Results 31 to 40 of about 355,983 (382)
Pharmacokinetics and tolerance of repeated oral administration of 5-fluorocytosine in healthy dogs
BMC Veterinary Research, 2021 Background 5-fluorocytosine is a pyrimidine and a fluorinated cytosine analog mainly used as an antifungal agent. It is a precursor of 5-fluorouracil, which possesses anticancer properties.
Jérémy Béguin +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Amphioxus is a promising model organism for understanding the origin and evolution of vertebrates due to its basal phylogenetic position among chordates.
Jiaqi Zou +7 more
doaj +1 more source
CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair
Nature Communications, 2018 In genome editing with CRISPR–Cas9, transgene integration often remains challenging. Here, we present an approach for increasing the efficiency of transgene integration by homology-dependent repair (HDR).
M. Charpentier +15 more
semanticscholar +1 more source
Engineering of CRISPR/Cas9‐mediated potyvirus resistance in transgene‐free Arabidopsis plants
Molecular plant pathology, 2016 Summary Members of the eukaryotic translation initiation factor (eIF) gene family, including eIF4E and its paralogue eIF(iso)4E, have previously been identified as recessive resistance alleles against various potyviruses in a range of different hosts ...
D. E. Pyott, Emma Sheehan, A. Molnár
semanticscholar +1 more source
Transgene silencing and transgene-derived siRNA production in tobacco plants homozygous for an introduced AtMYB90 construct [PDF]
, 2015 Transgenic tobacco (Nicotiana tabacum) lines were engineered to ectopically over-express AtMYB90 (PAP2), an R2-R3 Myb gene associated with regulation of anthocyanin production in Arabidopsis thaliana. Independently transformed transgenic lines, Myb27 and
Cakir, Cahid +4 more
core +1 more source
Transgene-design: a web application for the design of mammalian transgenes [PDF]
Bioinformatics, 2022 AbstractSummaryTransgene-design is a web application to help design transgenes for use in mammalian studies. It is predicated on the recent discovery that human intronless transgenes and native retrogenes can be expressed very effectively if the GC content at exonic synonymous sites is high.
Stefanie Mühlhausen, Laurence D Hurst
openaire +2 more sources
Biotechnology & Biotechnological Equipment, 2022 Flowering transition is important in plant growth and development, and the SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1) gene belongs to the MADS-box gene family, which is an integrator involved in the regulation of flower formation in plants.
Xuan Li +4 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2020 Oncolytic virotherapy is a promising therapeutic approach for the treatment of cancer. TG6002 is a recombinant oncolytic vaccinia virus deleted in the thymidine kinase and ribonucleotide reductase genes and armed with the suicide gene FCU1, which encodes
Jérémy Béguin +12 more
doaj +1 more source
GmSTK12 Participates in Salt Stress Resistance in Soybean
Agronomy, 2023 Soybean (Glycine max (Linn.) Merr.) is a widely-cultivated crop, the yield of which is markedly affected by adverse environmental conditions. Soil salinization, in particular, has led to the degradation of agricultural land, resulting in poor plant ...
Yang Liu +8 more
doaj +1 more source
Journal of Andrology, 1997 There are numerous tools available to modify the genetic makeup of animals. They are being used to good advantage for studying basic biological phenomena. Within the decade, biomedical products derived from transgenic animals will be available, but the use of this technology for enhancing the quality and efficiency of livestock production will await ...
Wall, R. J. +4 more
openaire +5 more sources