The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. [PDF]
, 1996 Thymocytes must bind major histocompatibility complex (MHC) proteins on thymic epithelial cells in order to mature into either CD8+ cytotoxic T cells or CD4+ helper T cells.
Corbella, P +5 more
core
Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages
Advanced Science, EarlyView.Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu +14 more
wiley +1 more source
CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice.
PLoS ONE, 2014 CTRP2 is a secreted plasma protein of the C1q family that enhances glycogen deposition and fat oxidation in cultured myotubes. Its in vivo metabolic function, however, has not been established.
Jonathan M Peterson +3 more
doaj +1 more source
Interleukin-12 inhibits hepatitis B virus replication in transgenic mice [PDF]
, 1997 Victoria J. Cavanaugh +2 more
openalex +1 more source
Advanced Science, EarlyView.Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren +9 more
wiley +1 more source
Interferon-γ Induces Chronic Active Myocarditis and Cardiomyopathy in Transgenic Mice [PDF]
, 2007 Kurt Reifenberg +18 more
openalex +1 more source
Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation
Advanced Science, EarlyView.FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin +14 more
wiley +1 more source
PLoS ONE, 2012 The effects of tau hyperphosphorylation and aggregation on axonal transport were investigated in the optic nerve of mice transgenic for human mutant P301S tau. Transport was examined using cholera toxin B tracing.
Natalie D Bull +4 more
doaj +1 more source
Enforced Expression of GATA-3 During T Cell Development Inhibits Maturation of CD8 Single-Positive Cells and Induces Thymic Lymphoma in Transgenic Mice [PDF]
, 2001 Martijn C. Nawijn +7 more
openalex +1 more source
Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy. [PDF]
, 2019 Many potentially therapeutic molecules have been identified for treating Duchenne muscular dystrophy. However, targeting those molecules only to sites of active pathology is an obstacle to their clinical use.
Bertoni, Carmen +6 more
core