Results 201 to 210 of about 1,712,319 (264)
Retraction Note: Glimepiride mitigates tauopathy and neuroinflammation in P301S transgenic mice: role of AKT/GSK3β signaling. [PDF]
InflammopharmacologyZaki MO +4 more
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GluN2B-specific NMDAR positive allosteric modulation reverses cognitive and behavioral abnormalities in <i>Mecp2</i> and <i>Disc1</i> transgenic mice. [PDF]
Sci AdvGe Y +12 more
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Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. [PDF]
BMC NeurosciSpencer B +9 more
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Hypomorphic Protein Expression of DNA Polymerase Beta in Polβ<sup>L301R-V303R/L301R-V303R</sup> Knock-In Transgenic Mice Does Not Impact Global DNA Methylation Levels in the Midbrain. [PDF]
BiomoleculesJacobs B +11 more
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Paediatric Respiratory Reviews, 2006
For the past 20 years researchers have used transgenic mice to help understand the basic mechanisms associated with inherited human and animal diseases. The ability to integrate exogenous genetic information into the mouse genome has revolutionised the analysis of gene function.
Judy M, Hickman-Davis, Ian C, Davis
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For the past 20 years researchers have used transgenic mice to help understand the basic mechanisms associated with inherited human and animal diseases. The ability to integrate exogenous genetic information into the mouse genome has revolutionised the analysis of gene function.
Judy M, Hickman-Davis, Ian C, Davis
openaire +3 more sources
Genome, 1989
Stable integration into the mouse genome of exogenous genetic information has become, over the past few years, a very potent approach for different aspects of biology. It is a common feature that the integrated exogenous gene (the transgene) is expressed properly both spatially and temporally.
Babinet, C. +2 more
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Stable integration into the mouse genome of exogenous genetic information has become, over the past few years, a very potent approach for different aspects of biology. It is a common feature that the integrated exogenous gene (the transgene) is expressed properly both spatially and temporally.
Babinet, C. +2 more
openaire +3 more sources
Phototransduction in transgenic mice
Current Opinion in Neurobiology, 1996Transgenic mice provide a powerful tool for elucidating the molecular mechanisms of phototransduction. Mice expressing a phosphorylation-deficient rhodopsin and mice deficient in arrestin are being used to study shutoff of photoactivated rhodopsin. These in vivo mouse studies indicate that shutoff is partially mediated by rhodopsin phosphorylation ...
J, Lem, C L, Makino
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BioEssays, 1987
AbstractTransgenic mice constitute an entirely new dimension of mammalian molecular genetics. They allow us to observe genes at work in the intact organism. Virtually every sector of biomedical research is likely to be affected.
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AbstractTransgenic mice constitute an entirely new dimension of mammalian molecular genetics. They allow us to observe genes at work in the intact organism. Virtually every sector of biomedical research is likely to be affected.
openaire +2 more sources