Results 81 to 90 of about 247,695 (263)

Projecting regional climate and cropland changes using a linked biogeophysical‐socioeconomic modeling framework: 2. Transient dynamics

Journal of Advances in Modeling Earth Systems, 2017
Understanding climate‐cropland interactions and their impact on future projections in West Africa motivated the recent development of a modeling framework that asynchronously couples four models for regional climate, crop growth, socioeconomics, and ...
Kazi Farzan Ahmed, Guiling Wang, Liangzhi You, Richard Anyah, Chuanrong Zhang, Amy Burnicki   +5 more
doaj   +1 more source

Transient Dynamics for Neural Processing

Science, 2008
A computational view of how perception and cognition can be modeled as dynamic patterns of transient activity within neural networks.
Rabinovich, Misha, Huerta, Ramon, Laurent, Gilles   +2 more
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Transient dynamics of quasinormal mode sums

Journal of High Energy Physics
Quasinormal modes of spacetimes with event horizons are typically governed by a non-normal operator. This gives rise to spectral instabilities, a topic of recent interest in the black hole pseudospectrum programme. In this work we show that non-normality
Javier Carballo, Benjamin Withers
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Unraveling Spatiotemporal Transient Dynamics at the Nanoscale via Wavelet Transform-Based Kelvin Probe Force Microscopy. [PDF]

ACS Nano, 2023
Biglarbeigi P, Morelli A, Pauly S, Yu Z, Jiang W, Sharma S, Finlay D, Kumar A, Soin N, Payam AF.   +9 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Transient synchronization stability of photovoltaics integration by singular perturbation analysis

Frontiers in Energy Research
The integration of large-scale photovoltaics (PVs) into the power grid has significantly altered the transient synchronization dynamics of traditional power systems dominated by synchronous generators (SGs) and posed great challenges to modeling and ...
Jiaqi Wu, Miao Han, Meng Zhan
doaj   +1 more source

Stellar dynamics around transient co-rotating spiral arms

EPJ Web of Conferences, 2012
Spiral density wave theory attempts to describe the spiral pattern in spiral galaxies in terms of a long-lived wave structure with a constant pattern speed in order to avoid the winding dilemma.
Cropper M., Grand R.J.J., Kawata D.
doaj   +1 more source