Results 291 to 300 of about 655,970 (311)

Insertional mutagenesis in transgenic mice

Transgenic Research, 1994
Increasing numbers of transgenic mouse lines have resulted in several dozens of mutants created by insertional mutagenesis. The advantages of different vector systems and the problems associated with the analysis of mutations and the cloning of the affected genes are discussed in this review.
Ulrich Rüther, Tonnie Rijkers, Astrid Peetz   +2 more
openaire   +3 more sources

Development of btk Transgenic Mice

1995
B cell development is characterized by the orderly expression of cell surface markers and responses to specific activation signals [1]. Tyrosine kinases are involved in signalling pathways that regulate these events [2]. Bruton’s tyrosine kinase (Btk) is a tyrosine kinase expressed in B and myeloid cells [3,4].
E. A. Faust, Owen N. Witte, Douglas C. Saffran, David J. Rawlings   +3 more
openaire   +3 more sources

Transgenic mice

Cell, 1985
R D, Palmiter, R L, Brinster
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Insertional Mutations in Transgenic Mice

1989
Insertional mutagenesis represents a promising approach to the identification of new genes involved in mammalian development. In this paper, we have presented a brief review of the literature on the analysis of mutations caused by DNA and retroviral insertion into the mouse genome.
James J. Lee, Glenn L. Radice, Hyeung Jin Son, William L. Perry, Frank Costantini, Kiran Chada   +5 more
openaire   +3 more sources

Postmortem Examination of Transgenic Mice

2003
Postmortem examination of transgenic animals should ideally be performed by or with the help of a trained pathologist. This is because although the steps in the examination can be manually performed by anyone, the interpretation of the findings can only be done with the knowledge of veterinary medicine.
openaire   +3 more sources

Transgenic mice and the pathogenesis of poliomyelitis

1994
Transgenic mice expressing the cell receptor for poliovirus have been generated and are susceptible to poliovirus infection. TgPVR mice have been used to answer questions about the pathogenesis of poliovirus infection. Despite the widespread pattern of PVR expression, poliovirus infection in TgPVR mice is restricted to only a few sites, indicating that
R. Ren, Vincent R. Racaniello
openaire   +3 more sources

Oncogenesis in Transgenic Mice

1986
The study of the diseases collectively labeled cancer has involved a diverse set of approaches, ranging from clinical evaluation and treatment to tumor induction in experimental organisms, and, perhaps most significantly, into the molecular genetics of cell proliferation and growth control. This book is organized around the remarkable body of knowledge
openaire   +2 more sources

Transgenic RNA Interference in Mice

2008
RNA interference (RNAi) is a powerful tool in deciphering gene function. It has been used extensively, especially in cultured mammalian cells. We have shown that RNAi-induced gene silencing can be generated in mice. With conventional transgenic techniques, shRNA-expressing constructs can be introduced into one-cell mouse embryos. The transgenic animals
openaire   +3 more sources

Histological Examination of Transgenic Mice

2003
Histological examination is important to detect and differentiate among different types of tissue changes at the microscopic level. An enlarged organ can be hyperplastic, hypertrophied, or neoplastic. It can also be merely inflamed or infected. Only a histological examination can differentiate among the various growth disturbances and pathological ...
openaire   +2 more sources

Oncogenes in transgenic mice

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1988
Patricia Baldacci, Rudolf Jaenisch, Sally J. Compere   +2 more
openaire   +3 more sources