Results 1 to 10 of about 260 (125)

In vivo mutagenicity assessment of styrene in MutaMouse liver and lung [PDF]

Genes and Environment, 2023
Background Styrene (CAS 100-42-5) is widely used as polystyrene and acrylonitrile–butadiene–styrene resin such as plastic, rubber, and paint. One of the primary uses of styrene is food utensils and containers, but a small amount of styrene transferred ...
Yasumasa Murata, Masakatsu Natsume, Takako Iso, Yoshiyuki Shigeta, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura, Akihiko Hirose, Mariko Matsumoto   +10 more
doaj   +4 more sources

In vivo mutagenicity assessment of orally treated tert-butyl hydroperoxide in the liver and glandular stomach of MutaMouse [PDF]

Genes and Environment, 2023
Background tert-Butyl hydroperoxide (TBHP; CAS 75–91-2), a hydroperoxide, is mainly used as a polymerization initiator to produce polyethylene, polyvinyl chloride, and unsaturated polyester.
Yasumasa Murata, Kenichiro Suzuki, Yoshiyuki Shigeta, Takako Iso, Nozomu Hirose, Takaaki Umano, Katsuyoshi Horibata, Kei-ichi Sugiyama, Akihiko Hirose, Kenichi Masumura, Mariko Matsumoto   +10 more
doaj   +4 more sources

Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations [PDF]

BMC Genomics, 2022
Exposure to environmental mutagens increases the risk of cancer and genetic disorders. We used Duplex Sequencing (DS), a high-accuracy error-corrected sequencing technology, to analyze mutation induction across twenty 2.4 kb intergenic and genic targets ...
Danielle P. M. LeBlanc, Matthew Meier, Fang Yin Lo, Elizabeth Schmidt, Charles Valentine, Andrew Williams, Jesse J. Salk, Carole L. Yauk, Francesco Marchetti   +8 more
doaj   +3 more sources

The development and prevalidation of an in vitro mutagenicity assay based on MutaMouse primary hepatocytes, Part II: Assay performance for the identification of mutagenic chemicals [PDF]

Environmental and Molecular Mutagenesis, 2019
As demonstrated in Part I, cultured MutaMouse primary hepatocytes (PHs) are suitable cells for use in anin vitrogene mutation assay due to their metabolic competence, their “normal” phenotype, and the presence of the MutaMouse transgene for reliable mutation scoring.
Paul White, Mirjam Luijten, Edwin P Zwart   +2 more
exaly   +8 more sources

Increased mutagenicity in the liver of MutaMouse females following oral treatment with commercial-grade toluene diisocyanate [PDF]

Genes and Environment
Background Toluene diisocyanates (TDIs) are high-production-volume chemicals widely used in polyurethane manufacturing. A typical commercial-grade TDI (TDI; 2,4-toluene diisocyanate: 2,6-toluene diisocyanate; 80:20), CAS: 26471-62-5, is mutagenic in ...
Mariko Matsumoto, Masakatsu Natsume, Takako Iso, Takaaki Umano, Yasumasa Murata, Kenichi Masumura, Katsuyoshi Horibata, Kei-ichi Sugiyama   +7 more
doaj   +4 more sources

The development and prevalidation of an in vitro mutagenicity assay based on MutaMouse primary hepatocytes, Part I: Isolation, structural, genetic, and biochemical characterization [PDF]

Environmental and Molecular Mutagenesis, 2019
To develop an improved in vitro mammalian cell gene mutation assay, it is imperative to address the known deficiencies associated with existing assays. Primary hepatocytes isolated from the MutaMouse are ideal for an in vitro gene mutation assay due to their metabolic competence, their “normal” karyotype (i.e., neither transformed nor immortalized ...
Paul White, Mirjam Luijten, Edwin P Zwart   +2 more
exaly   +8 more sources

Whole Genome Sequencing of the Mutamouse Model Reveals Strain- and Colony-Level Variation, and Genomic Features of the Transgene Integration Site [PDF]

Scientific Reports, 2019
AbstractThe MutaMouse transgenic rodent model is widely used for assessing in vivo mutagenicity. Here, we report the characterization of MutaMouse’s whole genome sequence and its genetic variants compared to the C57BL/6 reference genome. High coverage (>50X) next-generation sequencing (NGS) of whole genomes from multiple MutaMouse animals from the ...
Matthew J Meier, Carole Yauk, Francesco Marchetti   +2 more
exaly   +5 more sources

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept^®, Roche): overview [PDF]

AIDS Research and Therapy, 2009
Roche's protease inhibitor nelfinavir mesylate (Viracept®) produced between March 2007-June 2007 was found to contain elevated levels of ethyl methanesulfonate (EMS), a known mutagen (alkylator) – leading to a global recall of the drug.
Jones Judith K, Salgo Miklos, Müller Lutz, Pozniak Anton, Larson Peter, Tweats David   +5 more
doaj   +2 more sources

Prolonged benzo[

Environment International
Chronic exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with increased risk of cancer through a mutagenic mode of action. We investigated how exposure duration influences mutagenicity in bone marrow (BM) and liver of MutaMouse males ...
D.M. Schuster, D.P.M. LeBlanc, G. Zhou, M.J. Meier, A.E. Dodge, P.A. White, A. Zeller, A. Williams, D.C. Eickmeyer, S. Kehm, J. Funk, F. Marchetti, C.L. Yauk   +12 more
doaj   +1 more source

Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review. [PDF]

Environ Mol Mutagen, 2022
Douglas GR, Beevers C, Gollapudi B, Keig-Shevlin Z, Kirkland D, O'Brien JM, van Benthem J, Yauk CL, Young RR, Marchetti F.   +9 more
europepmc   +1 more source