Results 251 to 260 of about 238,661 (303)

Diels‐Alder Click Chemistry as a Dynamic‐Covalent Crosslinking Method in Spheroid‐Encapsulating Hydrogels for Cartilage Engineering

Advanced Healthcare Materials, EarlyView.
This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...
Sanne M. van de Looij, Antonia G. Vasilopoulou, Lennard Spauwen, Antoinette van den Dikkenberg, Jasmijn V. Korpershoek, Mylene de Ruijter, Jos Malda, Bas G. P. van Ravensteijn, Tina Vermonden   +8 more
wiley   +1 more source

Signalling mechanisms used by the orexin-1 receptor [PDF]

Peltonen, Hanna
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Transient receptor potential channels as therapeutic targets

Nature Reviews Drug Discovery, 2011
Transient receptor potential (TRP) cation channels have been among the most aggressively pursued drug targets over the past few years. Although the initial focus of research was on TRP channels that are expressed by nociceptors, there has been an upsurge in the amount of research that implicates TRP channels in other areas of physiology and ...
Moran, Magdalene M., McAlexander, Michael Allen, Bíró, Tamás, Szállási, Árpád   +3 more
openaire   +4 more sources

Transient Receptor Potential Channels and Mechanosensation

Annual Review of Neuroscience, 2013
Transient receptor potential (TRP) channels act as sensors for a range of stimuli as diverse as light, sound, touch, pheromones, and tissue damage. Their role in mechanosensation in the animal kingdom, identified by gene ablation studies, has raised questions about whether they are directly mechanically gated, whether they act alone or in concert with ...
Niels, Eijkelkamp, Kathryn, Quick, John N, Wood   +2 more
openaire   +2 more sources

Transient Receptor Potential Channels and Auditory Functions

Antioxidants & Redox Signaling, 2022
Significance: Transient receptor potential (TRP) channels are cation-gated channels that serve as detectors of various sensory modalities, such as pain, heat, cold, and taste. These channels are expressed in the inner ear, suggesting that they could also contribute to the perception of sound.
Vickram Ramkumar, Sandeep Sheth, Asmita Dhukhwa, Raheem Al Aameri, Leonard Rybak, Debashree Mukherjea   +5 more
openaire   +2 more sources

Transient Receptor Potential Channels and Dermatological Disorders

Current Topics in Medicinal Chemistry, 2013
Transient receptor potential (TRP) cation channels are an emerging field of research in dermatology. Beyond their classical role in skin sensory perception, TRPs are involved in various cutaneous functions that include keratinocyte differentiation, apoptosis and melanocyte pigmentation.
Rodrigo, Valdes-Rodriguez, Shivani B, Kaushik, Gil, Yosipovitch   +2 more
openaire   +2 more sources

Transient receptor potential channels in essential hypertension

Journal of Hypertension, 2006
The role of nonselective cation channels of the transient receptor potential channel (TRPC) family in essential hypertension has not yet been investigated.We studied TRPCs in 51 patients with essential hypertension and 51 age-matched and sex-matched normotensive control subjects.
Liu, Daoyan, Scholze, Alexandra, Zhu, Zhiming, Krueger, Katharina, Thilo, Florian, Burkert, Antje, Streffer, Katrin, Holz, Stefan, Harteneck, Christian, Zidek, Walter, Tepel, Martin   +10 more
openaire   +3 more sources

Transient receptor potential channels and occupational exposure

Current Opinion in Allergy & Clinical Immunology, 2014
The discovery that a number of transient receptor potential (TRP) channels are expressed in a subpopulation of primary sensory neurons innervating the upper and lower airways as well as in nonneuronal cells in the airways and lungs has initiated a quest for the understanding of their role in the physiology and pathophysiology of the respiratory tract ...
Geppetti P, Patacchini R, Nassini R.
openaire   +2 more sources