Results 231 to 240 of about 2,621,599 (302)

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

A New Targeted Transgenic Mouse Line for the Study of Protocadherin γC4. [PDF]

Genesis
McLeod CM, Hanes CM, Fuller LC, Bhandari S, Lanthier HG, Burgess RW, Weiner JA, Garrett AM.   +7 more
europepmc   +1 more source

Dnmt3a Mutations Limit Normal and Autoreactive CD4+ T Follicular Helper Responses and Attenuate T Cell–Driven Joint Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased markers of inflammation. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

Modeling tumor relapse using proliferation tracing and ablation transgenic mouse. [PDF]

NPJ Breast Cancer
Zhao C, Zheng XN, Huang HY, Tian L.
europepmc   +1 more source

Genetic and population analyses implicate thyroid‐related regulation of RNF144B in chondrocalcinosis

Arthritis &Rheumatology, Accepted Article.
Objectives Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5–15% of the general population and has recently been identified as an osteoarthritis risk factor. However, Its biological pathways remain unclear.
Yahong Wu, Yanning Xu, Paul C. Okoro, Sirine Saafi, Jard de Vries, Xiaoyi Qi, Edwin H.G. Oei, Sita Bierma‐Zeinstra, Trudy Voortman, David Felson, Joyce BJ van Meurs, Layal Chaker, J. Mark Wilkinson, Michelle S. Yau, Jessica Bertrand, Cindy G. Boer   +15 more
wiley   +1 more source

<i>In vivo</i> 3D imaging of ovarian cancer outgrowth in transgenic mouse model with optical coherence tomography. [PDF]

J Biomed Opt
Han H, Mukhamedjanova A, Connolly DC, Iwanicki MP, Wang S.   +4 more
europepmc   +1 more source

Salivary gland transcriptomic analysis and immunophenotyping in the IL-14α transgenic mouse model of Sjögren's disease. [PDF]

Front Dent Med
Woods LT, Jasmer KJ, Muñoz Forti K, Kearns A, Weisman GA.   +4 more
europepmc   +1 more source

Generation of a Transgenic Mouse Model for Investigating Mitochondria in Sperm. [PDF]

Cells
Sarkar H, Batta SR, Wadhwa N, Majumdar SS, Pradhan BS.   +4 more
europepmc   +1 more source

Absence of Microglial Activation and Maintained Hippocampal Neurogenesis in a Transgenic Mouse Model of Crohn's Disease. [PDF]

Cells
Masanetz RK, Mundlos H, Stolzer I, Winkler J, Günther C, Süß P.   +5 more
europepmc   +1 more source