Results 91 to 100 of about 6,392,109 (288)
Label-Free Detection of HeLa Cells Activity Excited by Blue LED
SensorsThis paper investigates a novel optical method that uses a high-responsivity a-Si:H photodiode for label-free detection of luminescence from HeLa cervical cancer cells excited by a blue LED. We examine the energy distribution of the energy-gap density of
Vera Gradišnik +2 more
doaj +1 more source
Bending and vibration analysis of multi-folding laminate composite plate using finite element method
Vietnam Journal of Mechanics, 2012 This paper deals with the bending and vibration analysis of multi-folding laminate composite plate using finite element method based on the first order shear deformation theory (FSDT).
Tran Ich Thinh +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Applied SciencesTransient mechanisms are increasingly applied in fields such as high-speed aircraft, super high-speed trains, and underwater robots. However, in high-speed motion, large inertial forces are inevitably generated, which can easily lead to elastic ...
Yue Bai +7 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Free vibration analysis of plates and shells by using the Superposition Method [PDF]
, 2010 This thesis is devoted to investigate the capability of the Superposition Method for obtaining the transient response of plates and the natural frequencies of thin doubly curved shallow shells.
Mochida, Yusuke
core
Understanding the influence of cation and anion migration on perovskite light-emitting diodes via transient response. [PDF]
Sci Rep, 2023 Forozi Sowmeeh P +2 more
europepmc +1 more source