Results 121 to 130 of about 854,868 (315)
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Applied SciencesTransient mechanisms are increasingly applied in fields such as high-speed aircraft, super high-speed trains, and underwater robots. However, in high-speed motion, large inertial forces are inevitably generated, which can easily lead to elastic ...
Yue Bai +7 more
doaj +1 more source
Improved Transient Network Model for Wicked Heat Pipes [PDF]
, 2006 An existing transient network model for wicked heat pipes was extended to incorporate the effects of axial heat transfer along the wall and wick, heat transfer in the surrounding media, and non-condensable gases in the vapour region.
Saad, Sameh
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Understanding the influence of cation and anion migration on perovskite light-emitting diodes via transient response. [PDF]
Sci Rep, 2023 Forozi Sowmeeh P +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Broadband Transient Response and Wavelength-Tunable Photoacoustics in Plasmonic Hetero-nanoparticles. [PDF]
Nano Lett, 2023 Bykov AY, Xie Y, Krasavin AV, Zayats AV.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Transient Response of a spiral fin with its base subjected to a variation of fluid temperatures
, 2015 The problem of transient response of a spiral fin, with its end insulated, is analyzed with the base end subjected to a variation of fluid temperature. The method of Laplace transforms and with a technique derived by the Keller and Keller, of which has ...
Wang, J.S.; Chung, C.W.; Shieh, C.S.; Luo, W.J.; Chen, Chun-Nan +1 more
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