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Brain transient receptor potential channels and stroke
Journal of Neuroscience Research, 2014Transient receptor potential (TRP) channels have been increasingly implicated in the pathological mechanisms of CNS disorders. TRP expression has been detected in neurons, astrocytes, oligodendrocytes, microglia, and ependymal cells as well as in the cerebral vascular endothelium and smooth muscle.
Eric, Zhang, Ping, Liao
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Transient Receptor Potential Channels on Sensory Nerves
2009The somatosensory effects of natural products such as capsaicin, mustard oil, and menthol have been long recognized. Over the last decade, the identification of transient receptor potential (TRP) channels in primary sensory neurons as the targets for these agents has led to an explosion of research into the roles of "thermoTRPs" TRPV1, TRPV2, TRPV3 ...
S R, Eid, D N, Cortright
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Transient Receptor Potential Channels in neuropathic pain
Current Opinion in Pharmacology, 2017Neuropathic pain caused by disease or dysfunction of the nervous system is one of the most difficult pain conditions to treat. Symptoms include a hypersensitivity to mechanical and thermal stimuli, processed by specialized nociceptors that constitute the first line of defence of the somatosensory system.
Lilian, Basso, Christophe, Altier
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Transient Receptor Potential Channels
2011Volume 696 SOFTWARE TOOLS AND ALGORITHMS FOR BIOLOGICALSYSTEMSEdited by Hamid R. Arabnia and Quoc-Nam TranVolume 697 HOT TOPICS IN INFECTION AND IMMUNITY IN CHILDREN VIIEdited by Andrew Pollard, Adam Finn, and Nigel CurtisVolume 698 BIO-FARMS FOR NUTRACEUTICALS: FUNCTIONAL FOODAND SAFETY CONTROL BY BIOSENSORSMaria Teresa Giardi, Giuseppina Rea and ...
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Transient Receptor Potential Channels and Intracellular Signaling
2007The transient receptor potential (TRP) family of ion channels is composed of more than 50 functionally versatile cation-permeant ion channels expressed in most mammalian cell types. Considerable research has been brought to bear on the members of this family, especially with regard to their possible role as store-operated calcium channels, although ...
Geoffrey E, Woodard +2 more
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Transient receptor potential channels in bladder function
Acta Physiologica, 2012AbstractThe transient receptor potential (TRP) superfamily of cationic ion channels includes proteins involved in the transduction of several physical and chemical stimuli to finely tune physiological functions. In the urinary bladder, they are highly expressed in, but not restricted to, primary afferent neurons.
Avelino, A. +6 more
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Transient receptor potential channels and vascular function
Clinical Science, 2010TRP (transient receptor potential) channels play important roles in the regulation of normal and pathological cellular function. In the vasculature, TRP channels are present both in ECs (endothelial cells) and vascular SMCs (smooth muscle cells) and contribute to vasomotor control mechanisms in most vascular beds. Vascular TRP channels are activated by
Scott, Earley, Joseph E, Brayden
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Transient receptor potential channels as drug targets
Expert Opinion on Therapeutic Targets, 2007The mammalian transient receptor potential (TRP) superfamily of ion channels consists of voltage-independent, non-selective cation channels that are expressed in excitable and non-excitable cells. The biologic roles of TRP channels are diverse and include vascular tone, thermosensation, irritant stimuli sensing and flow sensing in the kidney.
Dayne Y, Okuhara +2 more
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Transient Receptor Potential Ion Channels
Annals of Surgery, 2014This article reviews the current understanding of transient receptor potential ion channels (TRP channels) in health and disease.Transient receptor potential ion channels are a group of 27 channels that are expressed in all tissues. These channels play important roles in surgically important problems, such as chronic pain, susceptibility to infection ...
Adrian T, Billeter +3 more
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Transient Receptor Potential Channels in Vascular Mechanotransduction
American Journal of HypertensionAbstract Transmural pressure and shear stress are mechanical forces that profoundly affect the smooth muscle cells (SMCs) comprising the vascular wall and the endothelial cells (ECs) lining the lumen. Pressure and flow are detected by mechanosensors in these cells and translated into appropriate responses to regulate blood pressure and ...
Alfredo Sanchez Solano +3 more
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