Results 111 to 120 of about 53,894 (256)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Passing experiences on to future generations: endocrine disruptors and transgenerational inheritance of epimutations in brain and sperm

Epigenetics, 2018
All animals have body burdens of polychlorinated biphenyls (PCBs) despite their ban decades ago. These and modern endocrine-disrupting chemicals (EDCs) such as the fungicide vinclozolin (VIN) perturb hormone signaling and lead to dysfunctions following ...
Ross Gillette, Min Ji Son, Lexi Ton, Andrea C. Gore, David Crews   +4 more
doaj   +1 more source

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

Biological Reviews, EarlyView.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira   +3 more
wiley   +1 more source

Editorial: Long-term toxicity and epigenetic effects of environmental exposures

Frontiers in Genetics, 2022
Douglas M. Ruden, Kai Wang, Kai Wang, Kangxu Wang, Bambarendage P. U. Perera, Rebekah Lee Petroff   +5 more
doaj   +1 more source

Transgenerational sperm DNA methylation epimutation developmental origins following ancestral vinclozolin exposure

Epigenetics, 2019
A number of environmental factors from nutrition to toxicants have been shown to promote the epigenetic transgenerational inheritance of disease and phenotypic variation. This requires alterations in the germline (sperm or egg) epigenome. Previously, the
Michael K. Skinner, Eric Nilsson, Ingrid Sadler-Riggleman, Daniel Beck, Millissia Ben Maamar, John R. McCarrey   +5 more
doaj   +1 more source

Placing Children in Residential Care: A Scoping Review of Decision‐Making and Matching Criteria

Child &Family Social Work, EarlyView.
ABSTRACT Placement decisions in residential care (RC) represent one of the most challenging aspects of child protection services. While often framed as a last‐resort solution, RC aims to serve children whose needs are not met through family‐based interventions and is used differently across countries.
Chiara Monti
wiley   +1 more source

Reduced fecundity associated with Wolbachia infection in a Neotropical drosophilid Redução da fecundidade associada à infecção por Wolbachia em um drosofilídeo Neotropical

Ecological Entomology, EarlyView.
Using multiple infected and uninfected Drosophila sturtevanti lines, we investigated (i) the impact of Wolbachia on fecundity and (ii) its effects relative to antibiotic treatment. Based on over 1680 dissected ovaries, fecundity was similar between infected and uninfected flies.
Letícia Carlesso de Paula Sena, Marina Magalhães Moreira, Luísa de Paula Bouzada Dias, Jhonny José Magalhães Guedes, Karla Suemy Clemente Yotoko   +4 more
wiley   +1 more source

Exposure to the Oestrogenic Pollutant 17α‐Ethinyl Estradiol (EE2) Does Not Alter the Behaviour of a Coastal Marine Fish, Cristiceps australis

Ethology, EarlyView.
Environmental contamination with the synthetic estrogen 17α‐ethinyl estradiol (EE2) is widespread in coastal ecosystems, yet behavioural effects in marine fishes remain poorly understood. We exposed southern crested weedfish (Cristiceps australis) to low and high EE2 concentrations for 14 days and assessed boldness and anxiety using a refuge‐use assay.
Shiho Ozeki, Rhiannon V. Eastment, Jack L. Manera, Raiko Rafeeq, Anne Peters, Jake M. Martin, Bob B. M. Wong   +6 more
wiley   +1 more source

Posterity or Prosperity? Critiquing and Refiguring Prosperity Theologies in an Ecological Age

, 2015
At the beginning of the twenty-first century, prosperity theologies have simultaneously received a warm reception by some and a critical cold shoulder by others.
Swoboda, A.J.
core   +1 more source

Intergenerational Trauma in Refugee Families: A Scoping Review of Contextual and Systemic Perspectives

Journal of Family Theory &Review, EarlyView.
ABSTRACT This scoping review analyzed 18 current research articles to identify how scholars conceptualize and use theory to understand trauma transmission in refugee family systems. Analysis of theory and results across this body of literature resulted in several significant findings.
Zamzam Dini, Kadija Mussa
wiley   +1 more source