Results 271 to 280 of about 355,983 (382)

A conditional tissue-specific transgene expression system using inducible GAL4

Proceedings of the National Academy of Sciences of the United States of America, 2001
Thomas Osterwalder, Kenneth S. Yoon, B. White, H. Keshishian   +3 more
semanticscholar   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Disruption of electrophysiological rhythms and memory impairment in an Alzheimer's transgenic rat model. [PDF]

Alzheimers Res Ther
Tao X, Kumar U, Wang M, Manglani K, Zhu C, Jones MR, Bombino A, Bragin A, Cole G, Vossel K, Engel J, Frautschy SA, Li L.   +12 more
europepmc   +1 more source

Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors.

, 1997
Christina Addison, Mary Hitt, D Kunsken, Frank L. Graham   +3 more
openalex   +1 more source

Adeno-Associated Virus Type 2-Mediated Gene Transfer: Role of Epidermal Growth Factor Receptor Protein Tyrosine Kinase in Transgene Expression [PDF]

, 1998
Cathryn Mah, Keyun Qing, Benjawan Khuntirat, Selvarangan Ponnazhagan, Xu-Shan Wang, Dagmar Marie Kube, Mervin C. Yöder, Arun Srivastava   +7 more
openalex   +1 more source

Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori

Proceedings of the National Academy of Sciences of the United States of America, 2013
A. Tan, G. Fu, Li Jin, Q. Guo, Zhi-Qian Li, B. Niu, Z. Meng, N. Morrison, L. Alphey, Yongping Huang   +9 more
semanticscholar   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Reduced insulin/IGF-1 signaling and loss of <i>pals-22</i> promote repetitive DNA silencing in <i>C. elegans</i>. [PDF]

MicroPubl Biol
Ewe CK, Teichman G, Rechavi O.
europepmc   +1 more source

Efficient Liver-specific Deletion of a Floxed Human Angiotensinogen Transgene by Adenoviral Delivery of Cre Recombinasein Vivo [PDF]

, 1999
David E. Stec, Robin L. Davisson, Ronald E. Haskell, Beverly L. Davidson, Curt D. Sigmund   +4 more
openalex   +1 more source

Transgene-Free Genome Editing in Caenorhabditis elegans Using CRISPR-Cas

Genetics, 2013
Hui Chiu, H. Schwartz, I. Antoshechkin, P. Sternberg   +3 more
semanticscholar   +1 more source