Results 61 to 70 of about 247,695 (263)

Transient Dynamics of Stimulated Raman Scattering in Gas-Filled Hollow-Core Photonic Crystal Fibers

Advances in Materials Science and Engineering, 2018
A theoretical and numerical investigation of transient dynamics of stimulated Raman scattering (SRS) inside gas-filled hollow-core photonic crystal fibers (HCPCFs) is reported here.
Yashar E. Monfared
doaj   +1 more source

How Does a Divided Population Respond to Change? [PDF]

PLoS ONE, 2015
Most studies on the response of socioeconomic systems to a sudden shift focus on long-term equilibria or end points. Such narrow focus forgoes many valuable insights.
Murad R Qubbaj, Rachata Muneepeerakul, Rimjhim M Aggarwal, John M Anderies   +3 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PIDGeuN: Graph Neural Network-Enabled Transient Dynamics Prediction of Networked Microgrids Through Full-Field Measurement

IEEE Access
A Physics-Informed Dynamic Graph Neural Network (PIDGeuN) is presented to accurately, efficiently and robustly predict the nonlinear transient dynamics of microgrids in the presence of disturbances.
Yin Yu, Xinyuan Jiang, Daning Huang, Yan Li, Meng Yue, Tianqiao Zhao   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Transient Dynamics of Pinning

, 2000
We study the evolution of an elastic string into the pinned state at driving forces slightly below the depinning threshold force $F_c$. We quantify the temporal evolution of the string by an {\it activity function} $A(t)$ representing the fraction of active nodes at time $t$ and find three distinct dynamic regimes.
Leaf, G. K., Obukhov, S., Scheidl, S., Vinokur, V. M.   +3 more
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Numerical Simulation of Shock and Vibration Tests for Converter Cabinet

机车电传动, 2012
According to the standard GB/T 21563 2008 ’Railway applications- Rolling stock equipment- Shock and vibration tests’, the responses of the structure under random loading were computed by the finite-element analysis software ANSYS.
丁杰, 忻力, 荣智林, 陈燕平
doaj