Results 21 to 30 of about 176,088 (291)

A Potential Method for Rapid Screening of Amphioxus Founder Harboring Germline Mutation and Transgene

Frontiers in Cell and Developmental Biology, 2021
Amphioxus is a promising model organism for understanding the origin and evolution of vertebrates due to its basal phylogenetic position among chordates.
Jiaqi Zou, Xiaotong Wu, Chenggang Shi, Yanhong Zhong, Lei Zhang, Qiuning Yan, Liuru Su, Guang Li   +7 more
doaj   +1 more source

Cloning, expression and functional analysis of the SOC1 homologous gene in pak choi (Brassica rapa ssp. Chinensis makino)

Biotechnology & Biotechnological Equipment, 2022
Flowering transition is important in plant growth and development, and the SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1) gene belongs to the MADS-box gene family, which is an integrator involved in the regulation of flower formation in plants.
Xuan Li, Amin Ping, Xianhui Qi, Meilan Li, Leiping Hou   +4 more
doaj   +1 more source

Preclinical Evaluation of the Oncolytic Vaccinia Virus TG6002 by Translational Research on Canine Breast Cancer

Molecular Therapy: Oncolytics, 2020
Oncolytic virotherapy is a promising therapeutic approach for the treatment of cancer. TG6002 is a recombinant oncolytic vaccinia virus deleted in the thymidine kinase and ribonucleotide reductase genes and armed with the suicide gene FCU1, which encodes
Jérémy Béguin, Johann Foloppe, Christelle Maurey, Eve Laloy, Julie Hortelano, Virginie Nourtier, Christelle Pichon, Sandrine Cochin, Pascale Cordier, Hélène Huet, Eric Quemeneur, Bernard Klonjkowski, Philippe Erbs   +12 more
doaj   +1 more source

GmSTK12 Participates in Salt Stress Resistance in Soybean

Agronomy, 2023
Soybean (Glycine max (Linn.) Merr.) is a widely-cultivated crop, the yield of which is markedly affected by adverse environmental conditions. Soil salinization, in particular, has led to the degradation of agricultural land, resulting in poor plant ...
Yang Liu, Jingwen Zhou, Yun Chen, Xue Yang, Shuang Jiao, Huimin Zhang, Xiaofei Ma, Hong Zhai, Xi Bai   +8 more
doaj   +1 more source

A meta-analysis of the antiviral activity of the HBV-specific immunotherapeutic TG1050 confirms its value over a wide range of HBsAg levels in a persistent HBV pre-clinical model

Human Vaccines & Immunotherapeutics, 2018
Pre-clinical models mimicking persistent hepatitis B virus (HBV) expression are seldom, do not capture all features of a human chronic infection and due to their complexity, are subject to variability.
Roland Kratzer, Benoît Sansas, Karine Lélu, Alexei Evlachev, Doris Schmitt, Nathalie Silvestre, Geneviève Inchauspé, Perrine Martin   +7 more
doaj   +1 more source

Compensation of Wild Plants Weakens the Effects of Crop-Wild Gene Flow on Wild Rice Populations

Frontiers in Plant Science, 2021
Crop-wild gene flow may alter the fitness of the recipient i.e., crop-wild hybrids, then potentially impact wild populations, especially for the gene flow carrying selective advantageous crop alleles, such as transgenes conferring insect resistance ...
Dongxin Ouyang, Shanshan Dong, Shanshan Dong, Manqiu Xiao, Jianling You, Yao Zhao, Yuguo Wang, Wenju Zhang, Ji Yang, Zhiping Song   +9 more
doaj   +1 more source

Heterologous Production and Evaluation of the Biological Activity of Cystatin-B From the Red Piranha Pygocentrus nattereri

Frontiers in Genetics, 2022
Cystatin proteins are known to form a superfamily of cysteine protease inhibitors, which play a key role in protein degradation and are related to different physiological processes, such as development and immunity.
Juan Antonio Ramirez Merlano, Daniela Volcan Almeida   +1 more
doaj   +1 more source

Cowpox Virus: A New and Armed Oncolytic Poxvirus

Molecular Therapy: Oncolytics, 2017
Oncolytic virus therapy has recently been recognized as a promising new therapeutic approach for cancer treatment. In this study, we are proposing for the first time to evaluate the in vitro and in vivo oncolytic capacities of the Cowpox virus (CPXV). To
Marine Ricordel, Johann Foloppe, Christelle Pichon, Nathalie Sfrontato, Delphine Antoine, Caroline Tosch, Sandrine Cochin, Pascale Cordier, Eric Quemeneur, Christelle Camus-Bouclainville, Stéphane Bertagnoli, Philippe Erbs   +11 more
doaj   +1 more source

Stability of the HSV-2 US-6 Gene in the del II, del III, CP77, and I8R-G1L Sites in Modified Vaccinia Virus Ankara After Serial Passage of Recombinant Vectors in Cells

Vaccines, 2020
The modified vaccinia virus Ankara (MVA), a severely attenuated strain of vaccinia virus, is a promising vector platform for viral-vectored vaccine development because of its attributes of efficient transgene expression and safety profile, among others ...
Vajini N. Atukorale, Jerry P. Weir, Clement A. Meseda   +2 more
doaj   +1 more source

TG6002 oncolytic vaccinia virus and chemotherapy synergy: a promising strategy for pancreatic ductal adenocarcinoma

Frontiers in Microbiology
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant cancer characterized by poor prognosis and limited treatment options, often associated with significant toxicity.
Johann Foloppe, Isabelle Farine, Christelle Pichon, Juliette Kempf, Julie Hortelano, Baptiste Moreau, Sandrine Cochin, Armelle Takeda, Patrick Pessaux, Patrick Pessaux, Philippe Erbs   +10 more
doaj   +1 more source