Results 111 to 120 of about 399,869 (302)

Structure–Function Relationship and Physiological Roles of Transient Receptor Potential Canonical (TRPC) 4 and 5 Channels

Cells, 2019
The study of the structure−function relationship of ion channels has been one of the most challenging goals in contemporary physiology. Revelation of the three-dimensional (3D) structure of ion channels has facilitated our understanding of many of ...
Jinsung Kim, Juyeon Ko, Chansik Hong, Insuk So   +3 more
doaj   +1 more source

Papel dos receptores cininérgicos na neuropatia periférica induzida pelo quimioterápico paclitaxel [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduaçao em Farmacologia, Florianópolis, 2013A neuropatia periférica induzida por quimioterápicos (NPIQ) é uma das principais causas de dor ...
Costa, Robson da
core  

TRPA1

, 2014
The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation channel permeable to Ca(2+), Na(+), and K(+). TRPA1 is a promiscuous chemical nocisensor that is also involved in noxious cold and mechanical sensation.
Zygmunt, Peter,, Högestätt, Edward,, Lund University.   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

“Immuno-Transient Receptor Potential Ion Channels”: The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses

Frontiers in Immunology, 2018
Monocytes and macrophages play important roles in health and disease. They have a central role in protecting the host, as they clear pathogens and modulate other immune cell functions through the production of regulatory molecules.
Giorgio Santoni, Maria Beatrice Morelli, Maria Beatrice Morelli, Consuelo Amantini, Matteo Santoni, Massimo Nabissi, Oliviero Marinelli, Oliviero Marinelli, Angela Santoni, Angela Santoni   +9 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation

, 2010
The transient potential receptor vanilloid 1 (TRPV1) receptor is a non-selective cation channel that is chemically activated by capsaicin, the pungent component of hot peppers.
Keeble, Julie; id_orcid, Julie Keeble, Khadija Alawi, Alawi, Khadija   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Upregulated TRPC3 and downregulated TRPC1 channel expression during hypertension is associated with increased vascular contractility in rat

Frontiers in Physiology, 2011
Transient receptor potential C1 and C3 (TRPC1 and TRPC3) are expressed in vascular smooth muscle cells and are thought to be involved in vascular contractility.
Muzamil M Noorani, Rebecca C Noel, Sean eMarrelli, Sean eMarrelli   +3 more
doaj   +1 more source

Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants.

Gulf War Illness (GWI) is a chronic condition characterized by multisystem symptoms that still affect up to one-third of veterans who engaged in combat in the Gulf War three decades ago.
James N Baraniuk, Katsuhiko Muraki, Muraki, Katsuhiko, Baraniuk, James N, Sonya Marshall-Gradisnik, Natalie Eaton-Fitch, Eaton-Fitch, Natalie, Marshall-Gradisnik, Sonya, Etianne Martini Sasso, Smith, Peter, Peter Smith, Sasso, Etianne Martini   +11 more
core   +1 more source