Results 21 to 30 of about 4,875 (50)

A Potential Method for Rapid Screening of Amphioxus Founder Harboring Germline Mutation and Transgene

Frontiers in Cell and Developmental Biology, 2021
Amphioxus is a promising model organism for understanding the origin and evolution of vertebrates due to its basal phylogenetic position among chordates.
Jiaqi Zou, Xiaotong Wu, Chenggang Shi, Yanhong Zhong, Lei Zhang, Qiuning Yan, Liuru Su, Guang Li   +7 more
doaj   +1 more source

GmSTK12 Participates in Salt Stress Resistance in Soybean

Agronomy, 2023
Soybean (Glycine max (Linn.) Merr.) is a widely-cultivated crop, the yield of which is markedly affected by adverse environmental conditions. Soil salinization, in particular, has led to the degradation of agricultural land, resulting in poor plant ...
Yang Liu, Jingwen Zhou, Yun Chen, Xue Yang, Shuang Jiao, Huimin Zhang, Xiaofei Ma, Hong Zhai, Xi Bai   +8 more
doaj   +1 more source

Stability of the HSV-2 US-6 Gene in the del II, del III, CP77, and I8R-G1L Sites in Modified Vaccinia Virus Ankara After Serial Passage of Recombinant Vectors in Cells

Vaccines, 2020
The modified vaccinia virus Ankara (MVA), a severely attenuated strain of vaccinia virus, is a promising vector platform for viral-vectored vaccine development because of its attributes of efficient transgene expression and safety profile, among others ...
Vajini N. Atukorale, Jerry P. Weir, Clement A. Meseda   +2 more
doaj   +1 more source

An auxin-inducible, GAL4-compatible, gene expression system for Drosophila

eLife, 2022
The ability to control transgene expression, both spatially and temporally, is essential for studying model organisms. In Drosophila, spatial control is primarily provided by the GAL4/UAS system, whilst temporal control relies on a temperature-sensitive ...
Colin D McClure, Amira Hassan, Gabriel N Aughey, Khushbakht Butt, Alicia Estacio-Gómez, Aneisha Duggal, Chee Ying Sia, Annika F Barber, Tony D Southall   +8 more
doaj   +1 more source

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation

Scientific Reports, 2017
Plasminogen activator inhibitor-1 (PAI-1) is known to protect mice against cardiac fibrosis. It has been speculated that PAI-1 may regulate cardiac fibrosis by inactivating urokinase-type plasminogen activator (uPA) and ultimately plasmin (Pm) generation.
Kamlesh K. Gupta, Deborah L. Donahue, Mayra J. Sandoval-Cooper, Francis J. Castellino, Victoria A. Ploplis   +4 more
doaj   +1 more source

Long-Term Efficacy and Safety of RNAi-Mediated Virus Resistance in ‘HoneySweet’ Plum

Frontiers in Plant Science, 2021
Interfering RNA technology has been established as an effective strategy to protect plants against viral infection. Despite this success, interfering RNA (RNAi) has rarely been applied due to the regulatory barriers that confront genetically engineered ...
Khushwant Singh, Khushwant Singh, Ann M. Callahan, Brenda J. Smith, Tadeusz Malinowski, Tadeusz Malinowski, Ralph Scorza, Jana Jarošová, Eva Beoni, Jaroslav Polák, Jiban Kumar Kundu, Chris Dardick   +11 more
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TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody, favors tumor regression via profound immune remodeling of the tumor microenvironment

Journal for ImmunoTherapy of Cancer
Background TG6050 was designed as an improved oncolytic vector, combining the intrinsic properties of vaccinia virus to selectively replicate in tumors with the tumor-restricted expression of recombinant immune effectors to modify the tumor immune ...
Laetitia Fend, Eric Quemeneur, Jean-Baptiste Marchand, Nathalie Silvestre, Johann Foloppe, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fadi Azar, Christelle Demeusoit, Clémentine Spring-Giusti   +10 more
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Nucleic Acid-Based Approaches for Tumor Therapy

Cells, 2020
Within the last decade, the introduction of checkpoint inhibitors proposed to boost the patients’ anti-tumor immune response has proven the efficacy of immunotherapeutic approaches for tumor therapy.
Simone Hager, Frederic Julien Fittler, Ernst Wagner, Matthias Bros   +3 more
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Oncolytic virotherapy with intratumoral injection of vaccinia virus TG6002 and 5-fluorocytosine administration in dogs with malignant tumors

Molecular Therapy: Oncolytics, 2023
TG6002 is an oncolytic vaccinia virus expressing FCU1 protein, which converts 5-fluorocytosine into 5-fluorouracil. The study objectives were to assess tolerance, viral replication, 5-fluorouracil synthesis, and tumor microenvironment modifications to ...
Jérémy Béguin, Eve Laloy, Sandrine Cochin, Murielle Gantzer, Isabelle Farine, Christelle Pichon, Baptiste Moreau, Johann Foloppe, Jean-Marc Balloul, Christelle Machon, Jérôme Guitton, Dominique Tierny, Bernard Klonjkowski, Eric Quéméneur, Christelle Maurey, Philippe Erbs   +15 more
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Experimental mouse models for translational human cancer research

Frontiers in Immunology, 2023
The development and growth of tumors remains an important and ongoing threat to human life around the world. While advanced therapeutic strategies such as immune checkpoint therapy and CAR-T have achieved astonishing progress in the treatment of both ...
Yinxi Zhou, Jinghua Xia, Shuonan Xu, Tao She, Yanning Zhang, Ying Sun, Miaomiao Wen, Tao Jiang, Yanlu Xiong, Jie Lei   +9 more
doaj   +1 more source