Results 101 to 110 of about 854,868 (315)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Study of photocapacitor transient response of MAPbI3 perovskite-based solar cell devices

Journal of Applied Science and Engineering
Perovskite material ( MAPbI3 ) solar cells were used because of their capability to respond to light. The transient response characteristics of MAPbI3 perovskite-based solar cell devices with and without SnO2 layer were investigated in this paper.
Erry Dwi Kurniawan, Reni Dwi Putri, Widhya Budiawan, Shobih, Iqbal Syamsu, Irzaman Husein   +5 more
doaj   +1 more source

Dynamic analysis using finite element method for a nonlinear spring-supported disk: Technique to reduce second-order distortion due to diaphragm shape

Mechanical Engineering Journal, 2017
This research aims to reduce the second-order distortion due to diaphragm vibration. The quadratic term of the restoring force of nonlinear springs varies in the pulling and compression directions.
Mitsuharu WATANABE, Takao YAMAGUCHI, Manabu SASAJIMA, Tatsushi SASANUMA, Yoshio KOIKE   +4 more
doaj   +1 more source

Transients and multiperiodic responses: a hierarchy of material bits

New Journal of Physics
Abstract When cyclically driven, certain disordered materials exhibit transient and multiperiodic responses that are difficult to reproduce in synthetic materials. Here, we show that elementary multiperiodic elements with period T  = 2 — togglerons—can serve as building ...
Colin M Meulblok, Martin van Hecke
openaire   +3 more sources

Distinguishing cells by their first-order transient motion response under an optically induced dielectrophoretic force field

, 2013
This letter reports our characterization of the transient motion of cells under an optically induced dielectrophoresis (ODEP) force field. Different types of human cells repeatably undergo a first-order transient motion response when subjected to a ...
Liang WF(梁文峰), Zhang, Guanglie, Mai, John D., Zhao, Yuliang, Liu LQ(刘连庆), Li WJ(李文荣), Lee, Gwo-Bin   +6 more
core  

Transient simulation of complex electronic circuits and systems operating at ultra high frequencies [PDF]

, 2005
The electronics industry worldwide faces increasingly difficult challenges in a bid to produce ultra-fast, reliable and inexpensive electronic devices. Electronic manufacturers rely on the Electronic Design Automation (EDA) industry to produce consistent
Dautbegovic, Emira
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Fuzzy Logic-Based Adaptive Droop Control Designed with Feasible Range of Droop Coefficients for Enhanced Power Delivery in Microgrids

Engineering Proceedings
Power electronic converter-based microgrids generally suffer from poor power delivery/handling capability during sudden load changes, especially during islanded operations. This is due to the lack of transient energy support to compensate for sudden load
Mandarapu Srikanth, Yellapragada Venkata Pavan Kumar, Sivakavi Naga Venkata Bramareswara Rao   +2 more
doaj   +1 more source