Results 291 to 300 of about 360,625 (378)

Establishment of a second-generation transgenic marmoset with germline transmission that models polyglutamine disease.

Dis Model Mech
Minakawa EN, Owari K, Nogami N, Nakatani T, Koizumi M, Kawanobe A, Saga Y, Kudo M, Noguchi S, Hanakawa T, Hori Y, Numazawa H, Takeuchi T, Katakai Y, Saito R, Nagai Y, Saito Y, Tomioka I, Seki K.   +18 more
europepmc   +1 more source

Inhibition of immune response reduces pathology in dorsal root ganglia and peripheral nerves in cynomolgus macaques following AAV gene therapy. [PDF]

Mol Ther Methods Clin Dev
Grubor B, Henry KL, Chan SJ, Sheehan M, Shah A, Pellerin A, Bai J, Nadella P, Bommegowda S, Cullen P, Tien E, Chen V, van der Munnik NP, White-Hunt S, Plowey ED, Hamann S, Guise AJ, Xu S, Kirkland M, Doherty J, Lyashenko E, Bhat G, Glajch K, Lo SC, Gianni D, Clarner P, Gagnon J, Chu J, Nambiar K, Lulla M, Zheng F, Weldeab A, Bartlett D, Gutnick A, Reynolds T, Zhu K, Huh D, Carlile TM, Fikes J, Trapa P, Suh J, Morris D, Burkly L.   +42 more
europepmc   +1 more source

Sequence and expression analysis of potential spermatogenesis‐specific gene cognates in the Caribbean fruit fly, Anastrepha suspensa

Insect Science, EarlyView.
Abstract The sterile insect technique (SIT) is a highly effective biologically‐based method for the suppression of many insect pest populations. SIT efficacy could be improved by methods of male sterilization that avoid the use of irradiation that can result in diminished fitness and mating competitiveness.
Alfred M. Handler, Richard B. Furlong, Chao Chen, Daniel A. Hahn   +3 more
wiley   +1 more source

Generation and characterization of a humanized <i>ACE2</i> rat model for the study of SARS-CoV-2 and COVID-19. [PDF]

Front Microbiol
Olson RM, Nabli H, Gentry BA, Davis DJ, Franklin CL, Shaw ML, Bryda EC.   +6 more
europepmc   +1 more source

DsiRNA‐mediated silencing of Ceratitis capitata transformer or transformer‐2 leads to masculinization of XX embryos and systemic gene silencing in ovaries

Insect Science, EarlyView.
We carried out functional studies using Dicer‐substrate small interfering RNAs (DsiRNAs), targeting the sex determination genes Cctransformer (Cctra) and Cctransformer‐2 (Cctra‐2) in the Mediterranean fruit fly (Ceratitis capitata). Microinjection of DsiRNAs into XX embryos (0‐1 h old) rapidly triggered the expression of male‐specific Cctra isoforms ...
Gennaro Volpe, Sarah Maria Mazzucchiello, Domenico De Falco, David Torrente, Stefania Liguori, Noemi Rosati, Dora Baccaro, Michela Mazzeo, Fulvio Bertolotto, Harshini Sangle, Ennio Giordano, Angela Carfora, Francesca Lucibelli, Marianna Varone, Paola Di Lillo, Hugo Diego Perdomo, Mariangela Bonizzoni, Serena Aceto, Marco Salvemini, Molly Duman‐Scheel, Giuseppe Saccone   +20 more
wiley   +1 more source

A rapid and dynamic role for FMRP in the plasticity of adult neurons. [PDF]

Nat Commun
Gundermann DG, Lymer S, Lennon J, Blau J.   +3 more
europepmc   +1 more source

Selection, counterselection, and conditional gene expression for genetic biocontrol of insects

Insect Science, EarlyView.
Selection, counterselection, and conditional expression can be used for sex separation. Selection (S) and counterselection (CS) genes are linked to the sex chromosomes (e.g., the X and Y chromosomes) to confer sex‐specific selection or counterselection based on the presence or absence of the S or CS genes.
Melanie Hempel, Zhijian Tu
wiley   +1 more source

A temperature-sensitive CRISPR-Cas12a system for sterile insect technique. [PDF]

Nat Commun
Nguyen C, Omotayo AI, Sanz Juste S, Feng X, López Del Amo V.   +4 more
europepmc   +1 more source

Hox Gene Variation Drives Morphological Specialization of Humpback Grouper Cromileptes altivelis

Integrative Zoology, EarlyView.
Cromileptes altivelis exhibits a distinctive “sunken head and humpback” morphology, formed through cranial remodeling. Genetic analyses identified unique amino acid variants in Hoxa7a and Hoxa10b, with functional tests confirming their role in enhancing osteoblast activity and driving cranial remodeling.
Xiaoying Cao, Zhaowei Zhong, Lisheng Wu, Quanyin Liu, Shaoxiong Ding   +4 more
wiley   +1 more source

Substantial enhancement of <i>Agrobacterium</i>-mediated transgene-free genome editing via short-term chemical selection using citrus as a model plant. [PDF]

Hortic Res
Li Y, Liu Z, Gmitter FG, Deng Z, Cheng B, Duan H, Li Y.   +6 more
europepmc   +1 more source