Results 91 to 100 of about 855,147 (298)
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Transient Reward Approximation for Continuous-Time Markov Chains
, 2015 We are interested in the analysis of very large continuous-time Markov chains (CTMCs) with many distinct rates. Such models arise naturally in the context of reliability analysis, e.g., of computer network performability analysis, of power grids, of ...
Becker, Bernd +3 more
core +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Exploiting the Tradeoff between Program Accuracy and Soft-error Resiliency Overhead for Machine Learning Workloads [PDF]
arXiv, 2017 To protect multicores from soft-error perturbations, resiliency schemes have been developed with high coverage but high power and performance overheads. Emerging safety-critical machine learning applications are increasingly being deployed on these platforms.
arxiv
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Thermal Transient Multisource Simulation Using Cubic Spline Interpolation of Zth Functions [PDF]
Dans Proceedings of 12th International Workshop on Thermal
investigations of ICs - THERMINIC 2006, Nice : France (2006), 2007 This paper presents a very straightforward method to compute the transient thermal response to arbitrary power dissipation profiles in electronic devices with multiple heat sources. Using cubic spline interpolation of simulated or measured unit power step response curves (Zth-functions), additional errors due to model reduction can be avoided.
arxiv
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Partial Differential Equations in Applied MathematicsThe prominent novelty of current review is to exhibit the fluctuating and oscillatory convective heat transfer properties along various geometries with magnetic force, variable density, Prandtl number, buoyancy force and magnetic Prandtl number effects ...
Hossam A. Nabwey +4 more
doaj
, 2010 We present a generic API suitable for provision of highly generic storage facilities that can be tailored to produce various individually customised storage infrastructures.
Dearle, Alan +3 more
core +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source