Results 51 to 60 of about 589,822 (305)

Estimating Relevant Portion of Stability Region using Lyapunov Approach and Sum of Squares

, 2017
Traditional Lyapunov based transient stability assessment approaches focus on identifying the stability region (SR) of the equilibrium point under study.
Centeno, Virgilio A., Mishra, Chetan, Pal, Anamitra, Thorp, James S.   +3 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Robust computer-aided synthesis and optimization of linear multivariable control systems with varying plant dynamics via AUTOCON [PDF]

AUTOCON is an automated computer-aided design tool for the synthesis and optimization of linear multivariable control systems based upon user-defined control parameter optimization.
Lefkowitz, C. P., Pujara, P. K., Safonov, M. G., Tekawy, J. A.   +3 more
core   +1 more source

PENGENDALI KECEPATAN MOTOR DC DENGAN UMPAN MAJU BERBASIS MIKROKONTROLER ATMEGA 16 DENGAN KENDALI HMI VISUAL BASIC 6.0 (The Control Speeds DC with a Forward Based Microcontroler ATMega 16 with Control HMI Visual Basic 6.0) [PDF]

, 2014
Speed control device is a speed measuring instrumentation equipped with a microcontroller and a set of computers. Temperature measuring instrumentation consists of a series DC motor and speed control device.
Masita , Maya
core  

Estimation of Conservative Contaminant Travel Time through Vadose Zone Based on Transient and Steady Flow Approaches

Water, 2018
Estimation of contaminant travel time through the vadose zone is needed for assessing groundwater vulnerability to pollution, planning monitoring and remediation activities or predicting the effect of land use change or climate change on groundwater ...
A. Szymkiewicz, Anna Gumuła-Kawęcka, Dawid Potrykus, Beata Jaworska-Szulc, Małgorzata Pruszkowska-Caceres, Wioletta Gorczewska‐Langner   +5 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Techniques to Understand Computer Simulations: Markov Chain Analysis [PDF]

The aim of this paper is to assist researchers in understanding the dynamics of simulation models that have been implemented and can be run in a computer, i.e. computer models.
José Manuel Galán, Jos� Ignacio Santos, Luis R. Izquierdo, Segismundo S. Izquierdo   +3 more
core  

Havens: Explicit Reliable Memory Regions for HPC Applications

, 2016
Supporting error resilience in future exascale-class supercomputing systems is a critical challenge. Due to transistor scaling trends and increasing memory density, scientific simulations are expected to experience more interruptions caused by transient ...
Engelmann, Christian, Hukerikar, Saurabh
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source