Results 281 to 290 of about 355,983 (382)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Transgene-Killer-CRISPR version 2 (TKC2) eliminates occasional transgene escape by coupling with a RUBY reporter. [PDF]

Plant Biotechnol J
Zhu M, Yan L, Zhan Z, Chen H, Wang D, Xu M, Zheng Z, Zhang Y, Yang N, Wu J, Zhan H, Tian Y, Xiong L, He Y.   +13 more
europepmc   +1 more source

Overexpression of a Rrp1 transgene reduces the somatic mutation and recombination frequency induced by oxidative DNA damage in Drosophila melanogaster.

, 1996
Akos Szakmary, Shu Huang, David T. Chang, Philip A. Beachy, M Sander   +4 more
openalex   +1 more source

The risk of crop transgene spread [PDF]

, 1996
Thomas Raundahl Mikkelsen, Bente Andersen, Rikke Bagger Jørgensen   +2 more
openalex   +1 more source

Transgene expression up to 7 years in nonhuman primates following hepatic transduction with helper-dependent adenoviral vectors.

Human Gene Therapy, 2013
N. Brunetti‐Pierri, T. Ng, D. Iannitti, W. Cioffi, Gary E. Stapleton, Mark Law, J. Breinholt, D. Palmer, Nathan C Grove, K. Rice, Cassondra Bauer, M. Finegold, A. Beaudet, C. Mullins, P. Ng   +14 more
semanticscholar   +1 more source

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

AAV microdystrophin gene replacement therapy for Duchenne muscular dystrophy: progress and prospects. [PDF]

Gene Ther
Chwalenia K, Feng VY, Hemmer N, Friedrichsen HJ, Vorobieva I, Wood MJA, Roberts TC.   +6 more
europepmc   +1 more source

A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny

Stem Cells, 2013
Nils Pfaff, N. Lachmann, Mania Ackermann, Saskia Kohlscheen, C. Brendel, T. Maetzig, H. Niemann, Michael N. Antoniou, M. Grez, A. Schambach, T. Cantz, Thomas Moritz   +11 more
semanticscholar   +1 more source

Marine Algae‐Derived Bioactives: A Sustainable Resource for the Food and Agriculture Industries

Food Frontiers, EarlyView.
Algae are widely used in food and agriculture due to their bioactive compounds and are an eco‐friendly natural preservative and low carbon farming method. However, the problems regarding safety and acceptance still remain as tools like nanotechnology make improvements.
Sara Chadorshabi, Maryam Mohammadi, Ehsan Shamloo, Maryam Mahmoudzadeh   +3 more
wiley   +1 more source

Correction: The circadian genes are required in DAL neurons for <i>Drosophila</i> long-term memory formation. [PDF]

Front Neurosci
Yin JCP, Cui E, Johnstone PS, Top D, Boekhoff-Falk G, Zhou H.   +5 more
europepmc   +1 more source