Results 41 to 50 of about 360,625 (378)
Molecular Therapy: Oncolytics, 2020 Oncolytic virotherapy is a promising therapeutic approach for the treatment of cancer. TG6002 is a recombinant oncolytic vaccinia virus deleted in the thymidine kinase and ribonucleotide reductase genes and armed with the suicide gene FCU1, which encodes
Jérémy Béguin +12 more
doaj +1 more source
Compensation of Wild Plants Weakens the Effects of Crop-Wild Gene Flow on Wild Rice Populations
Frontiers in Plant Science, 2021 Crop-wild gene flow may alter the fitness of the recipient i.e., crop-wild hybrids, then potentially impact wild populations, especially for the gene flow carrying selective advantageous crop alleles, such as transgenes conferring insect resistance ...
Dongxin Ouyang +9 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2018 Pre-clinical models mimicking persistent hepatitis B virus (HBV) expression are seldom, do not capture all features of a human chronic infection and due to their complexity, are subject to variability.
Roland Kratzer +7 more
doaj +1 more source
Rescue of splicing-mediated intron loss maximizes expression in lentiviral vectors containing the human ubiquitin C promoter. [PDF]
, 2014 Lentiviral vectors almost universally use heterologous internal promoters to express transgenes. One of the most commonly used promoter fragments is a 1.2-kb sequence from the human ubiquitin C (UBC) gene, encompassing the promoter, some enhancers, first
Cooper, Aaron R +3 more
core +1 more source
bioRxiv, 2018 Transgenic mouse lines are routinely employed to label and manipulate distinct cell types. The transgene generally comprises cell-type specific regulatory elements linked to a cDNA encoding a reporter or other proteins.
Mallory A. Laboulaye +4 more
semanticscholar +1 more source
Genome engineering of stem cells for autonomously regulated, closed-loop delivery of biologic drugs [PDF]
, 2017 Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α).
Brunger, Jonathan M +4 more
core +3 more sources
Journal of Cellular and Molecular Medicine, 2017 In our previous study, we demonstrated that episomal vectors based on the characteristic sequence of matrix attachment regions (MARs) and containing the cytomegalovirus (CMV) promoter allow transgenes to be maintained episomally in Chinese hamster ovary (
Xiaoyin Wang +7 more
semanticscholar +1 more source
Cowpox Virus: A New and Armed Oncolytic Poxvirus
Molecular Therapy: Oncolytics, 2017 Oncolytic virus therapy has recently been recognized as a promising new therapeutic approach for cancer treatment. In this study, we are proposing for the first time to evaluate the in vitro and in vivo oncolytic capacities of the Cowpox virus (CPXV). To
Marine Ricordel +11 more
doaj +1 more source
GmSTK12 Participates in Salt Stress Resistance in Soybean
Agronomy, 2023 Soybean (Glycine max (Linn.) Merr.) is a widely-cultivated crop, the yield of which is markedly affected by adverse environmental conditions. Soil salinization, in particular, has led to the degradation of agricultural land, resulting in poor plant ...
Yang Liu +8 more
doaj +1 more source
Transgene Expression in Microalgae—From Tools to Applications
Frontiers in Plant Science, 2016 Microalgae comprise a biodiverse group of photosynthetic organisms that reside in water sources and sediments. The green microalgae Chlamydomonas reinhardtii was adopted as a useful model organism for studying various physiological systems.
Lior Doron, Na’ama Segal, M. Shapira
semanticscholar +1 more source