Results 31 to 40 of about 227,142 (341)

A meta-analysis of the antiviral activity of the HBV-specific immunotherapeutic TG1050 confirms its value over a wide range of HBsAg levels in a persistent HBV pre-clinical model

open access: yesHuman Vaccines & Immunotherapeutics, 2018
Pre-clinical models mimicking persistent hepatitis B virus (HBV) expression are seldom, do not capture all features of a human chronic infection and due to their complexity, are subject to variability.
Roland Kratzer   +7 more
doaj   +1 more source

Compensation of Wild Plants Weakens the Effects of Crop-Wild Gene Flow on Wild Rice Populations

open access: yesFrontiers in Plant Science, 2021
Crop-wild gene flow may alter the fitness of the recipient i.e., crop-wild hybrids, then potentially impact wild populations, especially for the gene flow carrying selective advantageous crop alleles, such as transgenes conferring insect resistance ...
Dongxin Ouyang   +9 more
doaj   +1 more source

Transgenic Animal Technology

open access: yesJournal of Andrology, 1997
There are numerous tools available to modify the genetic makeup of animals. They are being used to good advantage for studying basic biological phenomena. Within the decade, biomedical products derived from transgenic animals will be available, but the use of this technology for enhancing the quality and efficiency of livestock production will await ...
Wall, R. J.   +4 more
openaire   +5 more sources

GmSTK12 Participates in Salt Stress Resistance in Soybean

open access: yesAgronomy, 2023
Soybean (Glycine max (Linn.) Merr.) is a widely-cultivated crop, the yield of which is markedly affected by adverse environmental conditions. Soil salinization, in particular, has led to the degradation of agricultural land, resulting in poor plant ...
Yang Liu   +8 more
doaj   +1 more source

Transgene Expression in Microalgae—From Tools to Applications

open access: yesFrontiers in Plant Science, 2016
Microalgae comprise a biodiverse group of photosynthetic organisms that reside in water sources and sediments. The green microalgae Chlamydomonas reinhardtii was adopted as a useful model organism for studying various physiological systems.
Lior Doron, Na’ama Segal, M. Shapira
semanticscholar   +1 more source

Mapping Transgene Insertion Sites Reveals Complex Interactions Between Mouse Transgenes and Neighboring Endogenous Genes

open access: yesbioRxiv, 2018
Transgenic mouse lines are routinely employed to label and manipulate distinct cell types. The transgene generally comprises cell-type specific regulatory elements linked to a cDNA encoding a reporter or other proteins.
Mallory A. Laboulaye   +4 more
semanticscholar   +1 more source

Frequent Occurrence of Transgene Deletion in Transgenic Plants

open access: yesMolecules and Cells, 1998
The status of the transgene in tobacco plants transformed by Agrobacterium was analyzed with PCR. Twelve percent of the transgenic plants with the nptII gene showed different levels of transgene deletion, which was also found in transgenic watermelon (10-30%) and carrot (40-60%).
Kim, YS   +4 more
openaire   +2 more sources

The EF‐1α promoter maintains high‐level transgene expression from episomal vectors in transfected CHO‐K1 cells

open access: yesJournal of Cellular and Molecular Medicine, 2017
In our previous study, we demonstrated that episomal vectors based on the characteristic sequence of matrix attachment regions (MARs) and containing the cytomegalovirus (CMV) promoter allow transgenes to be maintained episomally in Chinese hamster ovary (
Xiaoyin Wang   +7 more
semanticscholar   +1 more source

Highly efficient CRISPR/Cas9-mediated transgene knockin at the H11 locus in pigs

open access: yesScientific Reports, 2015
Transgenic pigs play an important role in producing higher quality food in agriculture and improving human health when used as animal models for various human diseases in biomedicine.
Jinxue Ruan   +11 more
semanticscholar   +1 more source

An auxin-inducible, GAL4-compatible, gene expression system for Drosophila

open access: yeseLife, 2022
The ability to control transgene expression, both spatially and temporally, is essential for studying model organisms. In Drosophila, spatial control is primarily provided by the GAL4/UAS system, whilst temporal control relies on a temperature-sensitive ...
Colin D McClure   +8 more
doaj   +1 more source

Home - About - Disclaimer - Privacy