Results 131 to 140 of about 3,746,688 (357)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

What Threshold of Amyloid Reduction Is Necessary to Meaningfully Improve Cognitive Function in Transgenic Alzheimer’s Disease Mice?

Journal of Alzheimer's Disease Reports
Background: Amyloid-β plaques (Aβ) are associated with Alzheimer’s disease (AD). Pooled assessment of amyloid reduction in transgenic AD mice is critical for expediting anti-amyloid AD therapeutic research.
Anita Singh, Matthew Maker, Jayant Prakash, Raghav Tandon, Cassie S. Mitchell   +4 more
doaj   +1 more source

CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice.

PLoS ONE, 2014
CTRP2 is a secreted plasma protein of the C1q family that enhances glycogen deposition and fat oxidation in cultured myotubes. Its in vivo metabolic function, however, has not been established.
Jonathan M Peterson, Marcus M Seldin, Stefanie Y Tan, G William Wong   +3 more
doaj   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Neural stem cell biology and neurogenesis in mouse models of aging and Alzheimer's disease [PDF]

, 2006
The etiology of Alzheimer’s disease (AD) remains a great challenge for neurological research. Extensive investigations for almost one hundred years have led to profound insights of the pathological and molecular mechanisms that affect the AD brain, and
Ermini, Florian V.
core   +1 more source

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

Nature, 2020
L. Bao, Wei Deng, Baoying Huang, Hong Gao, Jiangning Liu, L. Ren, Q. Wei, Pin Yu, Yanfeng Xu, Feifei Qi, Yajin Qu, Feng-di Li, Qi Lv, Wenling Wang, Jing Xue, Shuran Gong, Mingya Liu, Guanpeng Wang, Shunyi Wang, Zhiqi Song, Linna Zhao, Peipei Liu, Li Zhao, F. Ye, Huijuan Wang, Wei-min Zhou, N. Zhu, Wei Zhen, Haisheng Yu, Xiaojuan Zhang, Li Guo, Lan Chen, Conghui Wang, Ying Wang, Xinming Wang, Yan Xiao, Qiangming Sun, Hongqi Liu, F. Zhu, Chun-peng Ma, Lingmei Yan, Mengli Yang, Jun Han, Wenbo Xu, W. Tan, Xiaozhong Peng, Q. Jin, Guizhen Wu, Chuan Qin   +48 more
semanticscholar   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Social disruption stress exacerbates alpha-galactosylceramide-induced hepatitis in mice

, 2005
Objective: Psychosocial stress has been suggested as a possible aggravating factor in liver diseases, however, the underlying mechanism has yet to be clarified.
Chida, Y, Kubo, C, Sonoda, J, Sudo, N
core  

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice

, 2010
BACKGROUND: Parkinson's disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA). PD is characterized pathologically
Liss Birgit, Paolo Calabresi, Auburger Georg, Silke Nuber, Javier Fernández-Ruiz, Lastres-Becker, Isabel, Double Kay L., Auburger, Georg, Lüddens Hartmut, Nuber Silke, Fernández-Ruiz, Javier, Fernández-Ruiz Javier, Gispert, Suzana, Schlaudraff Falk, Nuber, Silke, García-Arencibia Moisés, García-Arencibia, Moisés, Manfred Gerlach, Gerlach, Manfred, Double, Kay L., Kay L. Double, Alexander Kurz, Tantucci Michela, Bonin Michael, Bockhart, Vanessa, Gispert Suzana, Calabresi, Paolo, Lüddens, Hartmut, Moisés García-Arencibia, Tozzi Alessandro, Michael Bonin, Michela Tantucci, Schlaudraff, Falk, Hartmut Lüddens, Lastres-Becker Isabel, Isabel Lastres-Becker, Tantucci, Michela, Birgit Liss, Wüllner Ullrich, Ullrich Wüllner, Kurz Alexander, Vanessa Bockhart, Liss, Birgit, Falk Schlaudraff, Kurz, Alexander, Suzana Gispert, Bonin, Michael, Calabresi Paolo, Wüllner, Ullrich, Georg Auburger, Tozzi, Alessandro, Kay L Double, Alessandro Tozzi, Gerlach Manfred, Bockhart Vanessa   +54 more
core   +1 more source