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Enhancing quality and climate resilient traits in vegetatively propagated polyploids: transgenic and genome editing advancements, challenges and future directions [PDF]

open access: yesFrontiers in Genetics
Vegetatively propagated polyploid crops such as potato, strawberry, sugarcane, and banana play a crucial role in global agriculture by meeting essential nutritional and food demands.
Surya Krishna Sakthivel   +2 more
doaj   +2 more sources

Genetic Transformation of Artemisia carvifolia Buch with rol Genes Enhances Artemisinin Accumulation. [PDF]

open access: yesPLoS ONE, 2015
The potent antimalarial drug artemisinin has a high cost, since its only viable source to date is Artemisia annua (0.01-0.8% DW). There is therefore an urgent need to design new strategies to increase its production or to find alternative sources. In the
Erum Dilshad   +4 more
doaj   +3 more sources

Deficiency of Perry syndrome-associated p150Glued in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities

open access: yesnpj Parkinson's Disease, 2023
Multiple missense mutations in p150Glued are linked to Perry syndrome (PS), a rare neurodegenerative disease pathologically characterized by loss of nigral dopaminergic (DAergic) neurons.
Jia Yu   +5 more
doaj   +1 more source

Artificial miRNA mediated resistance in tobacco against Jatropha leaf curl Gujarat virus by targeting RNA silencing suppressors

open access: yesScientific Reports, 2021
The leaf curl disease of Jatropha caused by geminiviruses results in heavy economic losses. In the present study, we report the identification of a new strain of a Jatropha leaf curl Gujarat virus (JLCuGV), which encodes six ORFs with each one having RNA
Prashant More   +4 more
doaj   +1 more source

Pyramiding of transcription factor, PgHSF4, and stress-responsive genes of p68, Pg47, and PsAKR1 impart multiple abiotic stress tolerance in rice (Oryza sativa L.)

open access: yesFrontiers in Plant Science, 2023
Abiotic stresses such as drought, salinity, and heat stress significantly affect rice crop growth and production. Under uncertain climatic conditions, the concurrent multiple abiotic stresses at different stages of rice production became a major ...
H. S. Sheela   +5 more
doaj   +1 more source

Breaking tolerance in transgenic mice expressing the human TSH receptor A-subunit: thyroiditis, epitope spreading and adjuvant as a 'double edged sword'. [PDF]

open access: yes, 2012
Transgenic mice with the human thyrotropin-receptor (TSHR) A-subunit targeted to the thyroid are tolerant of the transgene. In transgenics that express low A-subunit levels (Lo-expressors), regulatory T cell (Treg) depletion using anti-CD25 before ...
Aliesky, Holly A   +4 more
core   +8 more sources

PagERF16 of Populus Promotes Lateral Root Proliferation and Sensitizes to Salt Stress

open access: yesFrontiers in Plant Science, 2021
The aggravation of soil salinization limits the growth and development of plants. The AP2/ERF transcription factors (TFs) have been identified and play essential roles in plant development and stress response processes.
Shengji Wang   +5 more
doaj   +1 more source

Transgene Design [PDF]

open access: yes, 2010
Transgenics are powerful mouse models to understand the biological functions of genes. This chapter gives a short overview of the requirements and considerations in designing a transgene. In addition, potential important choices that have to be made in advance for the successful designing and generating a transgenic mouse model are discussed.
van de Sluis, Bart, Voncken, Jan Willem
openaire   +3 more sources

Current knowledge and attitudes of students towards biotechnology: A long way to go [PDF]

open access: yesIkastorratza.e-Revista de Didáctica, 2023
Thanks to technological innovations, science is rapidly evolving, and therefore, development of effective and engaging learning strategies is needed to ensure knowledge transmission. But first, we need to know what the current situation is.
Ainhoa Alberro   +2 more
doaj   +1 more source

AGE-induced neuronal cell death is enhanced in G2019S LRRK2 mutation with increased RAGE expression

open access: yesTranslational Neurodegeneration, 2018
Background Leucine-rich repeat kinase 2 (LRRK2) mutations represent the most common genetic cause of sporadic and familial Parkinson’s disease (PD). Especially, LRRK2 G2019S missense mutation has been identified as the most prevalent genetic cause in the
Hyun Jin Cho, Chengsong Xie, Huaibin Cai
doaj   +1 more source

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