Results 201 to 210 of about 3,709,047 (395)

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Establishment an echovirus 6 infection model based on hFcRn transgenic mice. [PDF]

Front Med (Lausanne)
Li F, Fu Y, Huang L, Zhang H, Huang J, Wang Y, Xie Z, Chen X.   +7 more
europepmc   +1 more source

B cells are important as antigen presenting cells for induction of MHC-restricted arthritis in transgenic mice

, 2007
Veena Taneja, Christopher J. Krco, Marshall D. Behrens, Harvinder S. Luthra, Marie Griffiths, Chella S. David   +5 more
openalex   +1 more source

Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice [PDF]

, 2018
Wenjuan Yang, Keyan Zhou, Yue Zhou, Yuqian An, T. Hu, Jing Lü, Shichao Huang, Gang Pei   +7 more
openalex   +1 more source

Behavior‐ and Cell Type‐Specific Cortico‐Striatal Decoupling in a Parkinson's Disease‐Like Mouse Model

Advanced Science, EarlyView.
Utilizing dual‐site fiber photometry, this study examines cortico‐striatal coupling with cell type resolution, identifying behavior‐ and cell type‐specific cortico striatal decoupling and its dopamine‐dependent mechanism in a Parkinson's disease mouse model.
Xu‐Ran Yao, Yang Liu, Wei‐Tong Zheng, Mao‐Qing Huang, Kai‐Wen He   +4 more
wiley   +1 more source

Retraction: Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer's disease. [PDF]

Oncotarget
Braidy N, Essa MM, Poljak A, Selvaraju S, Al-Adawi S, Manivasagm T, Thenmozhi AJ, Ooi L, Sachdev P, Guillemin GJ.   +9 more
europepmc   +1 more source

Potentiation of Excitotoxicity in Transgenic Mice Overexpressing Neuronal Cyclooxygenase-2

, 1999
Kevin A. Kelley, Lap Ho, David Winger, José Freire-Moar, Cy Blanco Borelli, Paul Aisen, Giulio Maria Pasinetti   +6 more
openalex   +2 more sources

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

Establishment of disseminated neonatal echovirus 11 infection model in hFcRn transgenic mice. [PDF]

Virol J
Li F, Li Q, Zhao X, Fu Y, Zhang L, Chen X, Xie Z.   +6 more
europepmc   +1 more source

Correlative dynamic contrast MRI and microscopic assessments of tumor vascularity in RIP‐tag2 transgenic mice [PDF]

, 2009
Barbara Sennino, Hans‐Juergen Raatschen, Michael F. Wendland, Yanjun Fu, Weon‐Kyoo You, David M. Shames, Donald M. McDonald, Robert C. Brasch   +7 more
openalex   +1 more source