Results 71 to 80 of about 4,038,778 (298)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

PEARLS: 21 Transients Found in the Three-epoch NIRCam Observations in the Continuous Viewing Zone of the James Webb Space Telescope

The Astrophysical Journal
We present 21 transients from our three-epoch, four-band NIRCam observations covering 14.16 arcmin ^2 in the Spitzer IRAC Dark Field (IDF), taken by the JWST Prime Extragalactic Areas for Reionization and Lensing Science program with a time cadence of ∼6
Haojing Yan, Bangzheng Sun, Zhiyuan Ma, Lifan Wang, Christopher N. A. Willmer, Wenlei Chen, Norman A. Grogin, John F. Beacom, S. P. Willner, Seth H. Cohen, Rogier A. Windhorst, Rolf A. Jansen, Cheng Cheng, Jia-Sheng Huang, Min Yun, Hansung B. Gim, Heidi B. Hammel, Stefanie N. Milam, Anton M. Koekemoer, Lei Hu, José M. Diego, Jake Summers, Jordan C. J. D’Silva, Dan Coe, Christopher J. Conselice, Simon P. Driver, Brenda Frye, Madeline A. Marshall, Rafael Ortiz III, Nor Pirzkal, Aaron Robotham, Russell E. Ryan Jr., Rachel Honor, Rosalia O’Brien, Giovanni G. Fazio, Nathan J. Adams, Massimo Ricotti, Payaswini Saikia, Nimish P. Hathi, Brent Smith, Benne W. Holwerda, Patrick Kelly   +41 more
doaj   +1 more source

A transient-preserving audio time-stretching algorithm and a real-time realization for a commercial music product [PDF]

, 2022
The core of this work is a sub-band transient detection/preservation scheme based on the complex domain transient detection, and inspired by Robel’s work.
Altoè, Alessandro
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

CHIME/Slow Overview and Pilot Survey: A New Backend to Search for Second-duration Radio Transients with the CHIME Telescope

The Astrophysical Journal
We present an overview of CHIME/Slow, a real-time transient search backend under development to search for second-duration radio transients using the CHIME telescope, and results obtained from a pilot survey carried out using the prototype version of the
Sujay Mate, Kevin Luke, Yash Bhusare, Arvind Balasubramanian, Ziggy Pleunis, Paul Scholz, Shriharsh P. Tendulkar, Mohit Bhardwaj, Charanjot Brar, Fengqiu Adam Dong, Emmanuel Fonseca, B. M. Gaensler, Jason Hessels, Jeff Huang, Naman Jain, Ronniy C. Joseph, Victoria M. Kaspi, Afrokk Khan, Robert Main, Bradley W. Meyers, Nikola Milutinovic, Kenzie Nimmo, Kaitlyn Shin, David Spear, Ingrid Stairs, Chia Min Tan   +25 more
doaj   +1 more source

Research on borehole transient electromagnetic positioning method of azimuthal coil scanning detection

Meitan xuebao
The borehole transient electromagnetic method is used to detect the long-range water-bearing bodies around the borehole wall by using the advanced water exploration borehole in the heading roadway, which avoids the “one’s opinion in one hole” because the
Jiulong CHENG, Chenglin JIANG, Yao LI, Renxi BAI   +3 more
doaj   +1 more source

Data-driven Detection of Multimessenger Transients [PDF]

The Astrophysical Journal Letters, 2020
Abstract The primary challenge in the study of explosive astrophysical transients is their detection and characterization using multiple messengers. For this purpose, we have developed a new data-driven discovery framework, based on deep learning. We demonstrate its use for searches involving neutrinos, optical supernovae, and gamma-rays.
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Detection of persistent signals and its relation to coherent feed-forward loops [PDF]

Royal Society Open Science, 2018
Many studies have shown that cells use the temporal dynamics of signalling molecules to encode information. One particular class of temporal dynamics is persistent and transient signals, i.e. signals of long and short duration, respectively.
Chun Tung Chou
doaj   +1 more source