Results 171 to 180 of about 3,961,294 (191)

Mutagen-induced somatic mutation rate in primary mammalian cells in relation to maximum life span. [PDF]

Geromedicine
Heid J, Sun S, Ablaeva J, Lee M, Zhang Z, Gorbunova V, Seluanov A, Maslov AY, Vijg J.   +8 more
europepmc   +1 more source

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Transgenic Rodent Gene Mutation Assay in Somatic Tissues

Methods in Pharmacology and Toxicology, 2014
Francesco Marchetti, George R Douglas, Christine L Lemieux   +2 more
exaly   +2 more sources

Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2018
The Organisation for Economic Co-operation and Development Test Guideline 488 (TG 488) provides recommendations for assessing germ cell and somatic cell mutagenicity using transgenic rodent (TGR) models. However, important data gaps exist for selecting an optimal approach for simultaneously evaluating mutagenicity in both cell types.
Roger W L Godschalk, Carole Yauk, Jan van Benthem   +2 more
exaly   +5 more sources

Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays

2011
exaly   +2 more sources

Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review

Environmental and Molecular Mutagenesis, 2022
Jason M. O'Brien, Robert R Young, Carole Yauk   +2 more
exaly  

Comparison of the transgenic rodent mutation assay, error corrected next generation duplex sequencing, and the alkaline comet assay to detect dose-related mutations following exposure to -nitrosodiethylamine

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2023
Patricia A Escobar, Maik Schuler, Phu Van   +2 more
exaly  

Evaluation of the sensitivity and specificity of erythrocyte micronucleus and transgenic rodent gene mutation tests to detect rodent carcinogens

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2016
Masamitsu Honma, Shuichi Hamada, Kenichi Masumura   +2 more
exaly  

Detection of induced male germline mutation: Correlations and comparisons between traditional germline mutation assays, transgenic rodent assays and expanded simple tandem repeat instability assays

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2006
Carole Yauk, George R Douglas, Timothy M Singer   +2 more
exaly  

Spontaneous Mutagenesis in Rodents: Spontaneous Gene Mutations Identified by Neutral Reporter Genes in gpt Delta Transgenic Mice and Rats

Journal of Health Science, 2009
Kenichi Masumura, Takehiko Nohmi
exaly