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The Rip1Tag2 Transgenic Mouse Model
2016The Rip1Tag2 transgenic mouse model of β-cell carcinogenesis has been instrumental in studying various aspects of tumor angiogenesis and in investigating the response to anti-angiogenic therapeutics. Thereby, the in-depth assessment of blood and lymphatic vessel phenotypes and functionality represents key experimental analyses.
Bill, Ruben, Christofori, Gerhard
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Inducible Transgenic Mouse Models
2010Inducible transgenic mouse models allow for the activation of genes in specific cells and tissues at specific times. Expression levels are dependent on the dose of the agent administered. Effective experimental models are characterized by low background levels of the regulated gene and induction to high levels with sub-physiological levels of inducing ...
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Transgenic mouse models of Alzheimer's disease
Physiology & Behavior, 2001Alzheimer's disease (AD) is a neurodegenerative disorder, characterized by a progressive loss of cognitive function. Despite considerable progress, a complete description of the molecular pathology of this disease has yet to be elucidated. In this respect, the need for an animal model that develops some or all aspects of this uniquely human disease in ...
C, Janus, D, Westaway
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Transgenic Mouse Model of Stunned Myocardium
Science, 2000Stunned myocardium is a syndrome of reversible contractile failure that frequently complicates coronary artery disease. Cardiac excitation is uncoupled from contraction at the level of the myofilaments. Selective proteolysis of the thin filament protein troponin I has been correlated with stunned myocardium.
A M, Murphy +6 more
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Transgenic Mouse Models of Prion Diseases
The Biomedical & Life Sciences Collection, 2008Prions represent a new biological paradigm of protein-mediated information transfer. In mammals, prions are the cause of fatal, transmissible neurodegenerative diseases, often referred to as transmissible spongiform encephalopathies. Many unresolved issues remain, including the exact molecular nature of the prion, the detailed mechanism of prion ...
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Transgenic mouse models of breast cancer
Breast Cancer Research and Treatment, 1996Although valuable initial information can be gathered about transformation from in vitro studies, human cancer occurs in the context of a complex interaction with its environment and must ultimately be studied in living animals. Transgenic animal models have been used to study breast transformation for a number of years and have yielded valuable ...
L T, Amundadottir +2 more
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CELLULAR CARDIOMYOPLASTY IN A TRANSGENIC MOUSE MODEL
Transplantation, 2002Recent progress in the cardiotypic differentiation of embryonic and somatic stem cells opens novel prospects for the treatment of cardiovascular disorders. The aim of the present study was to develop a novel surgical approach that allows standardized cellular cardiomyoplasty in mouse with low-perioperative mortality.Reproducible transmural lesions were
Wilhelm, Roell +12 more
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1986
This chapter discusses the preparation of the transgenic mouse. Transgenic mice are generated by the introduction of a cloned piece of DNA into a fertilized mouse egg, with subsequent growth of the embryo to birth and beyond. This method allows the function of specific genes and regulatory elements to be examined in the context of the whole animal with
Leonard G. Davis +2 more
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This chapter discusses the preparation of the transgenic mouse. Transgenic mice are generated by the introduction of a cloned piece of DNA into a fertilized mouse egg, with subsequent growth of the embryo to birth and beyond. This method allows the function of specific genes and regulatory elements to be examined in the context of the whole animal with
Leonard G. Davis +2 more
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Mouse Genetics and Transgenics
1999Abstract A unique book that integrates knowledge from a wide range of expertise, specifically applied to the mouse, and addressed at a wide audience from those new to the field to experts who want an update on the state of the art. Mouse Genetics and Transgenics covers all aspects of using the mouse as a genetic model organism: care ...
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Strategies for Behaviorally Phenotyping the Transgenic Mouse
2019The techniques and protocols to modify the mouse genome described in this volume allow researchers to produce genetic models of a remarkable number and breadth of human disease. The generation of gene-modified mice offers profoundly powerful approaches for bringing known or purported human gene disruptions into mouse models, but the degree to which the
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