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, 1995 CD5 is a glycoprotein expressed on all mature T cells [1], a small but distinct subset of B lymphocytes (referred to as Bla cells) [2], some mouse B cell lymphomas and most human chronic lymphocytic leukemias (CLL) [3,4]. Both human and mouse CD5 genes have been cloned.
John F. Kearney +2 more
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Phototransduction in transgenic mice
Current Opinion in Neurobiology, 1996Transgenic mice provide a powerful tool for elucidating the molecular mechanisms of phototransduction. Mice expressing a phosphorylation-deficient rhodopsin and mice deficient in arrestin are being used to study shutoff of photoactivated rhodopsin. These in vivo mouse studies indicate that shutoff is partially mediated by rhodopsin phosphorylation ...
Janis Lem, Clint L. Makino
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BioEssays, 1987
AbstractTransgenic mice constitute an entirely new dimension of mammalian molecular genetics. They allow us to observe genes at work in the intact organism. Virtually every sector of biomedical research is likely to be affected.
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AbstractTransgenic mice constitute an entirely new dimension of mammalian molecular genetics. They allow us to observe genes at work in the intact organism. Virtually every sector of biomedical research is likely to be affected.
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Transgenic Mice and Oncogenesis
Annual Review of Immunology, 1988The creation of transgenic mice carrying specific cancer-promoting genes has opened an exciting new era in oncology. The biological effects of an individual oncogene on diverse cell types can now be assessed directly within the living animal. While transgenic animals bear the introduced oncogene in every tissue, expression of that gene may either be ...
Suzanne Cory, Jerry M. Adams
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Methods, 1996
The ability to direct expression of genes to astrocytes in mice has been one of the major motivators of transcriptional analyses of the glial fibrillary acidic protein (GFAP) gene. Another has been the possibility of discovering signaling pathways that operate during development, disease, and injury-all states that increase GFAP gene activity-by ...
Albee Messing, Michael Brenner
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The ability to direct expression of genes to astrocytes in mice has been one of the major motivators of transcriptional analyses of the glial fibrillary acidic protein (GFAP) gene. Another has been the possibility of discovering signaling pathways that operate during development, disease, and injury-all states that increase GFAP gene activity-by ...
Albee Messing, Michael Brenner
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Oncogenesis of the Lens in Transgenic Mice [PDF]
Science, 1987 Neoplastic tumors of the ocular lens of vertebrates do not naturally occur. Transgenic mice carrying a hybrid gene comprising the murine αA-crystallin promoter (-366 to +46) fused to the coding sequence of the SV40 T antigens developed lens tumors, which obliterated the eye cavity and even invaded neighboring tissue, thus establishing that the lens is ...
Kathleen A. Mahon +5 more
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Molecular Biotechnology, 2001
A "transgenic" mouse is identified by the integration of a foreign DNA into its genome. Such animals serve as experimental systems for the study of gene expression and are often generated as models for human diseases. Direct microinjection of DNA into the male pronucleus of a mouse zygote has been the method most extensively used in the production of ...
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A "transgenic" mouse is identified by the integration of a foreign DNA into its genome. Such animals serve as experimental systems for the study of gene expression and are often generated as models for human diseases. Direct microinjection of DNA into the male pronucleus of a mouse zygote has been the method most extensively used in the production of ...
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Pancreatology, 2001
Pancreatic cancer is a devastating disease with a fatal prognosis due to late diagnosis and resistance to radiation and chemotherapy. The average survival after diagnosis is still 3 to 8 months. In the last few years genetic alterations in cancer-causing genes have been identified in tumors and putative premalignant lesions using microdissection ...
Ulrich Zechner +5 more
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Pancreatic cancer is a devastating disease with a fatal prognosis due to late diagnosis and resistance to radiation and chemotherapy. The average survival after diagnosis is still 3 to 8 months. In the last few years genetic alterations in cancer-causing genes have been identified in tumors and putative premalignant lesions using microdissection ...
Ulrich Zechner +5 more
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Journal of Reproductive Immunology, 1999
We have generated a number of transgenic mice using DNA segments derived from the HLA-G gene. Using these mice we have examined the pattern of expression dictated by HLA-G promoter elements in mice and shown that HLA-G functions both as a restriction element and a transplantation antigen recognized by murine T cells.
David H. Munn +3 more
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We have generated a number of transgenic mice using DNA segments derived from the HLA-G gene. Using these mice we have examined the pattern of expression dictated by HLA-G promoter elements in mice and shown that HLA-G functions both as a restriction element and a transplantation antigen recognized by murine T cells.
David H. Munn +3 more
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Cryopreservation of transgenic mice
Genetic Analysis: Biomolecular Engineering, 1991Advances in cryopreservation enable one to freeze embryos without the use of a programmable freezing machine or complex protocols. These methods achieve high rates of survival when mouse embryos are frozen. Understanding the factors that influence the survival of cryopreserved embryos can aid troubleshooting and in adapting freezing strategies from ...
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