Results 271 to 280 of about 293,415 (335)

A clinician's guide to AAV production - How manufacturing platforms shape vector properties. [PDF]

Med Genet
Magnus J, Käsbach J.
europepmc   +1 more source

Recent Advancements in the Treatment of Age‐Related Macular Degeneration

Med Research, EarlyView.
ABSTRACT Age‐related macular degeneration (AMD) is a prevalent cause of visual impairment and blindness among the elderly. AMD can be categorized into two subtypes: “wet” and “dry.” Current treatments for wet AMD mainly involve anti‐vascular endothelial growth factor (VEGF) drugs, and there are three U.S.
Shan Liu, Danyang Lv, Junran Sun, Huixun Jia, Fang Zheng, Felipe Pereira, Siddharth Narendran, Zhenyu Dong, Haiyun Liu, Shunxiang Gao, Peirong Huang   +10 more
wiley   +1 more source

Mass photometry as a robust method for characterizing adeno-associated virus critical quality attributes in gene therapy vector. [PDF]

Mol Ther Nucleic Acids
Wang G, Yu L, Qin X, Zhou Z, Zhou Y, Liang C.   +5 more
europepmc   +1 more source

Generation of transgene-free genome-edited carrot plants using CRISPR/Cas9-RNP complexes. [PDF]

Plant Cell Rep
Yarra R, Krysan PJ.
europepmc   +1 more source

A linamarase transgene controlled by heatshock creates a pro-toxin activation system in <i>Drosophila melanogaster</i> . [PDF]

MicroPubl Biol
Carey L, Malka O, Morin S, Robin C.
europepmc   +1 more source

Activation of PI3K and deletion of p53 in keratin 15‐expressing mouse mammary cells induces tumor heterogeneity and plasticity modeling metaplastic breast cancer

The Journal of Pathology, EarlyView.
Abstract Although relatively rare, metaplastic breast cancer responds poorly to traditional therapies compared to other subtypes. Accordingly, there is a need for novel animal models to understand its pathogenesis and plasticity. Since alterations in PIK3CA and TP53 genes are common in metaplastic breast cancer, we generated a mouse model of ...
Khoa A Nguyen, Lauren E McLemore, Yao Ke, Lisa N DePledge, Lynelle P Smith, Li Bian, John D Aleman, David Debretsion, Erica Wong, Nicole Manning, Xiao‐Jing Wang, Christian D Young   +11 more
wiley   +1 more source

Population Cellular Kinetics of Idecabtagene Vicleucel in Patients with Triple-Class-Exposed Relapsed/Refractory Multiple Myeloma. [PDF]

Clin Pharmacokinet
Wu F, Zhou J, Zheng X, Masilamani M, Cheng Y, Caia A, Cook M, Piasecki J, Lamba M.   +8 more
europepmc   +1 more source

Hemophilia A: An Ideal Disease for Prenatal Therapy

Prenatal Diagnosis, EarlyView.
ABSTRACT Hemophilia A (HA) is the most common inherited coagulation defect. Current state‐of‐the‐art treatment consists of frequent administration of prophylactic infusions of coagulation factor VIII (FVIII) protein or bispecific antibodies that replace the cofactor function of FVIIIa to maintain hemostasis. However, these treatments are far from ideal,
Christopher D. Porada, Anthony Atala, Graça Almeida‐Porada   +2 more
wiley   +1 more source

Developing the next-generation of adenoviral vector vaccines. [PDF]

Hum Vaccin Immunother
Sampson AT, Hlaváč M, Gillman ACT, Douradinha B, Gilbert SC.   +4 more
europepmc   +1 more source

Meta‐analysis on effects of Bt‐maize on nontarget invertebrates – Data transportability across continents

PLANTS, PEOPLE, PLANET, EarlyView.
Maize varieties producing insecticidal proteins from Bacillus thuringiensis (Bt) have become an important component of integrated pest management worldwide. For regulatory approval of such plants, risks to the environment need to be assessed. To make such assessments less expensive and time‐consuming, conclusions drawn from data collected in one region
Michael Meissle, Steven E. Naranjo, Jörg Romeis   +2 more
wiley   +1 more source