Results 111 to 120 of about 10,401,010 (296)

Structure–Function Relationship and Physiological Roles of Transient Receptor Potential Canonical (TRPC) 4 and 5 Channels

Cells, 2019
The study of the structure−function relationship of ion channels has been one of the most challenging goals in contemporary physiology. Revelation of the three-dimensional (3D) structure of ion channels has facilitated our understanding of many of ...
Jinsung Kim, Juyeon Ko, Chansik Hong, Insuk So   +3 more
doaj   +1 more source

Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients

, 2019
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is hallmarked by a significant reduction in natural killer (NK) cell cytotoxicity, a mechanism tightly regulated by calcium (Ca2+).
Balinas, C, Cabanas, H, Staines, D, Marshall-Gradisnik, S   +3 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

“Immuno-Transient Receptor Potential Ion Channels”: The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses

Frontiers in Immunology, 2018
Monocytes and macrophages play important roles in health and disease. They have a central role in protecting the host, as they clear pathogens and modulate other immune cell functions through the production of regulatory molecules.
Giorgio Santoni, Maria Beatrice Morelli, Maria Beatrice Morelli, Consuelo Amantini, Matteo Santoni, Massimo Nabissi, Oliviero Marinelli, Oliviero Marinelli, Angela Santoni, Angela Santoni   +9 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Bibliometric Analysis of Global Research on Transient Receptor Potential Vanilloid 1 in the Field of Pain

, 2023
Sisi Wang,1 Wen Wang,2 Xiangming Ye1 1Center for Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital,
Wang S, Wang W, Ye X
core  

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. [PDF]

, 2015
Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is ...
Martina Svensson, Osman, AM, Salomonsson, E, Oliva Martín, María José, Annette Persson, Burguillos García, Miguel Ángel, Garcia-Quintanilla, Albert, Nikenza Viceconte, Englund, Elisabet,, Schulte, Tim, Elisabet Englund, Schulte, Tim,, Albert Garcia-Quintanilla, Kavanagh, Edel, Ahmed Mohamed Osman, Santiago, M, Joseph, Bertrand, García-Quintanilla, Alberto, Amar, Lahouari, Deierborg, Tomas,, Persson, A, Venero, Jose Luis, Blomgren, Klas, Englund, E, Leffler, H, Jose Luis Venero, Boza Serrano, Antonio, Burguillos, MA, García Quintanilla, Alberto, Martiniano Santiago, Antonio Boza-Serrano, Hakon Leffler, Joseph, B, Deierborg, Tomas, Englund, Elisabet, Persson, Annette,, Amar, L, Edel Kavanagh, Kavanagh, E, Lund University., Leffler, Hakon,, Emma Salomonsson, Venero, JL, Boza Serrano, Antonio,, Santiago, Martiniano, Venero Recio, José Luis, Amar, Lahouari,, Kavanagh, Edel T., Oliva-Martín, María J., Blomgren, K, Svensson, Martina,, Miguel Angel Burguillos, Viceconte, Nikenza, Bertrand Joseph, Salomonsson, Emma,, Oliva-Martin, Maria Jose, Svensson, Martina, Tim Schulte, Maria Jose Oliva-Martin, Osman, Ahmed Mohamed, Oliva-Martin, MJ, Boza-Serrano, A, Salomonsson, Emma, Persson, Annette, Achour, A, Garcia-Quintanilla, A, Adnane Achour, Achour, Adnane, Burguillos Garcia, Miguel, Viceconte, N, Burguillos Garcia, Miguel,, Santiago Pavón, Martiniano, Schulte, T, Tomas Deierborg, Svensson, M, Venero, José L., Klas Blomgren, Lahouari Amar, Deierborg, T, Burguillos, Miguel Angel, Leffler, Hakon, Boza-Serrano, Antonio   +81 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Upregulated TRPC3 and downregulated TRPC1 channel expression during hypertension is associated with increased vascular contractility in rat

Frontiers in Physiology, 2011
Transient receptor potential C1 and C3 (TRPC1 and TRPC3) are expressed in vascular smooth muscle cells and are thought to be involved in vascular contractility.
Muzamil M Noorani, Rebecca C Noel, Sean eMarrelli, Sean eMarrelli   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source