Results 271 to 280 of about 360,625 (378)

Use of Fidanacogene Elaparvovec, a Gene Therapy Vector, to Deliver a Stable, Fully Functional Human Factor IX Transgene for the Treatment of Hemophilia B: A Combined Analysis of Safety [PDF]

Ben Samelson-Jones, Laurent Frenzel, Kaan Kavaklı, Adam Cuker, Jerome Teitel, Pengling Sun, Lisa J. Wilcox, Francesca Biondo, Benjamin Hutter, John McKay, Delphine Agathon, Frank Plonski   +11 more
openalex   +1 more source

576. Highly Efficient Transgene Expression Using Pseudotyped Adeno Associated Virus Type I in the Mammalian Brain [PDF]

, 2002

openalex   +1 more source

Field resistance of orange fruit to citrus black spot and citrus canker in D‐limonene synthase downregulated trees

Pest Management Science, EarlyView.
Genetically modified (GM) sweet‐oranges with downregulated CitMTSE1 gene showed reduced citrus black spot severity and citrus canker incidence, confirming terpene modulation as a promising strategy for sustainable field citrus disease resistance. Abstract BACKGROUND Citrus black spot (CBS), caused by Phyllosticta citricarpa, and citrus canker (CC ...
Geraldo José Silva‐Junior, Thiago de Aguiar Carraro, Rafael Angelo Gonçalves Smirne, Rafaele Regina Moreira, Nelson Arno Wulff, Leandro Peña, Rodrigo Facchini Magnani, Takehiko Shimada, Franklin Behlau   +8 more
wiley   +1 more source

Highly efficient transgenesis mediated by Tip100 transposon system in medaka. [PDF]

Transgenic Res
Tanaka Y, Seki T, Hoshino A, Ansai S.
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Effects of BRCA1 Transgene Expression on Murine Mammary Gland Development and Mutagen-Induced Mammary Neoplasia

, 2007
Cindy J. Yee Arichika Hoshino
openalex   +1 more source

3D Quantification of Viral Transduction Efficiency in Living Human Retinal Organoids

Small Methods, EarlyView.
Optimization of viral vectors and their testing in human tissue is crucial to gene therapy development. Conventional technologies to assess virus transduction either lack spatial or temporal information. Here, spatiotemporal mapping of virus transduction in living retinal tissue is introduced, levering fluorescence imaging and machine learning‐based ...
Teresa S. Rogler, Katja A. Salbaum, Achim T. Brinkop, Selina M. Sonntag, Rebecca James, Elijah R. Shelton, Alina Thielen, Roland Rose, Sabrina Babutzka, Thomas Klopstock, Stylianos Michalakis, Friedhelm Serwane   +11 more
wiley   +1 more source

Speed Breeding Transgenic American Chestnut Trees Toward Restoration. [PDF]

Plant Direct
Klak T, Pilkey H, May VG, Matthews D, Oakes AD, Tan EH, Newhouse AE.   +6 more
europepmc   +1 more source

LKB1 deletion with the RIP2.Cre transgene modifies pancreatic β-cell morphology and enhances insulin secretion in vivo

, 2010
Gao Sun, Andrei I. Tarasov, James McGinty, P. M. W. French, Angela McDonald, Isabelle Leclerc, Guy A. Rutter   +6 more
openalex   +2 more sources

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source