Results 101 to 110 of about 6,392,109 (288)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Study on the Transient Responses of Composite Lining Tunnels Subjected to Blasting P-Waves and SV-Waves

Applied Sciences
Grounded in the principles of wave dynamics, this study employs the wave function expansion approach to mathematically describe how plane P- and SV-waves scatter around a composite tunnel lining embedded in an unbounded medium. To establish the transient
Yao Rong, Zhiyun Liu, Haibin Ding, Yang Sun, Lingxiao Guan, Zhipan Han   +5 more
doaj   +1 more source

Broadband Transient Response and Wavelength-Tunable Photoacoustics in Plasmonic Hetero-nanoparticles. [PDF]

Nano Lett, 2023
Bykov AY, Xie Y, Krasavin AV, Zayats AV.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Space charges and negative capacitance effect in organic light-emitting diodes by transient current response analysis

, 2017
Space charge capacitance and the physical mechanism of negative capacitance in organic light-emitting diodes (OLEDs) by transient current response analysis are investigated for the first time.
Yang Zhang, Yiyang Li, Yiping Zeng, Min Guan, Xingfang Liu, Litao Niu   +5 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Enhanced Low‐Voltage Ride‐Through Capability of DFIG by Explicit Model Predict Control Based Decoupled Virtual Impedance

IET Renewable Power Generation
The power grid requires doubly‐fed induction generators (DFIGs) to effectively suppress rotor currents and provide reactive power support during low voltage ride‐through (LVRT) events.
Jia Luo, Haoran Zhao, Peng Wang
doaj   +1 more source

A review on the mechanism of high repetition rate pulse interference on the RF front-end of GNSS receivers

Frontiers in Physics
With the rapid advancement of pulse technology, given the extraordinarily high repetition frequency of high-repetition pulse interference, with pulse widths typically ranging from a few nanoseconds to several hundred nanoseconds, it possesses ultra ...
Yili Song, Yili Song, Huilin Wang, Wenxiang Liu, Wenxiang Liu, Wei Xiao, Wei Xiao, XiaoZhou Ye, XiaoZhou Ye, Guangfu Sun, Guangfu Sun   +10 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Transient Response of Miniature Piezoresistive Pressure Sensor Dedicated to Blast Wave Monitoring. [PDF]

Sensors (Basel), 2022
Sanchez K, Achour B, Coustou A, Lecestre A, Charlot S, Lavayssière M, Lefrançois A, Aubert H, Pons P.   +8 more
europepmc   +1 more source