshi, Stephen C. Ekker, Karl J. Clark, Iddo Friedberg, Saulius Sumanas, Chunyue Yin, Christian Mosimann, Jeffrey J. Essner, Maura McGrail   +14 more
wiley   +1 more source

Durable tissue-specific transgene expression in newborn mice following intraperitoneal delivery of non-cytotoxic HSV vectors. [PDF]

Mol Ther Methods Clin Dev
Miyagawa Y, Maruyama M, Sakai A, Sato Y, Shimizu M, Kuroda S, Hayashita-Kinoh H, Yamamoto M, Hashizume R, Suzuki H, Cohen JB, Glorioso JC, Okada T.   +12 more
europepmc   +1 more source