Results 61 to 70 of about 53,894 (256)

Sulfonate-Modified Polystyrene Nanoparticle at Precited Environmental Concentrations Induces Transgenerational Toxicity Associated with Increase in Germline Notch Signal of Caenorhabditis elegans

Toxics, 2023
Recently, the transgenerational toxicity of nanoplastics has received increasing attention. Caenorhabditis elegans is a useful model to assess the transgenerational toxicity of different pollutants. In nematodes, the possibility of early-life exposure to
Wenmiao He, Aihua Gu, Dayong Wang
doaj   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

The Silent Voice of Those Who are no Longer: Transgenerational Transmission of Information from the Perspective of the Informational Model of Consciousness [PDF]

, 2019
The “nature or nurture” problem concerning the debate on the innate features with respect to the acquired ones is approached in terms of information, from the perspective of the Informational Model of Consciousness.
Gaiseanu, Florin
core   +1 more source

Pre-reproductive parental enriching experiences influence progeny’s developmental trajectories [PDF]

, 2018
While the positive effects of environmental enrichment (EE) applied after weaning, in adulthood, during aging, or even in the presence of brain damage have been widely described, the transgenerational effects of pre-reproductive EE have been less ...
Berretta, Erica, Caporali, Paola, Cutuli, Debora, Gelfo, Francesca, Laricchiuta, Daniela, Petrosini, Laura   +5 more
core   +1 more source

Transgenerational mutation by radiation [PDF]

Nature, 2000
Parental exposure to ionizing radiation increases the frequency of germline mutations detectable in the next generation1. Parental exposure can also increase the rate of mutation in somatic cells2,3 and confer a predisposition to cancer4,5,6 in offspring, suggesting that there could be an indirect effect of radiation on somatic genome stability that is
Dubrova, YE, Plumb, M, Gutierrez, B, Boulton, E, Jeffreys, AJ   +4 more
openaire   +3 more sources

Projected Warming of the Southern Ocean Disrupts Embryonic Development and Hatch Timing in Antarctic Fish

Global Change Biology Communications, EarlyView.
Embryos are particularly sensitive to thermal challenge. Antarctic fish embryos raised at projected Southern Ocean temperatures hatch during the winter, have a high incidence of morphological abnormalities, have shorter body lengths, and express genes indicative of cellular stress.
Margaret Streeter, Nathalie R. Le François, Thomas Desvignes, Jacob Grondin, John H. Postlethwait, H. William Detrich III, Jacob M. Daane   +6 more
wiley   +1 more source

Reported transgenerational responses to Pseudomonas aeruginosa in Caenorhabditis elegans are not robust

eLife
We report our attempt to replicate reports of transgenerational epigenetic inheritance in Caenorhabditis elegans. Multiple laboratories report that C.
Daniel Patrick Gainey, Andrey V Shubin, Craig P Hunter   +2 more
doaj   +1 more source

Grandmother's pregnancy complications and autism spectrum disorders in grandchildren, a California multigenerational cohort study

JCPP Advances, EarlyView.
Abstract Background Pregnancy complications have been associated with offspring autism spectrum disorders (ASD). There has also been increasing evidence for multigenerational risk factors of ASD. Methods In a multigenerational California birth cohort of 1,740,379 mother–child pairs, we investigated pregnancy complications when the grandmother was ...
Ting Chow, Qi Meng, Jingyuan Xiao, Karl O’Sharkey, Zeyan Liew, Beate Ritz   +5 more
wiley   +1 more source

Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral origins of polycystic ovarian syndrome and primary ovarian insufficiency

Epigenetics, 2018
Two of the most prevalent ovarian diseases affecting women’s fertility and health are Primary Ovarian Insufficiency (POI) and Polycystic Ovarian Syndrome (PCOS). Previous studies have shown that exposure to a number of environmental toxicants can promote
Eric Nilsson, Rachel Klukovich, Ingrid Sadler-Riggleman, Daniel Beck, Yeming Xie, Wei Yan, Michael K. Skinner   +6 more
doaj   +1 more source

Investigating Possible Trans/Intergenerational Associations With Obesity in Young Adults Using an Exposome Approach

Frontiers in Genetics, 2019
Animal experiments demonstrate ways in which an exposure in one generation can be reflected in a variety of outcomes in later generations. In parallel human observational studies have shown associations between grandparental and parental exposures to ...
Jean Golding, Steven Gregory, Kate Northstone, Yasmin Iles-Caven, Genette Ellis, Marcus Pembrey   +5 more
doaj   +1 more source