Results 111 to 120 of about 443,050 (267)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

CHIME/Fast Radio Burst/Pulsar Discovery of a Nearby Long-period Radio Transient with a Timing Glitch

The Astrophysical Journal Letters
We present the discovery of a 421 s long period transient using the CHIME telescope, CHIME J0630+25. The source is localized to R.A. = 06:30:38.4 $\pm 1^{\prime} $ decl.
Fengqiu Adam Dong, Tracy E Clarke, Alice Curtin, Ajay Kumar, Ryan Mckinven, Kaitlyn Shin, Ingrid Stairs, Charanjot Brar, Kevin Burdge, Shami Chatterjee, Amanda M. Cook, Emmanuel Fonseca, B. M. Gaensler, Jason W. Hessels, Victoria M. Kaspi, Mattias Lazda, Robert Main, Kiyoshi W. Masui, James W. McKee, Bradley W. Meyers, Aaron B. Pearlman, Scott M. Ransom, Paul Scholz, Kendrick M. Smith, Chia Min Tan   +24 more
doaj   +1 more source

STDweb: simple transient detection pipeline for the web

Acta Polytechnica
We present a simple web-based tool, STDWeb, for a quick-look photometry and transient detection in astronomical images. It tries to implement a self-consistent and mostly automatic data analysis workflow that would work on any image uploaded to it, allowing to perform basic interactive masking, object detection, astrometric calibration of the image ...
openaire   +4 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Identifying Transient Hosts in LSST’s Deep Drilling Fields with Galaxy Catalogs

The Astrophysical Journal
The upcoming Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST) will enable astronomers to discover rare and distant astrophysical transients.
J. G. Weston, D. R. Young, S. J. Smartt, M. Nicholl, M. J. Jarvis, I. H. Whittam   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Strategy for Identifying Vera C. Rubin Observatory Kilonova Candidates for Targeted Gravitational-wave Searches

The Astrophysical Journal
Since the observation of the binary neutron star merger GW170817 and the associated kilonova AT2017gfo, the next joint gravitational-wave/optical kilonova has been highly anticipated. Overlapping observations between the Vera C. Rubin Observatory and the
Simon Stevenson, Anais Möller, Jade Powell   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source