Results 231 to 240 of about 655,970 (311)

BMP4 regulates asymmetric Pkd2 distribution in mouse nodal immotile cilia and ciliary mechanosensing required for left–right determination

Developmental Dynamics, EarlyView.
Abstract Background Mouse nodal immotile cilia mechanically sense the bending direction for left–right (L–R) determination and activate the left‐side‐specific signaling cascade, leading to increased Nodal activity. Asymmetric distribution of Pkd2, a crucial channel for L–R determination, on immotile cilia has been reported recently. However, the causal
Takanobu A. Katoh, Tim Lange, Yoshiro Nakajima, Kenta Yashiro, Yasushi Okada, Hiroshi Hamada   +5 more
wiley   +1 more source

Retraction Notice: Optimized Turmeric Extract Reduces β-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer's Transgenic Mice. [PDF]

Curr Alzheimer Res
Shytle RD, Tan J, Bickford PC, Rezaizadeh K, Hou L, Zeng J, Sanberg PR, Sanberg CD, Alberte RS, Fink RC, Roschek B.   +10 more
europepmc   +1 more source

Assessing candidate DLX‐regulated genes in the first pharyngeal arch of chick embryos

Developmental Dynamics, EarlyView.
Abstract Background Insights into the development and evolution of asymmetrical jaws will require an understanding of the gene regulatory networks that underpin the differential morphogenesis of the maxillary and mandibular domains of the first pharyngeal arch in a variety of gnathostomes.
Afshan Sohail, Olivia Nicoll, Andrew J. Bendall   +2 more
wiley   +1 more source

Insights into the metastatic bone marrow niche gained from fibronectin and β1 integrin transgenic mice. [PDF]

Neoplasia
Wirth F, Zoeller C, Lubosch A, Schroeder-Braunstein J, Wabnitz G, Nakchbandi IA.   +5 more
europepmc   +1 more source

Protective compunds in animal models of trigeminal activation and neurodegeneration [PDF]

, 2009
Vámos Enikő
core  

A novel transgenic reporter of extracellular acidification in zebrafish elucidates skeletal muscle T‐tubule pH regulation

Developmental Dynamics, EarlyView.
Abstract Disruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to
Leif R. Neitzel, Maya Silver, Aaron H. Wasserman, Samantha Rea, Charles C. Hong, Charles H. Williams   +5 more
wiley   +1 more source

9-Methylfascaplysin Prevents Neuroinflammation and Synaptic Damage via Cell-Specific Inhibition of Kinases in APP/PS1 Transgenic Mice. [PDF]

CNS Neurosci Ther
Le J, Xia C, Xu J, Cai J, Hu C, Bai Y, Chen H, Rong W, Jiang Y, Wu X, Li Y, Wang Q, Naman CB, Wei H, Zhang J, Liu H, Chen X, Liu F, Liang H, Cui W.   +19 more
europepmc   +1 more source

Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing alpha 1(IX) collagen chains with a central deletion.

, 1993
Ken Nakata, Katsuhiko Ono, Jun–ichi Miyazaki, B. R. Olsen, Yasuteru Muragaki, Eijiro Adachi, Kazuhiko Yamamura, Tsukasa Kimura   +7 more
openalex   +1 more source

Activation and inhibition of Notch signaling facilitate proliferative regeneration of sensory cells in adult mice

Eye &ENT Research, EarlyView.
Abstract Due to the limited regenerative capacity in adult mammals, the loss of vestibular hair cells (HCs) leads to balance disorders. In this study, we chronologically reprogrammed adult vestibular supporting cells (SCs) via bimodal regulation of Notch signaling, mimicking dynamic changes in Notch signaling during inner ear development. We found that
Shan Zeng, Tao Jiang, Zhengyi Chen, Huawei Li, Luo Guo, Wenyan Li   +5 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source