Results 271 to 280 of about 3,709,047 (395)

Analysis of differentially expressed genes in early- and late-stage APPsw-transgenic and normal mice using cDNA microarray

, 2007
Seung Jee, Jung Cho, Chuel Kim, Dae Youn Hwang, Sun Bo Shim, Su Seong Lee, Ji Soon Sin, Yang Kim, Jin Young Park, Se Jin Lee, Soo Young Choi, Yong Bae Kim   +11 more
openalex   +2 more sources

A pipeline for the generation of shRNA transgenic mice

Nature Protocols, 2012
L. Dow, P. Premsrirut, J. Zuber, Christof Fellmann, K. McJunkin, C. Miething, Youngkyu Park, R. Dickins, G. Hannon, S. Lowe   +9 more
semanticscholar   +1 more source

AI‐Driven Acceleration of Fluorescence Probe Discovery

Advanced Science, EarlyView.
We present PROBY, an AI model trained on large‐scale datasets to predict key photophysical properties and accelerate the discovery of target‐specific fluorescent probes. By screening a target‐annotated library, PROBY identifies candidate probes for diverse targets and could guide probe optimization, enabling a range of in vitro and in vivo imaging ...
Xuefeng Jiang, Yanbo Li, Xue Tian, Sen Yang, Ruina Luo, Cenxing Zhou, Yuxuan Liu, Jingying Hu, Sen Feng, Lu Gan, Chongzhao Ran, Kun‐Hsing Yu, Junhan Zhao, Xiao Han, Xuan Zhai, Yuntao Jia, Jiapei Dai, Xiyue Wang, Biyue Zhu   +18 more
wiley   +1 more source

Expression of Human Globin Genes in Transgenic Mice Carrying the β‐Globin Gene Cluster with a Mutation Causing ^Gγβ⁺ Hereditary Persistence of Fetal Hemoglobin^a

, 1990
Minoru Tanaka, J. A. Nolan, Ajay Bhargava, Kirsten Lynn Rood, Francis S. Collins, Sherman M. Weissman, Bernard G. Forget, John W. Chamberlain   +7 more
openalex   +2 more sources

Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors.

Cell Structure and Function, 2012
Y. Kamioka, K. Sumiyama, Rei Mizuno, Y. Sakai, E. Hirata, E. Kiyokawa, M. Matsuda   +6 more
semanticscholar   +1 more source

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Correction: High-fat diet activates pyroptosis of retinal pigment epithelial cells in aged TgAPPswePS1 transgenic mice. [PDF]

Eur J Med Res
Cao J, Li J, Zheng H, Dong Z.
europepmc   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Retraction Note: Glimepiride mitigates tauopathy and neuroinflammation in P301S transgenic mice: role of AKT/GSK3β signaling. [PDF]

Inflammopharmacology
Zaki MO, El-Desouky S, Elsherbiny DA, Salama M, Azab SS.   +4 more
europepmc   +1 more source