Results 51 to 60 of about 443,050 (267)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

PEARLS: 21 Transients Found in the Three-epoch NIRCam Observations in the Continuous Viewing Zone of the James Webb Space Telescope

The Astrophysical Journal
We present 21 transients from our three-epoch, four-band NIRCam observations covering 14.16 arcmin ^2 in the Spitzer IRAC Dark Field (IDF), taken by the JWST Prime Extragalactic Areas for Reionization and Lensing Science program with a time cadence of ∼6
Haojing Yan, Bangzheng Sun, Zhiyuan Ma, Lifan Wang, Christopher N. A. Willmer, Wenlei Chen, Norman A. Grogin, John F. Beacom, S. P. Willner, Seth H. Cohen, Rogier A. Windhorst, Rolf A. Jansen, Cheng Cheng, Jia-Sheng Huang, Min Yun, Hansung B. Gim, Heidi B. Hammel, Stefanie N. Milam, Anton M. Koekemoer, Lei Hu, José M. Diego, Jake Summers, Jordan C. J. D’Silva, Dan Coe, Christopher J. Conselice, Simon P. Driver, Brenda Frye, Madeline A. Marshall, Rafael Ortiz III, Nor Pirzkal, Aaron Robotham, Russell E. Ryan Jr., Rachel Honor, Rosalia O’Brien, Giovanni G. Fazio, Nathan J. Adams, Massimo Ricotti, Payaswini Saikia, Nimish P. Hathi, Brent Smith, Benne W. Holwerda, Patrick Kelly   +41 more
doaj   +1 more source

Data-driven Detection of Multimessenger Transients [PDF]

The Astrophysical Journal Letters, 2020
Abstract The primary challenge in the study of explosive astrophysical transients is their detection and characterization using multiple messengers. For this purpose, we have developed a new data-driven discovery framework, based on deep learning. We demonstrate its use for searches involving neutrinos, optical supernovae, and gamma-rays.
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Detection of transient fluorine atoms [PDF]

AIP Conference Proceedings, 1986
A KrF excimer laser with a fluence of 50 mJ/cm2 was used to photolyze either uranium hexafluoride or molecular fluorine, yielding a transient number density of fluorine atoms. The rise and decay of the atomic fluorine density was observed by transient absorption of a 404-cm−1 Pb-salt diode laser, which corresponds to the 2P3/2 → 2P1/2 spin-orbital ...
Loge, G.W., Nereson, N., Fry, H.A.
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Large Array Survey Telescope – Pipeline

Astronomy & Astrophysics
Context. The Large Array Survey Telescope (LAST) is a wide-field visual-band survey designed to explore the variable and transient sky with high cadence.
Konno R., Ofek E. O., Krassilchtchikov A., Shvartzvald Y., Ben-Ami S., Polishook D., Tishler C., Segre E., Garrappa S., Zimmermann E. A., Horowicz A., Chen P., Gal-Yam A., Engel M., Shani Y. M., Spitzer S. A., Fainer S., Yaron O., Blumenzweig A.   +18 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source