Results 91 to 100 of about 443,050 (267)

Transient response enhancement method for DC-DC converters based on adaptive duty cycle adjustment

Ain Shams Engineering Journal
This article presents an adaptive duty cycle adjustment DC-DC converter for improving load transient response. The combination of adaptive clock control and DAC output variable reference voltage allows for rapid duty cycle saturation to further increase ...
Zhongjie Guo, Ziyi Qiu, Haoliang Wang, Ningmei Yu   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Kilonova Constraints for the LIGO/Virgo/KAGRA Neutron Star Merger Candidate S250206dm: GW-MMADS Observations

The Astrophysical Journal Letters
Gravitational-wave (GW) neutron star mergers with an associated electromagnetic counterpart constitute powerful probes of binary evolution, the production sites of heavy elements, general relativity, and the expansion of the Universe.
Lei Hu, Tomás Cabrera, Antonella Palmese, James Freeburn, Mattia Bulla, Igor Andreoni, Xander J. Hall, Brendan O’Connor, Ariel Amsellem, Clécio R. Bom, Malte Busmann, Jennifer Fabà, Julius Gassert, Sena Kalabalik, Keerthi Kunnumkai, Daniel Gruen, Luidhy Santana-Silva, André Santos, Tomás Ahumada, Jonathan Carney, Michael W. Coughlin, Xingzhuo Chen, K. E. Saavik Ford, Daniel E. Holz, Mansi M. Kasliwal, Ignacio Magaña Hernandez, Cassidy Mihalenko, Rosalba Perna, Arno Riffeser, Christoph Ries, Lena Schnappinger, Michael Schmidt, Julian Sommer, Sarah Teague, Pablo Vega, Olga Volchansky, Lifan Wang, Yajie Zhang   +37 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Study on the linear dynamic range and anti-background light interference of n-Si/n-ZnO heterojunction photodetectors enhanced by transient current

Nano Research
The self-powered photodetectors (PDs) have gained much attention due to they do not require additional external energy and can be well applied in distributed optoelectronic detection networks. However, the small built-in electric field and rich interface
Yongle Zhang, Xue Feng, Feng Yang, Yingfeng Duan, Yuwei Zhao, Tuo Chen, Peng Wang, Junmeng Guo, Zuliang Du, Gang Cheng   +9 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Research on longitudinal resolution of loop source transient electromagnetic method

Meikuang Anquan
The loop source transient electromagnetic method has been widely applied in the hydrogeological exploration of coal mines, such as demarcating impermeable layers, detecting waterlogged goaf areas, and evaluating hydro-geological parameters.
Tao XING, Zhihai JIANG, Lele MENG, Peiyu LI   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Research and application of response characteristics of mine transient electromagnetic perspective detection technology

Meitan xuebao
Aiming at the difficulty in detecting concealed geological isomers using conventional geophysical method in ultra-wide coal working face, the electromagnetic response mechanism of mine transient electromagnetic (TEM) perspective detection with opposite ...
Maofei LI, Zhihai JIANG, Shucai LIU, Xuerui TONG, Shangbin CHEN, Zhaofeng GAO, Qi DAI   +6 more
doaj   +1 more source