Pharmacokinetics and tolerance of repeated oral administration of 5-fluorocytosine in healthy dogs
BMC Veterinary Research, 2021 Background 5-fluorocytosine is a pyrimidine and a fluorinated cytosine analog mainly used as an antifungal agent. It is a precursor of 5-fluorouracil, which possesses anticancer properties.
Jérémy Béguin +8 more
doaj +1 more source
Transgene silencing and transgene-derived siRNA production in tobacco plants homozygous for an introduced AtMYB90 construct [PDF]
, 2015 Transgenic tobacco (Nicotiana tabacum) lines were engineered to ectopically over-express AtMYB90 (PAP2), an R2-R3 Myb gene associated with regulation of anthocyanin production in Arabidopsis thaliana. Independently transformed transgenic lines, Myb27 and
Cakir, Cahid +4 more
core +1 more source
Biotechnology & Biotechnological Equipment, 2022 Flowering transition is important in plant growth and development, and the SUPPRESSOR OF OVEREXPRESSION OF CO 1 (SOC1) gene belongs to the MADS-box gene family, which is an integrator involved in the regulation of flower formation in plants.
Xuan Li +4 more
doaj +1 more source
CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair
Nature Communications, 2018 In genome editing with CRISPR–Cas9, transgene integration often remains challenging. Here, we present an approach for increasing the efficiency of transgene integration by homology-dependent repair (HDR).
M. Charpentier +15 more
semanticscholar +1 more source
Frontiers in Genetics, 2022 Cystatin proteins are known to form a superfamily of cysteine protease inhibitors, which play a key role in protein degradation and are related to different physiological processes, such as development and immunity.
Juan Antonio Ramirez Merlano +1 more
doaj +1 more source
Viral proteins expressed in the protozoan parasite Eimeria tenella are detected by the chicken immune system [PDF]
, 2016 BACKGROUND: Eimeria species are parasitic protozoa that cause coccidiosis, an intestinal disease commonly characterised by malabsorption, diarrhoea and haemorrhage that is particularly important in chickens.
Blake, D P +6 more
core +3 more sources
VEZF1 elements mediate protection from DNA methylation [PDF]
, 2010 There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
AC Bell +54 more
core +5 more sources
Frontiers in Cell and Developmental Biology, 2021 Amphioxus is a promising model organism for understanding the origin and evolution of vertebrates due to its basal phylogenetic position among chordates.
Jiaqi Zou +7 more
doaj +1 more source
Enhancement of Recombinant Protein Production in Transgenic Nicotiana benthamiana Plant Cell Suspension Cultures with Co-Cultivation of Agrobacterium Containing Silencing Suppressors. [PDF]
, 2018 We have previously demonstrated that the inducible plant viral vector (CMViva) in transgenic plant cell cultures can significantly improve the productivity of extracellular functional recombinant human alpha-1-antiryspin (rAAT) compared with either a ...
Dandekar, Abhaya M +3 more
core +3 more sources
Engineering of CRISPR/Cas9‐mediated potyvirus resistance in transgene‐free Arabidopsis plants
Molecular plant pathology, 2016 Summary Members of the eukaryotic translation initiation factor (eIF) gene family, including eIF4E and its paralogue eIF(iso)4E, have previously been identified as recessive resistance alleles against various potyviruses in a range of different hosts ...
D. E. Pyott, Emma Sheehan, A. Molnár
semanticscholar +1 more source