Results 251 to 260 of about 11,727,590 (290)
Some of the next articles are maybe not open access.
Effects of chlorpyrifos on transient receptor potential channels
Toxicology Letters, 2022The well-known toxicity of chlorpyrifos (CPF) occurs via inhibition of cholinesterase (ChE), but in recent years the detrimental effects of low-dose CPF exposure have been attributed to an unknown non-cholinergic mechanism of action. We previously showed that CPF can alter gene expression of transient receptor potential canonical (TRPC) channels in ...
Wen, Li, Marion, Ehrich
openaire +2 more sources
Transient receptor potential channels in essential hypertension
Journal of Hypertension, 2006The role of nonselective cation channels of the transient receptor potential channel (TRPC) family in essential hypertension has not yet been investigated.We studied TRPCs in 51 patients with essential hypertension and 51 age-matched and sex-matched normotensive control subjects.
Liu, Daoyan +10 more
openaire +3 more sources
Transient receptor potential channels as therapeutic targets
Nature Reviews Drug Discovery, 2011Transient receptor potential (TRP) cation channels have been among the most aggressively pursued drug targets over the past few years. Although the initial focus of research was on TRP channels that are expressed by nociceptors, there has been an upsurge in the amount of research that implicates TRP channels in other areas of physiology and ...
Árpád Szállási +2 more
exaly +3 more sources
Transient Receptor Potential Channels and Auditory Functions
Antioxidants & Redox Signaling, 2022Significance: Transient receptor potential (TRP) channels are cation-gated channels that serve as detectors of various sensory modalities, such as pain, heat, cold, and taste. These channels are expressed in the inner ear, suggesting that they could also contribute to the perception of sound.
Vickram Ramkumar +5 more
openaire +2 more sources
Transient Receptor Potential Channels and Dermatological Disorders
Current Topics in Medicinal Chemistry, 2013Transient receptor potential (TRP) cation channels are an emerging field of research in dermatology. Beyond their classical role in skin sensory perception, TRPs are involved in various cutaneous functions that include keratinocyte differentiation, apoptosis and melanocyte pigmentation.
Rodrigo, Valdes-Rodriguez +2 more
openaire +2 more sources
Transient Receptor Potential Channels on Sensory Nerves
2009The somatosensory effects of natural products such as capsaicin, mustard oil, and menthol have been long recognized. Over the last decade, the identification of transient receptor potential (TRP) channels in primary sensory neurons as the targets for these agents has led to an explosion of research into the roles of "thermoTRPs" TRPV1, TRPV2, TRPV3 ...
S R, Eid, D N, Cortright
openaire +2 more sources
Brain transient receptor potential channels and stroke
Journal of Neuroscience Research, 2014Transient receptor potential (TRP) channels have been increasingly implicated in the pathological mechanisms of CNS disorders. TRP expression has been detected in neurons, astrocytes, oligodendrocytes, microglia, and ependymal cells as well as in the cerebral vascular endothelium and smooth muscle.
Eric, Zhang, Ping, Liao
openaire +2 more sources
Transient Receptor Potential Channels in neuropathic pain
Current Opinion in Pharmacology, 2017Neuropathic pain caused by disease or dysfunction of the nervous system is one of the most difficult pain conditions to treat. Symptoms include a hypersensitivity to mechanical and thermal stimuli, processed by specialized nociceptors that constitute the first line of defence of the somatosensory system.
Lilian, Basso, Christophe, Altier
openaire +2 more sources
Transient receptor potential channels as drug targets
Expert Opinion on Therapeutic Targets, 2007The mammalian transient receptor potential (TRP) superfamily of ion channels consists of voltage-independent, non-selective cation channels that are expressed in excitable and non-excitable cells. The biologic roles of TRP channels are diverse and include vascular tone, thermosensation, irritant stimuli sensing and flow sensing in the kidney.
Dayne Y, Okuhara +2 more
exaly +3 more sources
An overview on transient receptor potential channels superfamily
Behavioural Pharmacology, 2019The transient receptor potential (TRP) channel superfamily is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of roles in sensory signaling and are involved in plethora of animal behaviors. These channels are activated through a wide variety of mechanisms and participate in virtually every sensory ...
Merab G, Tsagareli, Ivliane, Nozadze
openaire +2 more sources