Results 251 to 260 of about 2,621,599 (302)
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A Transgenic Mouse Model of Poliomyelitis
2016Transgenic mice (tg mice) that express the human poliovirus receptor (PVR), CD155, are susceptible to poliovirus and develop a neurological disease that resembles human poliomyelitis. Assessment of the neurovirulence levels of poliovirus strains, including mutant viruses produced by reverse genetics, circulating vaccine-derived poliovirus, and vaccine ...
Satoshi, Koike, Noriyo, Nagata
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Transgenic RNAi Applications in the Mouse
2010Within the past 10 years, RNA interference has emerged as a powerful experimental tool as it allows rapid gene function analysis. Unique features such as reversibility of gene silencing and simultaneous targeting of several genes characterize the approach. In this chapter, transgenic RNAi techniques in reverse mouse genetics are discussed and protocols
Seibler, Jost (Prof. Dr.) +1 more
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An Overview of Transgenic Mouse Production
2003Three basic techniques have emerged for making transgenic mice: two of these, retroviral infection of preimplantation embryos and the manipulation of embryonal stem cells, have attributes which make them desirable in some experiments, but the third technique, microinjection, is by far the most efficient and popular.
D, Murphy, D A, Carter
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Transgenic Myth to Transgenic Mouse
1993Abstract The last few years I’ve been watching with ever more interest the research on genetic engineering that produces transgenic life-forms. Transgenic forms are the fascinating creations that result from mixing genetic material between different species.
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Autopsy and Histological Analysis of the Transgenic Mouse
2003Over the past decades, transgenic and knock-out mouse models have become common use in research laboratories. Detailed phenotypic characterization of such models is essential for understanding basic mechanisms of normal physiology and disease. Hereto, pathological examination is a very helpful tool. This chapter describes detailed procedures to perform
Gijbels, Marion J. J. +1 more
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Transgenic Mouse Colony Management
Current Protocols in Molecular Biology, 2005AbstractThis unit describes strategies and methods used to establish a colony of transgenic mice. Basic mating and genotyping strategies are introduced.
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Transgenic Mouse Models of CMT1A and HNPP
Annals of the New York Academy of Sciences, 1999ABSTRACT: We have generated several PMP22 animal mutants with altered PMP22 gene dosage. A moderate increase in the number of PMP22 genes led to hypomyelination comparable to CMT1A, whereas high copy numbers of transgenic PMP22 resulted in phenotypes resembling more severe forms of hereditary motor and sensory neuropathies.
Suter, U., Nave, K.
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The Rip1Tag2 Transgenic Mouse Model
2016The Rip1Tag2 transgenic mouse model of β-cell carcinogenesis has been instrumental in studying various aspects of tumor angiogenesis and in investigating the response to anti-angiogenic therapeutics. Thereby, the in-depth assessment of blood and lymphatic vessel phenotypes and functionality represents key experimental analyses.
Bill, Ruben, Christofori, Gerhard
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Transgenic Mouse Models of Prion Diseases
The Biomedical & Life Sciences Collection, 2008Prions represent a new biological paradigm of protein-mediated information transfer. In mammals, prions are the cause of fatal, transmissible neurodegenerative diseases, often referred to as transmissible spongiform encephalopathies. Many unresolved issues remain, including the exact molecular nature of the prion, the detailed mechanism of prion ...
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Inducible Transgenic Mouse Models
2010Inducible transgenic mouse models allow for the activation of genes in specific cells and tissues at specific times. Expression levels are dependent on the dose of the agent administered. Effective experimental models are characterized by low background levels of the regulated gene and induction to high levels with sub-physiological levels of inducing ...
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